T cell subsets and colorectal cancer: discerning the good from the bad

Scurr, Martin John ORCID: https://orcid.org/0000-0002-4120-0688, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2012. T cell subsets and colorectal cancer: discerning the good from the bad. Cellular Immunology 279 (1) , pp. 21-24. 10.1016/j.cellimm.2012.08.004

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Abstract

Tumor-specific T cells must overcome a multitude of suppressive mechanisms to destroy cancerous cells effectively. Furthermore, it appears that the tumor microenvironment facilitates the development of highly immunosuppressive T cells, which may also allow subsequent tumor progression. In colorectal cancer, the relationship between regulatory T cells (e.g. FoxP3(+) Tregs) and tumor prognosis and progression is less clear, despite their well-documented ability to impinge on anti-tumor immune responses. Here we explore our current knowledge of colorectal TIL heterogeneity, deciphering subsets which may be of benefit or detriment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Colorectal cancer; T cells; Regulatory T cells
Publisher:	Elsevier
ISSN:	0008-8749
Last Modified:	21 Oct 2022 10:25
URI:	https://orca.cardiff.ac.uk/id/eprint/40136

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