Aryl azide photochemistry in defined protein environments

Morris, Josephine Lydia, Reddington, Samuel C., Murphy, Damien Martin ORCID: https://orcid.org/0000-0002-5941-4879, Jones, Darran Dafydd ORCID: https://orcid.org/0000-0001-7709-3995, Platts, James Alexis ORCID: https://orcid.org/0000-0002-1008-6595 and Tippmann, Eric Michael 2013. Aryl azide photochemistry in defined protein environments. Organic Letters 15 (4) , pp. 728-731. 10.1021/ol3028779

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Abstract

A genetically encoded precursor to an aryl nitrene, para-azidophenylalanine, was introduced site specifically into proteins to deduce if distinct environments were capable of caging a reactive organic intermediate. Following photolysis of mutant T4 lysozyme or green fluorescent proteins, EPR spectra showed, respectively, the presence of a triplet nitrene and an anilino radical.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	ACS
ISSN:	1523-7060
Funders:	EPSRC
Last Modified:	16 Oct 2024 10:18
URI:	https://orca.cardiff.ac.uk/id/eprint/45499

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