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A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies

Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Kelly, Marc A., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Davies, Philip Rosser ORCID: https://orcid.org/0000-0003-4394-766X and Allender, Christopher John 2012. A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies. Tetrahedron Letters 53 (29) , pp. 3727-3730. 10.1016/j.tetlet.2012.04.116

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Abstract

A straightforward method of creating a bifunctional support possessing pre-defined ratios of amine and chloromethyl groups based upon a controlled conversion of standard Merrifield resin is presented. It avoids the extensive optimisation of reactant concentrations and reaction conditions required by existing methods. Furthermore, it avoids increases in the spacer/linker length that lead to detrimental reductions in the rigidity of the grafted layer. The method will allow for efficient, predictable and reproducible co-immobilisation of molecular species.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Pharmacy
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Merrifield resin; Bifunctional support; Aminomethyl polystyrene; Co-immobilisation; Staudinger
Publisher: Elsevier
ISSN: 0040-4039
Last Modified: 20 Oct 2022 09:05
URI: https://orca.cardiff.ac.uk/id/eprint/30600

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