T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly α/β+ and are thymus dependent

Vaage, John Torgils, Dissen, Erik, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Roberts, Ian, Fossum, Sigbjørn and Rolstad, Bent 1990. T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly α/β+ and are thymus dependent. European Journal of Immunology 20 (5) , pp. 1193-1196. 10.1002/eji.1830200538

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Abstract

Rearrangement of both the β and γ chain T cell receptor (TcR) genes was detected in intestinal intraepithelial lymphocytes (IEL) from normal euthymic rats. Flow cytometric analyses showed that about 73% of the IEL were CD3+ (1F4) and that67% were TcR α/β+ (R73). About 5% of the IEL were found to be CD3+, TcR α/β− in double-labeling experiments suggesting that a small fraction of IEL in the rat express the alternative TcR γ/δ. More than 70% of the IEL were granular implying that many CD3+ IEL are granular. In IEL from athymic nude rats no rearrangement of either the TcR β or γ chain genes or surface expression of CD3 or TcR α/β was detected despite the fact that about 95% of the cells were granular and morphologically similar to those in normal rats. Taken together our data suggest that the majority of IEL in the rat express the conventional TcR α/β and that TcR-bearingcells in the gut epithelium are thymus dependent.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	John Wiley & Sons
ISSN:	0014-2980
Last Modified:	21 Oct 2022 08:56
URI:	https://orca.cardiff.ac.uk/id/eprint/34833

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