Chemoattraction of human T cells by IL-18

Komai-Koma, Mousa, Gracie, J. Alastair, Wei, Xiao-Qing ORCID: https://orcid.org/0000-0002-6274-8503, Xu, Damo, Thomson, Neil, McInnes, Iain B. and Liew, Foo Yew 2003. Chemoattraction of human T cells by IL-18. The Journal of Immunology 170 (2) , pp. 1084-1090.

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Abstract

Cell locomotion is crucial to the induction of an effective immune response. We report here the chemoattraction of CD4� T cells by IL-18, a member of the IL-1 cytokine family. Recombinant IL-18 increased the proportion of T cells in polarized morphology in vitro and stimulated their subsequent invasion into collagen gels in an IL-18 concentration gradient-dependent manner. Immunofluorescent microscopy studies determined that the major cell type responding to IL-18 was IL-18R�CD4�. Importantly, synovial CD4� T cells from patients with rheumatoid arthritis responded to IL-18, adopting polarized morphology and gel invasion without further activation ex vivo, indicating the physiologic relevance of our observations. Finally, injection of rIL-18 into the footpad of DBA/1 mice led to local accumulation of inflammatory cells. These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Last Modified:	21 Oct 2022 09:14
URI:	https://orca.cardiff.ac.uk/id/eprint/35692

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