Komai-Koma, Mousa, Gracie, J. Alastair, Wei, Xiao-Qing ![]() |
Abstract
Cell locomotion is crucial to the induction of an effective immune response. We report here the chemoattraction of CD4� T cells by IL-18, a member of the IL-1 cytokine family. Recombinant IL-18 increased the proportion of T cells in polarized morphology in vitro and stimulated their subsequent invasion into collagen gels in an IL-18 concentration gradient-dependent manner. Immunofluorescent microscopy studies determined that the major cell type responding to IL-18 was IL-18R�CD4�. Importantly, synovial CD4� T cells from patients with rheumatoid arthritis responded to IL-18, adopting polarized morphology and gel invasion without further activation ex vivo, indicating the physiologic relevance of our observations. Finally, injection of rIL-18 into the footpad of DBA/1 mice led to local accumulation of inflammatory cells. These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Dentistry |
Subjects: | Q Science > QR Microbiology > QR180 Immunology |
Publisher: | American Association of Immunologists |
ISSN: | 0022-1767 |
Last Modified: | 21 Oct 2022 09:14 |
URI: | https://orca.cardiff.ac.uk/id/eprint/35692 |
Citation Data
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