Browse by Current Cardiff authors

Abdulkarim, Muthanna, Neto, Cátia, Laffleur, Flavia, Ramos-Pérez, Victor, Bernkop-Schnürch, Andreas, Gómez Borros, Salvador and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2025. Novel zwitterionic densely charged neutral sulfobetaine polymeric micelles for oral delivery of therapeutic peptides: a proof-of-concept study. RSC Pharmaceutics 10.1039/d4pm00202d

Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Cullen, Jason K., Boyle, Glen M., De Ridder, Tom, Yap, Pei-Yi, Xue, Wenya, Pierce, Carly J., Pritchard, Manon F., Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Abdulkarim, Muthanna, Adams, Jennifer Y. M., Stokniene, Joana, Francis, Lewis W., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Johns, Jenny, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Jones, Adam V., Parsons, Peter G., Reddell, Paul and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2022. Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine 14 (662) 10.1126/scitranslmed.abn3758

Alghamdi, Majed, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604 2021. Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies. Biomaterials Science 9 (18) , pp. 6037-6051. 10.1039/D1BM00896J

Moriconi, Chiara ORCID: https://orcid.org/0000-0001-7942-2166, Civita, Prospero ORCID: https://orcid.org/0000-0002-8313-1094, Neto, Catia, Pilkington, Geoffrey J. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2021. Caveolin-1, a key mediator across multiple pathways in glioblastoma and an independent negative biomarker of patient survival. Frontiers in Oncology 11 , 701933. 10.3389/fonc.2021.701933

Biosca, Arnau, Cabanach, Pol, Abdulkarim, Muthanna ORCID: https://orcid.org/0000-0001-5753-7261, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Gómez-Canela, Cristian, Ramírez, Miriam, Bouzón-Arnáiz, Inés, Avalos-Padilla, Yunuen, Borros, Salvador and Fernàndez-Busquets, Xavier 2021. Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment. Journal of Controlled Release 331 , pp. 364-375. 10.1016/j.jconrel.2021.01.028

Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Abdulkarim, Muthanna, Stokniene, Joana, Yang, Qui E., Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2021. Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes 7 , 13. 10.1038/s41522-020-00172-6

Civita, Prospero, Valerio, Ortenzi, Naccarato, Antonio Giuseppe, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Pilkington, Geoffrey J. 2020. Satellitosis, a crosstalk between neurons, vascular structures and neoplastic cells in brain tumours; early manifestation of invasive behaviour. Cancers 12 (12) , 3720. 10.3390/cancers12123720

El-Betany, Alaa M. M., Behiry, Enas M., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Harding, Keith G. 2020. Humidified warmed CO2 treatment therapy strategies can save lives with mitigation and suppression of SARS-CoV-2 infection: an evidence review. Frontiers in Medicine 7 , 594295. 10.3389/fmed.2020.594295

Alghamdi, Majed, Chierchini, Filippo, Eigel, Dimitri, Taplan, Christian, Miles, Thomas, Pette, Dagmar, Welzel, Petra B., Werner, Carsten, Wang, Wenxin, Neto, Catia, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604 2020. Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme. Nanoscale Advances 2 (10) , pp. 4498-4509. 10.1039/D0NA00471E

Schirmer, Lucas, Hoornaert, Chloé, Le Blon, Debbie, Eigel, Dimitri, Neto, Catia, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Welzel, Petra B., Rosser, Anne E. ORCID: https://orcid.org/0000-0002-4716-4753, Werner, Carsten, Ponsaerts, Peter and Newland, Ben 2020. Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain. Biomaterials Science 8 (18) , pp. 4997-5004. 10.1039/D0BM01249A

Brooks, Owain, Mikhail, Ashraf, Brown, Chris, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Jenkins, Justine ORCID: https://orcid.org/0000-0003-2954-6237 and Boyle, Kaitlin 2020. Sodium zirconium cyclosilicate for the treatment of persistent hyperkalaemia in prevalent haemodialysis patients: experience from clinical practice. Nephrology Dialysis Transplantation 35 (S3) , P1299. 10.1093/ndt/gfaa142.P1299

Brooks, Owain, Mikhail, Ashraf, Brown, Chris, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Jenkins, Justine ORCID: https://orcid.org/0000-0003-2954-6237 and Boyle, Kaitlin 2020. Sodium zirconium cyclosilicate to prevent hyperkalaemia if haemodialysis is postponed due to vascular access complications: experience from clinical practice. Nephrology Dialysis Transplantation 35 (S3) , P0324. 10.1093/ndt/gfaa142.P0324

El-Betany, Alaa M.M. ORCID: https://orcid.org/0000-0002-5990-1001, Kamoun, Elbadawy A., James, Craig ORCID: https://orcid.org/0000-0002-0569-182X, Jangher, Abdulhakim, Aljayyoussi, Ghaith, Griffiths, Peter, McKeown, Neil B. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2020. Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences. International Journal of Pharmaceutics 579 , 119187. 10.1016/j.ijpharm.2020.119187

Leite, Diana M., Zvar Baskovic, Barbara, Civita, Prospero, Neto, Catia, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Pilkington, Geoffrey J. 2020. A human co-culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics. The FASEB Journal 34 (1) , pp. 1710-1727. 10.1096/fj.201901858RR

Matías, Jose, Brotons, Ana, Cenoz, Santiago, Pérez, Isidoro, Abdulkarim, Muthanna, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Irache, Juan M. and Gamazo, Carlos 2019. Oral immunogenicity in mice and sows of enterotoxigenic escherichia coli outer-membrane vesicles incorporated into zein-based nanoparticles. Vaccines 8 (1) , 11. 10.3390/vaccines8010011

Inchaurraga, Laura, Martínez-López, Ana L., Abdulkarim, Muthanna ORCID: https://orcid.org/0000-0001-5753-7261, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Quincoces, Gemma, Peñuelas, Ivan, Martin-Arbella, Nekane, Irache, Juan M. and Abdulkarim, Muthanna 2019. Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate. International Journal of Pharmaceutics: X 1 , 100006. 10.1016/j.ijpx.2019.100006

Brotons-Canto, Ana, Gamazo, Carlos, Martín-Arbella, Nekane, Abdulkarim, Muthanna, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Quincoces, Gemma, Peñuelas, Ivan and Irache, Juan M. 2019. Mannosylated nanoparticles for oral immunotherapy in a murine model of peanut allergy. Journal of Pharmaceutical Sciences 108 (7) , pp. 2421-2429. 10.1016/j.xphs.2019.02.022

Abdulkarim, Muthanna ORCID: https://orcid.org/0000-0001-5753-7261, Sharma, Peeyush Kumar and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2019. Self-emulsifying drug delivery system: mucus permeation and innovative quantification technologies. Advanced Drug Delivery Reviews 142 , pp. 62-74. 10.1016/j.addr.2019.04.001

Bailey, Damian Miles, Stacey, Benjamin S. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2018. A systematic review and meta-analysis reveals altered drug pharmacokinetics in humans during acute exposure to terrestrial high altitude- clinical justification for dose adjustment? High Altitude Medicine and Biology 19 (2) , pp. 141-148. 10.1089/ham.2017.0121

Menzel, Claudia, Holzeisen, Thomas, Laffleur, Flavia, Zaichik, Sergey, Abdulkarim, Muthanna, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Bernkop-Schnürch, Andreas 2018. In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide. Journal of Controlled Release 277 , pp. 165-172. 10.1016/j.jconrel.2018.03.018

Brotons-Canto, Ana, Gamazo, Carlos, Martín-Arbella, Nekane, Abdulkarim, Muthanna, Matías, Jose, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Irache, Juan M. 2018. Evaluation of nanoparticles as oral vehicles for immunotherapy against experimental peanut allergy. International Journal of Biological Macromolecules 110 , pp. 328-335. 10.1016/j.ijbiomac.2017.09.109

Bonengel, Sonja, Jelkmann, Max, Abdulkarim, Muthanna ORCID: https://orcid.org/0000-0001-5753-7261, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Reinstadler, Vera, Oberacher, Herbert, Prüfert, Felix and Bernkop-Schnürch, Andreas 2018. Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs. Journal of Controlled Release 273 , pp. 21-29. 10.1016/j.jconrel.2018.01.012

Moriconi, Chiara ORCID: https://orcid.org/0000-0001-7942-2166, Palmieri, Valentina, Tornillo, Giusy, Fillmore, Helen, Pilkington, Geoffrey J. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2018. Caveolin-1, a driver of invasive phenotype in in-vitro 3D-spheroid assays comprised of high grade GBM cells association with an AKT-inhibited phenotype. Neuro-Oncology 20 (S1) , i13-i13. 10.1093/neuonc/nox238.058

Morris, Christopher J., Aljayyoussi, Ghaith, Mansour, Omar, Griffiths, Peter and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2017. Endocytic uptake, transport and macromolecular interactions of anionic PAMAM dendrimers within lung tissue. Pharmaceutical Research 34 (12) , pp. 2517-2531. 10.1007/s11095-017-2190-7

Price, Daniel F., Luscombe, Chris N., Eddershaw, Peter J., Edwards, Chris D. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2017. The differential absorption of a series of P-glycoprotein substrates in isolated perfused lungs from Mdr1a/1b genetic knockout mice can be attributed to distinct physico-chemical properties: an insight into predicting transporter-mediated, pulmonary specific disposition. Pharmaceutical Research 34 (12) , pp. 2498-2516. 10.1007/s11095-017-2220-5

Moriconi, Chiara ORCID: https://orcid.org/0000-0001-7942-2166, Palmieri, Valentina, di Santo, Riccardo, Tornillo, Giusy, Papi, Massimiliano, Pilkington, Geoff, De Spirito, Marco and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2017. INSIDIA: a FIJI macro delivering high-throughput and high-content spheroid invasion analysis. Biotechnology Journal 12 (10) , 1700140. 10.1002/biot.201700140

Ehrhardt, Carsten, Bäckman, Per, Couet, William, Edwards, Chris, Forbes, Ben, Fridén, Markus, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Hosoya, Ken-Ichi, Kato, Yukio, Nakanishi, Takeo, Takano, Mikihisa, Terasaki, Tetsuya and Yumoto, Ryoko 2017. Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs. Journal of Pharmaceutical Sciences 106 (9) , pp. 2234-2244. 10.1016/j.xphs.2017.04.011

Paul, Graham, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Somers, Graham I 2017. Effect of conditioning on rat lung function measurements and implications for exposure and dose estimation of inhaled drugs. Inhalation

Moriconi, Chiara ORCID: https://orcid.org/0000-0001-7942-2166, Palmieri, Valentina, Tornillo, Giusy, Fillmore, Helen, Pilkington, Geoff and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2017. Caveolin-1 implicated as a pro-invasive gene in high-grade glioma cell models: implementation of a 3d spheroid matrix invasion assay. Neuro-Oncology 19 (S1) , i21-i22. 10.1093/neuonc/now293.080

Ulaeto, David O., Morris, Christopher J., Fox, Marc A., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484 2016. Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets. Antimicrobial Agents and Chemotherapy , AAC.02146-15. 10.1128/AAC.02146-15

Williams, Nicholas A., Barnard, Luke, Allender, Chris J., Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Harrah, Tim, Raja, Aditya and Joshi, Hrishi B. 2016. Evidence of nonuniformity in urothelium barrier function between the upper urinary tract and bladder. Journal of Urology 195 (3) , pp. 763-770. 10.1016/j.juro.2015.10.066

Rohrer, Julia, Partenhauser, Alexandra, Hauptstein, Sabine, Gallati, Caroline, Matuszczak, Barbara, Abdulkarim, Muthanna, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Bernkop-Schnürch, Andreas 2016. Mucus permeating thiolated self-emulsifying drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 98 , pp. 90-97. 10.1016/j.ejpb.2015.11.004

Gustavsson, Lena, Bosquillon, Cynthia, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Hegelund-Myrbäck, Tove, Nakanishi, Takeo, Price, Dan, Tamai, Ikumi and Zhou, Xiao-Hong 2016. Chapter 6. Drug transporters in the lung: expression and potential impact on pulmonary drug disposition. Nicholls, Glynis and Youdim, Kuresh, eds. Drug Transporters : Volume 1: Role and Importance in ADME and Drug Development, Vol. 1. Royal Society of Chemistry, p. 184.

Aljayyoussi, Gaith, Price, Daniel, Kreitmeyr, Katharine, Keogh, John, Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Morris, Christopher J. 2015. Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters. International Journal of Pharmaceutics 496 (2) , pp. 834-841. 10.1016/j.ijpharm.2015.10.036

Albaldawi, Muthanna, Agulló, Nuria, Cattoz, Beatrice, Griffith, Peter, Bernkop-Schnürch, Andreas, Borros, Salvador Gómez and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2015. Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles. European Journal of Pharmaceutics and Biopharmaceutics 97 (Part A) , pp. 230-238. 10.1016/j.ejpb.2015.01.023

Grießinger, Julia, Dünnhaupt, Sarah, Cattoz, Beatrice, Griffiths, Peter, Oh, Sejin, Gómez, Salvador Borrós i, Wilcox, Matthew, Pearson, Jeffrey, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Abdulkarim, Muthanna, Pereira de Sousa, Irene and Bernkop-Schnürch, Andreas 2015. Methods to determine the interactions of micro- and nanoparticles with mucus. European Journal of Pharmaceutics and Biopharmaceutics 96 , pp. 464-476. 10.1016/j.ejpb.2015.01.005

Campbell, Lee, Jasani, Bharat, Griffiths, David F. R. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2015. Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. American Journal of Cancer Research 5 (9) , pp. 2838-2848.

Williams, Nicholas, Lee, Kay M., Allender, Christopher John, Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Harrah, Tim, Raja, Aditya and Joshi, Hrishi B. 2015. Investigating detrusor muscle concentrations of oxybutynin after intravesical delivery in an Ex Vivo porcine model. Journal of Pharmaceutical Sciences 104 (7) , pp. 2233-2240. 10.1002/jps.24471

Williams, Nicholas, Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Aljayyoussi, Ghaith, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Allender, Christopher John, Li, Jamie, Harrah, Tim, Raja, Aditya and Joshi, Hrishi B. 2014. An ex Vivo investigation into the transurothelial permeability and bladder wall distribution of the nonsteroidal anti-inflammatory Ketorolac. Molecular Pharmaceutics 11 (3) , pp. 673-682. 10.1021/mp400274z

Aljayyoussi, Ghaith, Price, Daniel F., Francombe, Danielle, Taylor, Glyn, Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Morris, Christopher John, Edwards, Chris, Eddershaw, Peter and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2013. Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout. Journal of Pharmaceutical Sciences 102 (9) , pp. 3382-3394. 10.1002/jps.23587

Matthews, Ian Price, Gregory, Clive James ORCID: https://orcid.org/0000-0003-4876-3982, Aljayyoussi, Ghaith, Morris, Christopher John, McDonald, Iain ORCID: https://orcid.org/0000-0001-9066-7244, Hoogendoorn, Bastiaan ORCID: https://orcid.org/0000-0001-9753-169X and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35 (3) , pp. 461-464. 10.1016/j.etap.2013.02.002

Aljayyoussi, Ghaith and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2013. A novel cost-effective approach for the efficient radiolabeling of dendritic macromolecules with a β-emitting radiotracer. Tetrahedron Letters 54 (9) , pp. 1045-1048. 10.1016/j.tetlet.2012.11.088

Campbell, Lee, Aljayyoussi, Ghaith, Gutteridge, Robert, Gumbleton, Nigel, Griffiths, Rosie, Gumbleton, Simon, Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Griffiths, David Francis Rees and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2013. Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease. Journal of Translational Medicine 11 (1) , 255. 10.1186/1479-5876-11-255

Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Aljayyoussi, Ghaith and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2012. Peptide sequences mediating tropism to intact blood-brain barrier: An in vivo biodistribution study using phage display. Peptides 38 (1) , pp. 172-180. 10.1016/j.peptides.2012.06.019

Yildiz, Ayca, John, Elinor, Özsoy, Yildiz, Araman, Ahmet, Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924, Broadley, Kenneth John ORCID: https://orcid.org/0000-0002-3339-2050 and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2012. Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation. Journal of Controlled Release 162 (2) , pp. 456-463. 10.1016/j.jconrel.2012.07.008

Morris, Christopher John, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Fox, Marc A., Ulaeto, David, Clark, Graeme C. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2012. Pegylation of antimicrobial peptides maintains the active peptide conformation, model membrane interactions, and antimicrobial activity while improving lung tissue biocompatibility following airway delivery. Antimicrobial Agents and Chemotherapy 56 (6) , pp. 3298-3308. 10.1128/AAC.06335-11

Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832, Kelly, Marc A., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Davies, Philip Rosser ORCID: https://orcid.org/0000-0003-4394-766X and Allender, Christopher John 2012. A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies. Tetrahedron Letters 53 (29) , pp. 3727-3730. 10.1016/j.tetlet.2012.04.116

Morris, Christopher John, Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Griffiths, Peter Charles, McKeown, Neil B. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2011. Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide. Journal of Controlled Release 151 (1) , pp. 83-94. 10.1016/j.jconrel.2010.12.003

Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Aljayyoussi, Ghaith, Crandon-Lewis, Adam Michael, Francombe, Danielle, Kreitmeyr, Katharina, Morris, Chris J. and Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204 2011. Spatial expression and functionality of drug transporters in the intact lung: objectives for further research. Advanced Drug Delivery Reviews 63 (1-2) , pp. 110-118. 10.1016/j.addr.2010.09.008

Forbes, Ben, Asgharian, Bahman, Dailey, Lea Ann, Ferguson, Douglas, Gerde, Per, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Gustavsson, Lena, Hardy, Colin, Hassall, David, Jones, Rhys, Lock, Ruth, Maas, Janet, McGovern, Tim, Pitcairn, Gary R., Somers, Graham and Wolff, Ron K. 2011. Challenges in inhaled product development and opportunities for open innovation. Advanced Drug Delivery Reviews 63 (1-2) , pp. 69-87. 10.1016/j.addr.2010.11.004

Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2010. Cellular delivery of therapeutic macromolecules (CDTM) international Symposium 2010: lessons and progress from inter-disciplinary science. Drug Discovery Today 15 (23-24) , pp. 1079-180. 10.1016/j.drudis.2010.10.010

Thomas, Nicholas B. P., Hutcheson, Iain Robert, Campbell, Lee, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Taylor, Kathryn Mary ORCID: https://orcid.org/0000-0002-9576-9490, Nicholson, Robert Ian and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2010. Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Research and Treatment 119 (3) , pp. 575-591. 10.1007/s10549-009-0355-8

Griffiths, Peter Charles, Occhipinti, Paolo, Morris, Christopher John, Heenan, Richard K., King, Stephen Michael and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2010. PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin. Biomacromolecules 11 (1) , pp. 120-125. 10.1021/bm9009667

Patton, John S., Brain, Joseph D., Davies, Lee A., Fiegel, Jennifer, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Kim, Kwang-Jin, Sakagami, Masahiro, Vanbever, Rita and Ehrhardt, Carsten 2010. The particle has landed? characterizing the fate of inhaled pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23 (S2) , S71-S87. 10.1089/jamp.2010.0836

Barar, Jaleh, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Asadi, M. and Omidi, Y. 2010. Barrier functionality and transport machineries of human ECV304 cells. Medical Science Monitor 16 (1) , BR52-BR60.

Aljayyoussi, Ghaith, Ford, William Richard ORCID: https://orcid.org/0000-0002-8792-6169, McKeown, Neil B. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2010. Differential transport of anionic PAMAM dendrimers across in vitro biological barriers [Abstract]. Drug Discovery Today 15 (23-24) , p. 1114. 10.1016/j.drudis.2010.09.440

Campbell, L., Nuttall, R., Griffiths, David Francis Rees and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2009. Activated Extracellular Signal-Regulated Kinase Is an Independent Prognostic Factor in Clinically Confined Renal Cell Carcinoma. Cancer 115 (15) , pp. 3457-3467. 10.1002/cncr.24389

Endter, S., Francombe, D., Ehrhardt, C. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2009. RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models. Journal of Pharmacy and Pharmacology 61 (5) , pp. 583-591. 10.1211/jpp/61.05.0006

Campbell, Lee, Jasani, Bharat, Edwards, K., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Griffiths, David Francis Rees 2008. Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma. British Journal of Cancer 98 (5) , pp. 931-940. 10.1038/sj.bjc.6604243

Campbell, Lee, Jasani, Bharat, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Edwards, K. and Griffiths, D. F. 2008. Expression of 4EBP1 is an influential prognostic covariate in renal cell carcinoma [Abstract]. Modern Pathology 21 (1s) , 150A. 10.1038/sj.modpathol.3801035

Omidi, Y., Barar, J., Ahmadian, S., Heidari, H. R. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2008. Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells. Cell Biochemistry and Function 26 (3) , pp. 381-391. 10.1002/cbf.1455

Smith, Matthew W., Smith, Jonathan W., Harris, Charlotte, Allender, Christopher John, Brancale, Andrea and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2007. Phage display identification of functional binding peptides against 4-acetamidophenol (Paracetamol): An exemplified approach to target low molecular weight organic molecules. Biochemical and Biophysical Research Communications 358 (1) , pp. 285-291. 10.1016/j.bbrc.2007.04.122

Collins, Elizabeth, Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924, Williams, Julie L. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2007. Nuclear localisation and pDNA condensation in non-viral gene delivery. The Journal of Gene Medicine 9 (4) , pp. 265-274. 10.1002/jgm.1015

Barar, Jaleh, Campbell, Lee., Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Thomas, Nicholas Paul, Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Morris, Christopher John and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2007. Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures. Biochemical and Biophysical Research Communications 359 (2) , pp. 360-366. 10.1016/j.bbrc.2007.05.106

Endter, S., Becker, U., Daum, N., Huwer, H., Lehr, C. M., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Ehrhardt, C. 2007. P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers. Cell and Tissue Research 328 (1) , pp. 77-84. 10.1007/s00441-006-0346-6

Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204, Omidi, Y. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2007. Primary porcine brain microvascular endothelial cells: Biochemical and functional characterisation as a model for drug transport and targeting. Journal of Drug Targeting 15 (4) , pp. 253-268. 10.1080/10611860701288539

Sakagami, Masahiro, Omidi, Yadollah ORCID: https://orcid.org/0000-0003-0067-2475, Campbell, Lee, Kandalaft, Lana E., Morris, Christopher John, Barar, Jaleh and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2006. Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Pharmaceutical research 23 (2) , pp. 270-279. 10.1007/s11095-005-9226-0

Smith, Mathew W. ORCID: https://orcid.org/0000-0002-5697-0204 and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2006. Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies. Journal of Drug Targeting 14 (4) , pp. 191-214. 10.1080/10611860600650086

Abulrob, A. N., Suller, M. T. E., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Simons, Claire ORCID: https://orcid.org/0000-0002-9487-1100 and Russell, A. D. 2004. Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains. Phytochemistry 65 (22) , pp. 3021-3027.

Von Ruhland, Christopher J., Campbell, Lee, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Jasani, Bharat and Newman, Geoffrey R. 2004. Immunolocalization of caveolin-1 in rat and human mesothelium. Journal of Histochemistry & Cytochemistry 52 (11) , pp. 1415-1425. 10.1369/jhc.4A6334.2004

Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Kandalaft, L, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Siccardi, D 2003. Stereoselective and concentration-dependent polarised epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: An in-vitro study in Caco-2 and MDCK cell monolayers. Journal of Pharmacology and Experimental Therapeutics 307 (3) , pp. 1112-1119. 10.1124/jpet.103.056135

Campbell, Lee, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Griffiths, David Francis Rees 2003. Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. British Journal of Cancer 89 (10) , pp. 1909-1913. 10.1038/sj.bjc.6601359

Campbell, Lee, Abulrob, Abedel-Nasser G., Kandalaft, Lana, Plummer, Steven, Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Gibbs, Alan and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2003. Constitutive expression of P-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures. Journal of Pharmacology and Experimental Therapeutics 304 (1) , pp. 441-452. 10.1124/jpet.102.042994

Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Duncan, Ruth 2003. Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. Advanced Drug Delivery Reviews 55 (11) , pp. 1353-1367. 10.1016/j.addr.2003.07.002

Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Campbell, Lee, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Evans, Darrell J. R. 2002. Caveolin expression during chondrogenesis in the avian limb. Developmental Dynamics 225 (2) , pp. 205-211. 10.1002/dvdy.10143

Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924, Waterworth, C. A., Luscombe, C., Parkins, D. A. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2001. Statistical modelling of the formulation variables in non-viral gene delivery systems. Journal of Drug Targeting 9 (3) , pp. 169-184. 10.3109/10611860108997926

Ramsay, Euan, Hadgraft, Jon, Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924 and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2000. Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro. International Journal of Pharmaceutics 210 (1-2) , pp. 97-107. 10.1016/S0378-5173(00)00571-8

Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924, Kellaway, I. W. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2000. Physical stability and in-vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes. International Journal of Pharmaceutics 197 (1-2) , pp. 221-231. 10.1016/S0378-5173(00)00339-2

Birchall, James Caradoc ORCID: https://orcid.org/0000-0001-8521-6924, Marichal, C., Campbell, L., Alwan, A., Hadgraft, J. and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 2000. Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes. International Journal of Pharmaceutics 197 (1-2) , pp. 233-238. 10.1016/S0378-5173(00)00336-7

Campbell, Lee, Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Al-Eid, A., Newman, Geoff R., Von Ruhland, Christopher John and Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X 1999. Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures. Biochemical and Biophysical Research Communications 262 (3) , pp. 744-751. 10.1006/bbrc.1999.1280