Browse by Current Cardiff authors

Moon, Owen R., Newman, Andrew C., Alanazi, Abdullah S., Wehenkel, Sophie C., Gawel-Bęben, Katarzyna, Ivetic, Aleksandar, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2025. TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail. Journal of Biological Chemistry 301 (8) , 110473. 10.1016/j.jbc.2025.110473

Owens, Helen A., Thorburn, Lauren M., Walsby, Elisabeth ORCID: https://orcid.org/0000-0001-8523-5017, Moon, Owen R., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Sherwani, Subuhi, Tinsley, Caroline L., Rogers, Louise, Cerutti, Camilla, Ridley, Anne J., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Knäuper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20 (3) , pp. 2016-2033. 10.1002/alz.13603

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2023. Cancer immunotherapy: T cells and neutrophils working together to attack cancers. Cell 186 (7) , pp. 1304-1306. 10.1016/j.cell.2023.03.005

Champion, Jesse D., Dodd, Kayleigh M., Lam, Hilaire C., Alzahrani, Mohammad A.M., Seifan, Sara, Rad, Ellie, Scourfield, David Oliver, Fishel, Melissa L., Calver, Brian L., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Henske, Elizabeth P., Davies, D. Mark, Kelley, Mark R. and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2022. Drug inhibition of redox factor-1 restores hypoxia-driven changes in tuberous sclerosis complex 2 deficient cells. Cancers 14 (24) , 6195. 10.3390/cancers14246195

Treps, Lucas, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Hida, Kyoko 2022. Editorial: Tumor vessels as directors of the tumor microenvironment: new findings, current challenges & perspectives. Frontiers in Cell and Developmental Biology 10 , 885670. 10.3389/fcell.2022.885670

Reed, Sophie G. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2022. Immune responses to IAV infection and the roles of L-selectin and ADAM17 in lymphocyte homing. Pathogens 11 (2) , 150. 10.3390/pathogens11020150

Brown, Liam V., Gaffney, Eamonn A., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wagg, Jonathan and Coles, Mark C. 2021. Quantifying the limits of CAR T-cell delivery in mice and men. Journal of the Royal Society Interface 18 (176) , 20201013. 10.1098/rsif.2020.1013

Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x

Demaria, Maria C., Yeung, Louisa, Peeters, Rens, Wee, Janet L., Mihaljcic, Masa, Jones, Eleanor L., Nasa, Zeyad, Alderuccio, Frank, Hall, Pamela, Smith, Brodie C., Hammerling, Gunther, Kwok, Hang Fai, Newman, Andrew, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, van Spriel, Annemiek, Hickey, Michael J. and Wright, Mark D. 2020. Tetraspanin CD53 promotes lymphocyte recirculation by stablising L-selectin surface expression. iScience 23 (5) , 101104. 10.1016/j.isci.2020.101104

Cerretelli, G., Ager, A. ORCID: https://orcid.org/0000-0002-5763-8908, Arends, M. J. and Frayling, I. M. 2020. Molecular pathology of Lynch Syndrome. Journal of Pathology 250 (5) , pp. 518-531. 10.1002/path.5422

Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Svane, Inge Marie, Phillips, John D. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , 178 - 185. 10.1038/s41590-019-0578-8

Pfuderer, Pauline L., Ballhausen, A, Seidler, F, Stark, H, Grabe, N, Frayling, I, Ager, A ORCID: https://orcid.org/0000-0002-5763-8908, Doeberitz, M, Kloor, M and Ahadova, A 2019. High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer. British Journal of Cancer 121 , pp. 395-404. 10.1038/s41416-019-0514-6 Item availability restricted.

Watson, H. Angharad, Durairaj, Ruban R.P., Ohme, Julia, Alatsatianos, Markella, Almutairi, Hanan, Mohammed, Rebar N., Vigar, Miriam, Reed, Sophie G., Paisey, Stephen J. ORCID: https://orcid.org/0000-0002-2274-3708, Marshall, Christopher ORCID: https://orcid.org/0000-0002-2228-883X, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10 , 1321. 10.3389/fimmu.2019.01321

Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R. James, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 , 5487. 10.1038/s41598-019-41811-z

Seth, Sidhant, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Arends, Mark and Frayling, Ian M 2018. Lynch Syndrome - cancer pathways, heterogeneity and immune escape. Journal of Pathology 246 (2) , pp. 129-133. 10.1002/path.5139

Jones, Emma, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2018. Defining high endothelial venules and tertiary lymphoid structures in cancer. Tertiary Lymphoid Structures. Methods in Molecular Biology, Vol. 1845. Methods in Molecular Biology, Humana Press, pp. 99-118. (10.1007/978-1-4939-8709-2_7)

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Makinde, Julia, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gras, Stephanie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Burrows, Scott R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512

Gaweł-Bęben, K., Ali, N., Ellis, V., Velasco, G., Poghosyan, Z., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2018. TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. Cell Biology International 42 (3) , pp. 273-280. 10.1002/cbin.10832

Caucheteux, S.M., Hu-Li, J., Mohammed, R.N, Ager, A. ORCID: https://orcid.org/0000-0002-5763-8908 and Paul, W.E. 2017. Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant. Mucosal Immunology 10 (2) , pp. 361-372. 10.1038/mi.2016.54

Ager, Elizabeth ORCID: https://orcid.org/0000-0002-5763-8908 2017. High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function. Frontiers in Immunology 8 , 45. 10.3389/fimmu.2017.00045

Watson, H. Angharad, Dolton, Garry Michael, Ohme, Julia, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Vigar, Miriam, Wehenkel, Sophie, Hindley, James, Mohammed, Rebar, Miners, Kelly, Luckwell, Rhys A, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R James and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 (8) 10.1038/icb.2016.45

Watson, Heulwen Angharad, Wehenkel, Sophie, Matthews, James and Ager, Elizabeth ORCID: https://orcid.org/0000-0002-5763-8908 2016. SHP-1: the next checkpoint target for cancer immunotherapy? Biochemical Society Transactions 44 (2) , pp. 356-362. 10.1042/BST20150251

Ager, Elizabeth ORCID: https://orcid.org/0000-0002-5763-8908, Watson, Heulwen Angharad, Wehenkel, Sophie C. and Mohammed, Rebar N. 2016. Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells. Biochemical Society Transactions 44 (2) , pp. 377-385. 10.1042/BST20150254

Mohammed, Rebar N., Watson, H. Angharad, Vigar, Miriam, Ohme, Julia, Thomson, Amanda, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4) , pp. 760-771. 10.1016/j.celrep.2015.12.090

Ondondo, Beatrice, Colbeck, Emily, Jones, Emma, Smart, Kathryn, Lauder, Sarah Nicol, Hindley, James Philip, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Moser, Bernhard ORCID: https://orcid.org/0000-0002-4354-4572, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1) , pp. 94-104. 10.1111/imm.12430

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and May, Michael J. 2015. Understanding high endothelial venules: lessons for cancer immunology. OncoImmunology 4 (6) , e1008791. 10.1080/2162402X.2015.1008791

Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Jackson, David G., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wooldridge, Linda, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Wynn, Katherine Kay, Withers, David, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2012. ADAMs and ectododomain proteolytic shedding in leucocyte migration: Focus on L-Selectin and ADAM17. Current Immunology Reviews 8 (2) , pp. 103-117. 10.2174/157339512800099657

Klinger, A., Gebert, A., Bieber, K., Kalies, K., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Bell, E. B. and Westermann, J. 2009. Cyclical expression of L-selectin (CD62L) by recirculating T cells. International Immunology 21 (4) , pp. 443-455. 10.1093/intimm/dxp012

Anderson, Britt E., Taylor, Patricia A., McNiff, Jennifer M., Jain, Dhanpat, Demetris, Anthony J., Panoskaltsis-Mortari, Angela, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Blazar, Bruce R., Shlomchik, Warren D. and Shlomchik, Mark J. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111 (10) , pp. 5242-5251. 10.1182/blood-2007-09-107953

Sinclair, Linda V., Finlay, David, Feijoo, Carmen, Cornish, Georgina H., Gray, Alex, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Okkenhaug, Klaus, Hagenbeek, Thijs J., Spits, Hergen and Cantrell, Doreen A. 2008. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nature Immunology 9 (5) , pp. 513-521. 10.1038/ni.1603

Anderson, Britt E., Zheng, Hong, Taylor, Patricia A., Matte-Martone, Catherine, McNiff, Jennifer M., Jain, Dhanpat, Demetris, Anthony J., Panoskaltsis-Mortari, Angela, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Blazar, Bruce R., Shlomchik, Mark J. and Shlomchik, Warren D. 2008. Memory T Cells in GVHD and GVL. Biology of Blood and Marrow Transplantation 14 (Supp.1) , pp. 19-20. 10.1016/j.bbmt.2007.10.013

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Galkina, Elena, Preece, Graham and Lawrence, Michael B 2007. T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L). European Journal of Immunology 37 (5) , pp. 1243-1253. 10.1002/eji.200636481

Ivetic, Aleksander, Florey, Oliver, Deka, Jurgen, Haskard, Dorian O., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Ridley, Anne J. 2004. Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering. Journal of Biological Chemistry 279 (32) , pp. 33263-33272. 10.1074/jbc.M312212200

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Kioussis, D., Haskard, D. O. and Galkina, E. 2003. L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. Journal of Experimental Medicine 198 (9) , pp. 1323-1335. 10.1084/jem.20030485

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2003. Inflammation: border crossings. Nature 421 (6924) , pp. 703-705. 10.1038/421703a

Ivetic, Aleksander, Deka, Jurgen, Ridley, Anne and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2002. The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. The Journal of Biological Chemistry 277 (3) , pp. 2321-2329. 10.1074/jbc.M109460200

Phillips, Rhian and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2002. Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells. European Journal of Immunology 32 (3) , pp. 837-847. 10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Faveeuw, Christelle and Preece, Graham 2001. Transendothelial migration of lymphocytes across high endothelial venules into lymph nodes is affected by metalloproteinases. Blood 98 (3) , pp. 688-95. 10.1182/blood.V98.3.688

Faveeuw, Christelle, Di Mauro, Mary E., Price, Abigail A. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2000. Roles of alpha4 integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and T lymphoblasts across high endothelial venules. International Immunology 12 (3) , pp. 241-251. 10.1093/intimm/12.3.241

Derry, Catherine J., Faveeuw, Christelle, Mordsley, Kelly R. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1999. Novel chondroitin sulfate-modified ligands for L-selectin on lymph node high endothelial venules. European Journal of Immunology 29 (2) , pp. 419-430. 10.1002/(SICI)1521-4141(199902)29:02<419::AID-IMMU419>3.0.CO;2-A

Borland, Gillian, Murphy, Gillian and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1999. Tissue inhibitor of metalloproteinases-3 inhibits shedding of L-selectin from leukocytes. Journal of Biological Chemistry 274 (5) , pp. 2810-2815. 10.1074/jbc.274.5.2810

del Pozo, Miguel Angel, Cabañas, Carlos, Montoya, Maria C., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Sánchez-Mateos, Paloma and Sánchez-Madrid, Francisco 1997. ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes. Journal of Cell Biology 137 (2) , pp. 493-508. 10.1083/jcb.137.2.493

Derry, Catherine J., Mordsley, Kelly R., Preece, Graham and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1997. Purification of L-selectin ligands synthesised by rat peripheral lymph nodes and cultured high endothelial cells [Abstract]. Biochemical Society Transactions 25 (2) , 260S.

Allport, J. R., Ding, H. T., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Steeber, D. A., Tedder, T. F. and Luscinskas, F. W. 1997. L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. Journal of Immunology 158 (9) , pp. 4365-4372.

Middelhoven, P. J., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Roos, D. and Verhoeven, A. J. 1997. Involvement of a metalloprotease in the shedding of human neutrophil FcγRIIIB. FEBS Letters 414 (1) , pp. 14-18. 10.1016/S0014-5793(97)00959-9

Price, Abigail A., Cumberbatch, Marie, Kimber, Ian and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1997. α6 integrins are required for Langerhans cell migration from the epidermis. Journal of Experimental Medicine 186 (10) , pp. 1725-1735. 10.1084/jem.186.10.1725

Faveeuw, Christelle, Di Mauro, Mary and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1997. Adhesion molecules used by T lymphoblasts to interact with cultured high endothelial cells [Abstract]. Biochemical Society Transactions 25 (2) , 261S.

Preece, Graham, Murphy, Gillian and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1996. Metalloproteinase-mediated regulation of L-selectin levels on leucocytes. Journal of Biological Chemistry 271 (20) , pp. 11634-11640. 10.1074/jbc.271.20.11634

Allport, J. R., Ding, H., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Luscinskas, F. W. 1996. Inhibition of L-selectin shedding does not affect human neutrophil attachment, rolling or transendothelial migration. Molecular Biology of the Cell 7 , p. 3502.

ParraRuiz, S. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1996. Regulation of of integrins on rat lymphocytes [Abstract]. Immunology 89 (Supp1) , p. 59.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Preece, G. 1996. The regulation of lymphocyte migration across high endothelial venules [Abstract]. Immunology 89 (Supp1) , ST77.

Middelhoven, P. J., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Roos, D. and Verhoeven, A. J. 1996. Possible role of a metalloprotease in the shedding of neutrophil Fc gamma IIIb [Abstract]. Journal of Leukocyte Biology Supp S , p. 169.

Middelhoven, H., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Roos, D. and Verhoeven, A. J. 1996. Possible role of metalloprotease in the shedding of neutrophil Fc gamma RIIIb [Abstract]. Journal of Leukocyte Biology Supp S , p. 174.

Bell, Eric B., Sparshott, Sheila M. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1995. Migration pathways of CD4 T cell subsets in vivo: the CD45RC- subset enters the thymus via α4 integrin-VCAM-1 interaction. International Immunology 7 (11) , pp. 1861-1871. 10.1093/intimm/7.11.1861

Price, A. A., Kimber, I. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1995. The expression of VLA-4 and VLA-6 by langerhans cells - their potential role in regulating langerhans cell-migration[Abstract]. Journal of Investigative Dermatology 105 (6) , pp. 858-869. 10.1111/1523-1747.ep12326705

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1994. Lymphocyte recirculation and homing: roles of adhesion molecules and chemoattractants. Trends in Cell Biology 4 (9) , pp. 326-332. 10.1016/0962-8924(94)90234-8

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Preece, G. and Wood, A. C. 1994. Down-regulation of lymphocyte L-selectin on binding to high endothelium - a prerequisite for transmigration [Abstract]. Journal of Cellular Biochemistry 56 (S18A) , p. 331.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1993. Lymphocyte-vascular endothelial cell interactions in the immune response. Clinical and experimental immunology 93 (Supp 1) , pp. 5-6. 10.1111/j.1365-2249.1993.tb06213.x

May, M. J., Entwistle, G., Humphries, M. J. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1993. VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelium. Journal of Cell Science (JCS) 106 (1) , pp. 109-119.

Ensari, A., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Marsh, M. N., Morgan, S. and Moriarty, K. J. 1993. Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge. Clinical and experimental immunology 92 (2) , pp. 303-307. 10.1111/j.1365-2249.1993.tb03396.x

Hourihan, H., Allen, T. D. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1993. Lymphocyte migration across high endothelium is associated with increases in alpha 4 beta 1 integrin (VLA-4) affinity. Journal of Cell Science (JCS) 104 (4) , pp. 1049-9.

Edwards, Brian D., Slevin, Mark A., Dickson, Alan J., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Ballardie, W. 1993. Calphostin C inhibits endothelial cell proliferation and selectively modulates cell-surface marker expression [Abstract]. Biochemical Society Transactions 21 (4) , 422S. 10.1042/bst021422s

Edwards, Brian D., Slevin, Mark A., Dickson, Alan J., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Ballardie, Francis W. 1993. Antiproliferative actions of cyclosporin A on endothelial cells are not exerted through protein kinase C (PkC) [Abstract]. Biochemical Society Transactions 21 (4) , 423S. 10.1042/bst021423s

Bird, I. N., Spragg, J. H., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Matthews, N. 1993. Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO. Immunology 80 (4) , pp. 553-560.

May, Michael J. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1992. ICAM-1-independent lymphocyte transmigration across high endothelium: differential up-regulation by interferon γ, tumor necrosis factor-α and interleukin 1β. European Journal of Immunology 22 (1) , pp. 219-226. 10.1002/eji.1830220132

Ensari, A., Marsh, M. N., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Morgan, S. and Moriarty, K. J. 1992. Expression of adhesion molecules in glutenchallenged, coeliac disease (CD) rectal mucosa. Gut 33 (Supp 2) , S67.

Bradley, J. Andrew, Sarawar, Sally R., Porteous, Colin, Wood, Peter J., Card, Sharon, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Bolton, Eleanor M. and Bell, Eric B. 1992. Allograft rejection in Cd4+ T cell-reconstituted athymic nude rats-the nonessential role of host-derived Cd8+ cells1. Transplantation 53 (2) , pp. 477-482.

Szekanecz, Z., Humphries, M. J. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1992. Lymphocyte adhesion to high endothelium is mediated by two beta 1 integrin receptors for fibronectin, alpha 4 beta 1 and alpha 5 beta 1. Journal of Cell Science (JCS) 101 (4) , pp. 885-894.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Humphries, Martin J. 1991. Integrin alpha 4 beta 1: its structure, ligand-binding specificity and role in lymphocyte-endothelial cell interactions. Chemical Immunology 50 , pp. 55-74.

Vaage, John Torgils, Dissen, Erik, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Fossum, Sigbjørn and Rolstad, Bent 1991. Allospecific recognition of hemic cells in vitro by natural killer cells from athymic rats: evidence that allodeterminants coded for by single major histocompatibility complex haplotypes are recognized. European Journal of Immunology 21 (9) , pp. 2167-2175. 10.1002/eji.1830210927

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Humphries, Martin J. 1990. Use of synthetic peptides to probe lymphocyte – high endothelial cell interactions. Lymphocytes recognize a ligand on the endothelial surface which contains the CS1 adhesion motif. International Immunology 2 (10) , pp. 921-928. 10.1093/intimm/2.10.921

Vaage, John Torgils, Dissen, Erik, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Roberts, Ian, Fossum, Sigbjørn and Rolstad, Bent 1990. T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly α/β+ and are thymus dependent. European Journal of Immunology 20 (5) , pp. 1193-1196. 10.1002/eji.1830200538

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Fajumi, James, Sparshott, Sheila M., Ford, William L. and Butcher, Geoffrey W. 1988. Major histocompatibility complex control of nk-related allogeneic lymphocyte cytotoxicity in rats the contributions of strong and medial transplantation antigens. Transplantation 46 (5) , pp. 762-767.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Mistry, Shilaben 1988. Interaction between lymphocytes and cultured high endothelial cells: an in vitro model of lymphocyte migration across high endothelial venule endothelium. European Journal of Immunology 18 (8) , pp. 1265-1274. 10.1002/eji.1830180818

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Mistry, Shilaben 1988. The expression of lymphocyte adhesion molecules on cultured high endothelial cells. Advances in Experimental Medicine and Biology 237 , pp. 471-476.

Fossum, Sigbjørn, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Rolstad, B. 1987. Specific inhibition of natural killer (NK) activity against different alloantigens. Immunogenetics 26 (6) , pp. 329-338. 10.1007/BF00343700

Kumar, Shant, West, David C. and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1987. Heterogeneity in endothelial cells from large vessels and microvessels. Differentiation 36 (1) , pp. 57-70. 10.1111/j.1432-0436.1987.tb00181.x

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1987. Isolation and culture of high endothelial cells from rat lymph nodes. Journal of Cell Science (JCS) 87 (1) , pp. 133-144.

Felce, David John, Dekock, U., Thomas, M., Repp, A., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Blunden, R. 1985. Staff-client ratios and their effects on staff interactions and client behaviors [Abstract]. Bulletin of the British Psychological Society 38 , A61.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, J. L. 1984. Differential effects of hydrogen peroxide on indices of endothelial cell function. Journal of Experimental Medicine 159 (2) , pp. 592-603. 10.1084/jem.159.2.592

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wenham, D. J. and Gordon, J. L. 1984. Stimulation of endothelial cells by protease activity in commercial preparations of xanthine oxidase. Thrombosis Research 35 (1) , pp. 43-52. 10.1016/0049-3848(84)90311-6

LeRoy, E. C., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, J. L. 1984. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents. The Journal of Clinical Investigation 74 (3) , pp. 1003-1010. 10.1172/JCI111467

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, J. L. 1984. Cellular effects of proteinase activity in commercial xanthine oxidase [Letter]. Biochemical Journal 222 (3) , p. 839.

Chesterman, Colin N., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, J. L. 1983. Regulation of prostaglandin production and ectoenzyme activities in cultured aortic endothelial cells. Journal of Cellular Physiology 116 (1) , pp. 45-50. 10.1002/jcp.1041160108

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Martin, W. 1983. Loss of receptor-mediated 86Rb efflux from pig aortic endothelial cells in culture. British Journal of Pharmacology 80 (1) , pp. 5-6. 10.1111/j.1476-5381.1983.tb11040.x

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 1982. Effects of xanthine: xanthine oxidase on membrane function: an in vitro model of endothelial damage. Agents and Actions Supplements 11 , pp. 73-81.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gordon, John L., Moncada, Salvador, Pearson, Jeremy D., Salmon, John A. and Trevethick, Michael A. 1982. Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells. Journal of Cellular Physiology 110 (1) , pp. 9-16. 10.1002/jcp.1041100103

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, John L. 1981. Influence of human β-thromboglobulin on prostaglandin production by pig aortic endothelial cells in culture. Thrombosis Research 24 (1-2) , pp. 95-103. 10.1016/0049-3848(81)90035-9

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gordon, John L. 1980. Effects of vasoactive and inflammatory agents on cyclic AMP levels in W 138 fibroblasts, endothelial and vascular smooth muscle cells in culture. Agents and Actions 10 (6) , pp. 569-572.

Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Pearson, Jeremy D. and Gordon, John L. 1979. Radioimmunoassay of 6-oxoprostaglandin F1α and prostaglandin E2 produced by pig aortic endothelium in culture [Abstract]. Biochemical Society Transactions 7 (5) , pp. 1065-1066. 10.1042/bst0071065

Pearson, Jeremy D., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Trevethick, M. A. and Gordon, John L. 1979. Prostaglandin production by cultured vascular cells. Agents and Actions Supplements 4 , pp. 120-126.