Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David Glyn 2005. Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing. Biogerontology 6 (6) , pp. 371-385. 10.1007/s10522-005-4901-4

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Abstract

Studies on telomere and telomerase biology are fundamental to the understanding of human ageing and age-related diseases such as cancer. However, human studies of whole body ageing are hampered by the lack of suitable fully reflective animal model systems, the wild-type mouse model being unsuitable due to differences in telomere biology. Here we summarise recent data on the biology of telomeres, telomerase, and the tumour suppressor protein p53 in various animals, and examine their possible roles in replicative senescence, ageing, and tumourigenesis. The advantages and disadvantages of various animals as model systems for whole body ageing in humans are discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	cellular immortalisation; hTERT; p21WAF1; p53; primates; sheep; tumourigenesis
Publisher:	Springer
ISSN:	1389-5729
Last Modified:	14 Dec 2022 02:15
URI:	https://orca.cardiff.ac.uk/id/eprint/46695

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