Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice

Kokhan, V. S., Bolkunov, A. V., Ustiugov, A. A., Van'kin, G. I., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Redkozubova, O. M., Strekalova, T. V., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Bachurin, S. O. 2012. Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice. Neuroscience and Behavioral Physiology 42 (6) , pp. 575-581. 10.1007/s11055-012-9603-1

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Abstract

Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons located in brain areas responsible for forming emotions and memory. However, the involvement of γ-synucleins in controlling neuronal and synaptic processes underlying various types of behavior in humans and animals have not yet been studied. We provide the first demonstration that the absence of γ-synuclein increases orientational-investigative activity in a novel context and decreases the level of situational anxiety in animals.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Springer
ISSN:	0097-0549
Last Modified:	09 Jun 2023 06:44
URI:	https://orca.cardiff.ac.uk/id/eprint/41844

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