Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Kelly, Marc A., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Davies, Philip Rosser ORCID: https://orcid.org/0000-0003-4394-766X and Allender, Christopher John 2012. A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies. Tetrahedron Letters 53 (29) , pp. 3727-3730. 10.1016/j.tetlet.2012.04.116 |
Official URL: http://dx.doi.org/10.1016/j.tetlet.2012.04.116
Abstract
A straightforward method of creating a bifunctional support possessing pre-defined ratios of amine and chloromethyl groups based upon a controlled conversion of standard Merrifield resin is presented. It avoids the extensive optimisation of reactant concentrations and reaction conditions required by existing methods. Furthermore, it avoids increases in the spacer/linker length that lead to detrimental reductions in the rigidity of the grafted layer. The method will allow for efficient, predictable and reproducible co-immobilisation of molecular species.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Pharmacy Cardiff Catalysis Institute (CCI) |
Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
Uncontrolled Keywords: | Merrifield resin; Bifunctional support; Aminomethyl polystyrene; Co-immobilisation; Staudinger |
Publisher: | Elsevier |
ISSN: | 0040-4039 |
Last Modified: | 20 Oct 2022 09:05 |
URI: | https://orca.cardiff.ac.uk/id/eprint/30600 |
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