A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies

Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Kelly, Marc A., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Davies, Philip Rosser ORCID: https://orcid.org/0000-0003-4394-766X and Allender, Christopher John 2012. A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies. Tetrahedron Letters 53 (29) , pp. 3727-3730. 10.1016/j.tetlet.2012.04.116

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Abstract

A straightforward method of creating a bifunctional support possessing pre-defined ratios of amine and chloromethyl groups based upon a controlled conversion of standard Merrifield resin is presented. It avoids the extensive optimisation of reactant concentrations and reaction conditions required by existing methods. Furthermore, it avoids increases in the spacer/linker length that lead to detrimental reductions in the rigidity of the grafted layer. The method will allow for efficient, predictable and reproducible co-immobilisation of molecular species.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry Schools > Pharmacy Research Institutes & Centres > Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Merrifield resin; Bifunctional support; Aminomethyl polystyrene; Co-immobilisation; Staudinger
Publisher:	Elsevier
ISSN:	0040-4039
Last Modified:	20 Oct 2022 09:05
URI:	https://orca.cardiff.ac.uk/id/eprint/30600

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