Browse by Current Cardiff authors

Alimbetov, D., Umbayev, B., Tsoy, A., Begimbetova, D., Davis, T. ORCID: https://orcid.org/0000-0003-2780-0262, Kipling, D. and Askarova, Sh. 2023. Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment. BMC Cancer 23 (1) , 895. 10.1186/s12885-023-11319-x

Hayes, Mark David, Ward, Sophie, Crawford, Greg, Seoane, Rocio Castro, Jackson, William David, Kipling, David, Voehringer, David, Dunn-Walters, Deborah and Strid, Jessica 2020. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. eLife 9 , e51862. 10.7554/eLife.51862

Crawford, Greg, Hayes, Mark David, Seoane, Rocio Castro, Ward, Sophie, Dalessandri, Tim, Lai, Chester, Healy, Eugene, Kipling, David, Proby, Charlotte, Moyes, Colin, Green, Kile, Best, Katie, Haniffa, Muzlifah, Botto, Marina, Dunn-Walters, Deborah and Strid, Jessica 2018. Epithelial damage and tissue T cells promote a unique tumor-protective IgE response. Nature Immunology 19 (8) , pp. 859-870. 10.1038/s41590-018-0161-8

Caley, Matthew, Wall, Ivan, Peake, Matthew, Kipling, David, Giles, Peter ORCID: https://orcid.org/0000-0003-3143-6854, Thomas, David and Stephens, Phil ORCID: https://orcid.org/0000-0002-0840-4996 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19 (4) , 1001. 10.3390/ijms19041001

Sáez de Guinoa, Julia, Jimeno, Rebeca, Gaya, Mauro, Kipling, David, Garzón, María José, Dunn-Walters, Deborah, Ubeda, Carles and Barral, Patricia 2018. CD1d‐mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis. EMBO Journal 37 (5) , e97537. 10.15252/embj.201797537

Björkman, Andrea, Du, Likun, van der Burg, Mirjam, Cormier-Daire, Valerie, Borck, Guntram, Pié, Juan, Anderlid, Britt-Marie, Hammarström, Lennart, Ström, Lena, de Villartay, Jean-Pierre, Kipling, David, Dunn Walters, Deborah and Pan-Hammarström, Qiang 2018. Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome [Letter to the Editor]. Journal of Allergy and Clinical Immunology 141 (1) , 408-411.e8. 10.1016/j.jaci.2017.06.043

Alimbetov, Dauren, Askarova, Sholpan, Umbayev, Bauyrzhan, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David 2018. Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells. International Journal of Molecular Sciences 19 (6) , p. 1690. 10.3390/ijms19061690

Martin, Victoria G., Wu, Yu-Chang Bryan, Townsend, Catherine L., Lu, Grace H. C., O'Hare, Joselli Silva, Mozeika, Alexander, Coolen, Anthonius C. C., Kipling, David, Fraternali, Franca and Dunn-Walters, Deborah K. 2016. Transitional B cells in early human B cell development - time to revisit the paradigm? Frontiers in Immunology 7 , 546. 10.3389/fimmu.2016.00546

Townsend, Catherine L., Laffy, Julie M. J., Wu, Yu-Chang Bryan, Silva O'Hare, Joselli, Martin, Victoria, Kipling, David Glyn, Fraternali, Franca and Dunn-Walters, Deborah K. 2016. Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions. Frontiers in Immunology 7 10.3389/fimmu.2016.00388

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Brook, Amy Jayne Chedzoy, Rokicki, Michal Jaroslaw, Bagley, Mark and Kipling, David Glyn 2016. Evaluating the role of p38 MAPK in the accelerated cell senescence of Werner syndrome fibroblasts. Pharmaceuticals 9 (2) , 23. 10.3390/ph9020023

Alimbetov, Dauren, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Brook, Amy J. C., Cox, Lynne S., Faragher, Richard G. A., Nurgozhin, Talgat, Zhumadilov, Zhaxybay and Kipling, David Glyn 2016. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 17 , 305. 10.1007/s10522-015-9610-z

Bagley, Mark C., Dwyer, Jessica E., Baashen, Mohammed, Dix, Matthew C., Murziani, Paola G. S., Rokicki, Michal J., Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2016. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Organic & Biomolecular Chemistry 14 (3) , pp. 947-956. 10.1039/C5OB02229K

Martin, Victoria, Wu, Yu-Chang, Kipling, David Glyn and Dunn-Walters, Deborah K. 2015. Age-related aspects of human IgM+ B cell heterogeneity. Annals of the New York Academy of Sciences 1362 , pp. 153-163. 10.1111/nyas.12823

Martin, Victoria, (Bryan) Wu, Yu-Chang, Kipling, David and Dunn-Walters, Deborah 2015. Ageing of the B-cell repertoire. Philosophical Transactions of the Royal Society B: Biological Sciences 370 (1676) , 20140237. 10.1098/rstb.2014.0237

Bagley, Mark, Baashen, Mohammed, Chuckowree, Irina, Dwyer, Jessica, Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2015. Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner Syndrome Cells. Pharmaceuticals 8 (2) , pp. 257-276. 10.3390/ph8020257

Tete, Sarah M., Kipling, David Glyn, Westra, Johanna, de Haan, Aalzen, Bijl, Marc, Dunn-Walters, Deborah K., Sahota, Surinder S. and Bos, Nicolaas A. 2015. Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response. Experimental Hematology 43 (6) , pp. 439-447. 10.1016/j.exphem.2015.02.005

Hehle, Verena, Fraser, Louise D., Tahir, Romeeza, Kipling, David, Wu, Yu-Chang, Lutalo, Pamela M.K., Cason, John, Choong, LeeMeng, D'Cruz, David P., Cope, Andrew P., Dunn-Walters, Deborah K. and Spencer, Jo 2015. Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus. Molecular Immunology 65 (2) , pp. 215-223. 10.1016/j.molimm.2015.01.017

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Tivey, Hannah S.E., Brook, Amy J.C. and Kipling, David 2015. Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence. Biogerontology 16 (1) , pp. 43-51. 10.1007/s10522-014-9530-3

Wu, Yu-Chang, Kipling, David and Dunn-Walters, Deborah 2015. Assessment of B Cell Repertoire in Humans. Shaw, Albert C., ed. Immunosenescence: Methods and Protocols, Vol. 1343. Methods in Molecular Biology, New York: Humana Press, pp. 199-218. (10.1007/978-1-4939-2963-4_16)

Wu, Yu-Chang B., James, Louisa K., Vander Heiden, Jason A., Uduman, Mohamed, Durham, Stephen R., Kleinstein, Steven H., Kipling, David and Gould, Hannah J. 2014. Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis. Journal of Allergy and Clinical Immunology 134 (3) , pp. 604-612. 10.1016/j.jaci.2014.07.010

Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L., Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D., Brink, Robert, Dunn-Walters, Deborah K., Christ, Daniel and Goodnow, Christopher C. 2014. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. Proceedings of the National Academy of Sciences 111 (25) , E2567-E2575. 10.1073/pnas.1406974111

Peake, Matthew A., Caley, Mathew, Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Wall, Ivan B., Enoch, Stuart, Davies, Lindsay Catrina ORCID: https://orcid.org/0000-0002-4876-6270, Kipling, David Glyn, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22 (3) , pp. 399-405. 10.1111/wrr.12170

Broccoli, D, Shaker, M, Pascarelli, K, Plantinga, M, Love, M, Lazar, A, Ingram, R, von Mehren, M, Lev, D and Kipling, David Glyn 2014. Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas. Biomarkers in Cancer 6 , pp. 1-10. 10.4137/BIC.S14683

Mark, Bagley, Mohammed, Baashen, Jessica, Dwyer, Pierre, Milbeo, Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2014. Microwave-assisted Synthesis of Inhibitors of MK2 for Targeting p38 MAP Kinase Signalling in Werner Syndrome Cells. John, Spencer and Mark, Bagley, eds. Microwaves in Drug Discovery and Development: Recent Advances, London: Future Medicine Ltd, pp. 86-104. (10.4155/fseb2013.13.130)

Bagley, Mark C., Baashen, Mohammed, Paddock, Victoria L., Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2013. Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors. Tetrahedron 69 (39) , pp. 8429-8438. 10.1016/j.tet.2013.07.055

de Miranda, Noel F. C. C., Peng, Roujun, Georgiou, Konstantinos, Wu, Chenglin, Sorqvist, Elin Falk, Berglund, Mattias, Chen, Longyun, Gao, Zhibo, Lagerstedt, Kristina, Lisboa, Susana, Roos, Fredrik, van Wezel, Tom, Teixeira, Manuel R., Rosenquist, Richard, Sundstrom, Christer, Enblad, Gunilla, Nilsson, Mats, Zeng, Yixin, Kipling, David Glyn and Pan-Hammarstrom, Qiang 2013. DNA repair genes are selectively mutated in diffuse large B cell lymphomas. Journal of Experimental Medicine 210 (9) , pp. 1729-1742. 10.1084/jem.20122842

Kenessary, Almas, Zhumadilov, Zhaxybay, Nurgozhin, Talgat, Kipling, David Glyn, Yeoman, Mark, Cox, Lynne, Ostler, Elizabeth and Faragher, Richard 2013. Biomarkers, interventions and healthy ageing. New Biotechnology 30 (4) , pp. 373-377. 10.1016/j.nbt.2012.11.018

Tivey, Hannah S. E., Brook, Amy Jayne Chedzoy, Rokicki, Michal Jaroslaw, Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2013. p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes. Biogerontology 14 (1) , pp. 47-62. 10.1007/s10522-012-9407-2

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Rokicki, Michal Jaroslaw, Bagley, Mark C. and Kipling, David Glyn 2013. The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. Chemistry Central Journal 7 , 18. 10.1186/1752-153X-7-18

Tivey, Hannah S. E., Rokicki, Michal Jaroslaw, Barnacle, James R., Rogers, Mathew James, Bagley, Mark C., Kipling, David Glyn and Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 2013. Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 68 (9) , pp. 1001-1009. 10.1093/gerona/gls336

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Tivey, Hannah, Brook, Amy Jayne Chedzoy, Grimstead, Julia W., Rokicki, Michal Jaroslaw and Kipling, David Glyn 2013. Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome. AGE 35 (5) , pp. 1767-1783. 10.1007/s11357-012-9476-9

Wu, Yu-Chang Bryan, Kipling, David Glyn and Dunn-Walters, Deborah K. 2012. Age-related changes in human peripheral blood IGH repertoire following vaccination. Frontiers in Immunology 3 , 193. 10.3389/fimmu.2012.00193

Doyle, K. R., Mitchell, M. A., Roberts, C. L., James, S., Johnson, J. E., Zhou, Y., von Mehren, M., Lev, D., Kipling, David Glyn and Broccoli, D. 2012. Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanisms [Letter]. Oncogene 31 (2) , pp. 265-266. 10.1038/onc.2011.225

Sheerin, Angela N., Smith, Susan Kaye, Jennert-Burston, Katrin, Brook, Amy Jayne Chedzoy, Allen, Marcus C., Ibrahim, Badr, Jones, Dawn, Wallis, Corrin, Engelmann, Katrin, Rhys-Williams, William, Faragher, Richard G. A. and Kipling, David Glyn 2012. Characterization of cellular senescence mechanisms in human corneal endothelial cells. Aging Cell 11 (2) , pp. 234-240. 10.1111/j.1474-9726.2011.00776.x

Ademokun, Alexander, Wu, Yu-Chang, Martin, Victoria, Mitra, Rajive, Sack, Ulrich, Baxendale, Helen, Kipling, David Glyn and Dunn-Walters, Deborah K. 2011. Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell 10 (6) , pp. 922-930. 10.1111/j.1474-9726.2011.00732.x

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew Charles, Rokicki, Michal Jaroslaw, Brook, Amy Jayne Chedzoy, Widdowson, Caroline Susan, Kipling, David Glyn and Bagley, Mark Christopher 2011. Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors. Chemistry Central Journal 5 (1) , pp. 83-88. 10.1186/1752-153X-5-83

Di Mitri, Diletta, Azevedo, Rita I., Henson, Sian M., Libri, Valentina, Riddell, Natalie E., Macaulay, Richard, Kipling, David, Soares, Maria V. D., Battistini, Luca and Akbar, Arne N. 2011. Reversible senescence in human CD4+CD45RA+CD27- memory T cells. The Journal of Immunology 187 (5) , pp. 2093-2100. 10.4049/jimmunol.1100978

Latimer, Joanna Elizabeth, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Bagley, Mark Christopher and Kipling, David Glyn 2011. Ageing science, health care and social inclusion of older people. Quality in Ageing and Older Adults 12 (1) , pp. 11-16. 10.5042/qiaoa.2011.0140

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Latimer, Joanna Elizabeth and Kipling, David Glyn 2011. The contribution of biogerontology to quality ageing. Quality in Ageing and Older Adults 12 (1) , pp. 26-32. 10.5042/qiaoa.2011.0142

Enoch, Stuart, Peake, Matthew Arnold, Wall, Ivan Bernard, Davies, Lindsay Catrina ORCID: https://orcid.org/0000-0002-4876-6270, Farrier, Jerry N., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Kipling, David Glyn, Price, Patricia Elaine, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89 (12) , pp. 1407-1413. 10.1177/0022034510377796

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew, Fusillo, Vincenzo, Pigeaux, Morgane, Rokicki, Michal Jaroslaw and Kipling, David Glyn 2010. Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome. Future Medicinal Chemistry 2 (9) , pp. 1417-1427. 10.4155/fmc.10.217

Wu, Yu-Chang, Kipling, David Glyn, Leong, Hui Sun, Martin, Victoria, Ademokun, Alexander A. and Dunn-Walters, Debra K. 2010. High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood 116 (7) , pp. 1070-1078. 10.1182/blood-2010-03-275859

Bagley, Mark C., Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Murziani, Paola G. S., Widdowson, Caroline and Kipling, David Glyn 2010. Use of p38 MAPK inhibitors for the treatment of Werner Syndrome. Pharmaceuticals 3 (6) , pp. 1842-1872. 10.3390/ph3061842

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Rokicki, Michal Jaroslaw, Widdowson, Caroline Susan and Kipling, David Glyn 2010. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Medicinal Chemistry 2 (2) , pp. 193-201. 10.4155/fmc.09.163

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew Charles, Murziani, Paola G. S., Rokicki, Michal Jaroslaw and Kipling, David Glyn 2010. Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells. Future Medicinal Chemistry 2 (2) , pp. 203-213. 10.4155/fmc.09.160

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Bachler, Marcus Aurelius, Wyllie, Fiona Sandra, Bagley, Mark Christopher and Kipling, David 2010. Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1197 (1) , pp. 45-48. 10.1111/j.1749-6632.2010.05195.x

Mitchell, M. A., Johnson, J. E., Pascarelli, K., Beeharry, N., Chiourea, M., Gagos, S., Lev, D., von Mehren, M., Kipling, David Glyn and Broccoli, D. 2010. Doxorubicin resistance in a novel in vitro model of human pleomorphic liposarcoma associated with alternative lengthening of telomeres. Molecular Cancer Therapeutics 9 (3) , pp. 682-692. 10.1158/1535-7163.MCT-09-0705

Enoch, Stuart, Wall, Ivan Bernard, Peake, Matthew Arnold, Davies, Lindsay Catrina ORCID: https://orcid.org/0000-0002-4876-6270, Farrier, Jerry N., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Kipling, David Glyn, Price, Patricia Elaine, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88 (10) , pp. 916-921. 10.1177/0022034509342979

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Tivey, Hannah S. E. and Kipling, David 2009. Telomere dynamics and biology in human progeroid syndromes. Mancini, Leonardo, ed. Telomeres: Function, Shortening and Lengthening, New York: Nova Science Publishers, Inc., pp. 1-75.

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David Glyn 2009. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts. Biogerontology 10 (3) , pp. 253-266. 10.1007/s10522-008-9179-x

Gibson, Kate L., Wu, Yu-Chang, Barnett, Yvonne, Duggan, Orla, Vaughan, Robert, Kondeatis, Elli, Nilsson, Bengt-Olof, Wikby, Anders, Kipling, David Glyn and Dunn-Walters, Deborah K. 2009. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 8 (1) , pp. 18-25. 10.1111/j.1474-9726.2008.00443.x

Burton, Dominick G. A., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Sheerin, Angela N.P., Smith, Susan Kaye, Lawton, Jessica J., Ostler, Elizabeth L., Rhys-Williams, William, Kipling, David Glyn and Faragher, Richard G. A. 2009. Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification. Experimental Gerontology 44 (10) , pp. 659-665. 10.1016/j.exger.2009.07.004

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew Charles, Fusillo, Vincenzo, Pigeaux, Morgane, Rokicki, Michal Jaroslaw and Kipling, David Glyn 2009. Microwave-assisted Ullmann C-S bond formation: synthesis of the P38 alpha MAPK clinical candidate VX-745. Journal of Organic Chemistry 74 (21) , pp. 8336-8342. 10.1021/jo9017155

Leong, Hui Sun and Kipling, David Glyn 2009. Text-based over-representation analysis of microarray gene lists with annotation bias. Nucleic Acids Research 37 (11) , e79-e79. 10.1093/nar/gkp310

Kipling, David Glyn, Jones, Dawn L., Smith, Susan Kaye, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Jennert-Burston, Katrin, Ibrahim, Badr, Sheerin, Angela N.P., Evans, Amy J. C., Rhys-Willams, William and Faragher, Richard G.A. 2009. A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence. Experimental Eye Research 88 (2) , pp. 277-285. 10.1016/j.exer.2008.11.030

Wall, Ivan Bernard, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Kipling, David Glyn, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Laffafian, Iraj, Price, Patricia Elaine, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128 (10) , pp. 2526-2540. 10.1038/jid.2008.114

Peake, Matthew Arnold, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Wall, Ivan Bernard, Enoch, Stuart, Kipling, David Glyn, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16 (6) , A71. 10.1111/j.1524-475X.2008.00424.x

Duce, James A., Podvin, Sonia, Hollander, William, Kipling, David Glyn, Rosene, Douglas L. and Abraham, Carmela R. 2008. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56 (1) , pp. 106-117. 10.1002/glia.20593

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, M. C., Murziani, Paola G. S., Rokicki, Michal Jaroslaw and Kipling, David Glyn 2008. Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 18 (13) , pp. 3745-3748. 10.1016/j.bmcl.2008.05.037

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew, Rokicki, Michal Jaroslaw and Kipling, David Glyn 2007. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Biorganic and Medicinal Chemistry Letters 17 (18) , pp. 5107-5110. 10.1016/j.bmcl.2007.07.016

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Wyllie, Fiona Sandra, Rokicki, Michal J., Bagley, Mark C. and Kipling, David Glyn 2007. The Role of Cellular Senescence in Werner Syndrome: Toward Therapeutic Intervention in Human Premature Aging. Annals of the New York Academy of Sciences 1100 , pp. 455-469. 10.1196/annals.1395.051

Davis, Terence. ORCID: https://orcid.org/0000-0003-2780-0262, Bagley, Mark Christopher, Dix, M. C., Murziani, Paola G. S., Rokicki, M. J., Widdowson, C. S., Zayed, J. M., Bachler, M. A. and Kipling, David Glyn 2007. Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38 alpha(MAPK) inhibitors in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 17 (24) , pp. 6832-6835. 10.1016/j.bmcl.2007.10.036

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David Glyn 2007. Werner syndrome, telomeres, and stress signaling: implications for future therapies? Rudolph, K. Lenhard, ed. Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing, Springer, pp. 285-308.

Bagley, Mark C., Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew C., Widdowson, Caroline S. and Kipling, David Glyn 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry 4 (22) , pp. 4158-4164. 10.1039/b611493h

Bagley, Mark Christopher, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Dix, Matthew Charles, Widdowson, Caroline S. and Kipling, David Glyn 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38 inhibitor BIRB 796 for study into accelerated cell ageing. Organic & biomolecular chemistry 4 (22) , pp. 4158-4164. 10.1039/b611493h

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David Glyn 2006. Werner Syndrome as an example of inflamm-aging: Possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Research 9 (3) , pp. 402-407. 10.1089/rej.2006.9.402

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Haughton, Michele F., Jones, Christopher J. and Kipling, David Glyn 2006. Prevention of accelerated cell aging in the Werner syndrome. Annals of the New York Academy of Sciences 1067 (1) , pp. 243-247. 10.1196/annals.1354.031

Britt-Compton, Bethan, Rowson, Janet Maud, Locke, Matthew, Mackenzie, Ian, Kipling, David Glyn and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2006. Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Human Molecular Genetics 15 (5) , pp. 725-733. 10.1093/hmg/ddi486

Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Britt-Compton, Bethan, Rowson, Janet Maud, Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623, Gregory, Linda and Kipling, David Glyn 2006. Telomere instability in the male germline. Human molecular genetics 15 (1) , pp. 45-51. 10.1093/hmg/ddi424

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262 and Kipling, David Glyn 2005. Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing. Biogerontology 6 (6) , pp. 371-385. 10.1007/s10522-005-4901-4

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Haughton, Michele Fleur, Jones, Christopher John and Kipling, David Glyn 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60 (11) , pp. 1386-93.

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Skinner, Julia W., Faragher, Richard G. A., Jones, Christopher J. and Kipling, David Glyn 2005. Replicative senescence in sheep fibroblasts is a p53 dependent process. Experimental Gerontology 40 (1-2) , pp. 17-26. 10.1016/j.exger.2004.09.004

Kipling, David Glyn, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Ostler, Elizabeth L. and Faragher, Richard G. A. 2004. What can progeroid syndromes tell us about human aging? Science 305 (5689) , pp. 1426-1431. 10.1126/science.1102587

Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Rowson, Janet Maud, Jones, Christopher John and Kipling, David Glyn 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13 (14) , pp. 1515-1524. 10.1093/hmg/ddh159

Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996, Grenard, Pascale Marie, Aeschlimann, Pascale Corinne, Langley, Martin Simon, Blain, Emma Jane ORCID: https://orcid.org/0000-0001-8944-4254, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376, Kipling, David Glyn, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117 (15) , pp. 3389-3403. 10.1242/jcs.01188

Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 and Kipling, David Glyn 2004. The extent and significance of telomere loss with age. Annals of the New York Academy of Sciences 1019 (1) , pp. 265-268. 10.1196/annals.1297.044

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Faragher, Richard G. A., Jones, Christopher J. and Kipling, David Glyn 2004. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1019 (1) , pp. 274-277. 10.1196/annals.1297.046

Preto, Ana, Singhrao, Simarjit Kaur, Haughton, Michele Fleur, Kipling, David Glyn, Wynford-Thomas, David and Jones, Christopher John 2004. Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy. Oncogene 23 (23) , pp. 4136-4145. 10.1038/sj.onc.1207564

Evans, Rebecca Jane, Wyllie, Fiona Sandra, Wynford-Thomas, David, Kipling, David Glyn and Jones, Christopher John 2003. A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development. Cancer Research 63 (16) , pp. 4854-4861.

Sviderskaya, Elena V., Gray-Schopfer, Vanessa C., Hill, Simon P., Smit, Nico P., Evans-Whipp, Tracy J., Bond, Jane Ann, Hill, Lucy, Bataille, Veronique, Peters, Gordon, Kipling, David Glyn, Wynford-Thomas, David and Bennett, Dorothy C. 2003. p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. Journal of the National Cancer Institute 95 (10) , pp. 723-732. 10.1093/jnci/95.10.723

Davis, Terence ORCID: https://orcid.org/0000-0003-2780-0262, Singhrao, Simarjit Kaur, Wyllie, Fiona Sandra, Haughton, Michele Fleur, Smith, Paul James, Wiltshire, Marie, Wynford-Thomas, David, Jones, Christopher John, Faragher, Richard G. A. and Kipling, David Glyn 2003. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. Journal of Cell Science (JCS) 116 (7) , pp. 1349-57. 10.1242/jcs.00331

Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996, Cook, Helen, Hilton, Joanne, Jones, Christopher John, Haughton, Michele Fleur, Wyllie, Fiona Sandra, Skinner, Julia W., Harding, Keith Gordon, Kipling, David Glyn and Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283 (1) , pp. 22-35. 10.1016/S0014-4827(02)00021-6

Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Rowson, Janet Maud, Wynford-Thomas, David and Kipling, David Glyn 2003. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nature Genetics 33 (2) , pp. 203-207. 10.1038/ng1084