Parthimos, Dimitris ![]() |
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Abstract
The effects of pharmacological interventions that modulate Ca2+ homeodynamics and membrane potential in rat isolated cerebral vessels during vasomotion (i.e., rhythmic fluctuations in arterial diameter) were simulated by a third-order system of nonlinear differential equations. Independent control variables employed in the model were [Ca2+] in the cytosol, [Ca2+] in intracellular stores, and smooth muscle membrane potential. Interactions between ryanodine- and inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ stores and transmembrane ion fluxes via K+ channels, Cl? channels, and voltage-operated Ca2+ channels were studied by comparing simulations of oscillatory behavior with experimental measurements of membrane potential, intracellular free [Ca2+] and vessel diameter during a range of pharmacological interventions. The main conclusion of the study is that a general model of vasomotion that predicts experimental data can be constructed by a low-order system that incorporates nonlinear interactions between dynamical control variables.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
ISSN: | 1542-0086 |
Last Modified: | 16 May 2023 03:21 |
URI: | https://orca.cardiff.ac.uk/id/eprint/47 |
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