Identification of loci associated with schizophrenia by genome-wide association and follow-up

O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Norton, Nadine ORCID: https://orcid.org/0000-0002-3848-4288, Williams, Hywel John ORCID: https://orcid.org/0000-0001-7758-0312, Peirce, Timothy Rowan, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Nikolov, Ivan, Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Carroll, Liam Stuart, Georgieva, Lyudmila, Dwyer, Sarah Lynne, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Marchini, Jonathan L, Spencer, Chris C A, Howie, Bryan, Leung, Hin-Tak, Hartmann, Annette M, Möller, Hans-Jürgen, Morris, Derek W, Shi, YongYong, Feng, GuoYin, Hoffmann, Per, Propping, Peter, Vasilescu, Catalina, Maier, Wolfgang, Rietschel, Marcella, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Schumacher, Johannes, Quinn, Emma M, Schulze, Thomas G, Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Giegling, Ina, Iwata, Nakao, Ikeda, Masashi, Darvasi, Ariel, Shifman, Sagiv, He, Lin, Duan, Jubao, Sanders, Alan R, Levinson, Douglas F, Gejman, Pablo V, Gejman, Pablo V, Sanders, Alan R, Duan, Jubao, Levinson, Douglas F, Buccola, Nancy G, Mowry, Bryan J, Freedman, Robert, Amin, Farooq, Black, Donald W, Silverman, Jeremy M, Byerley, William F, Cloninger, C Robert, Cichon, Sven, Nöthen, Markus M, Gill, Michael, Corvin, Aiden, Rujescu, Dan, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40 (9) , pp. 1053-1055. 10.1038/ng.201

Full text not available from this repository.

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).

Item Type:	Article
Status:	Published
Schools:	Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Last Modified:	07 Dec 2022 07:28
URI:	https://orca.cardiff.ac.uk/id/eprint/29847

Citation Data

Cited 907 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item