Parthimos, Dimitris  ORCID: https://orcid.org/0000-0003-3852-323X, Haddock, R. E., Hill, C. E. and Griffith, Tudor Morley
2007.
Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment.
Biophysical Journal
93
(5)
, pp. 1534-1556.
10.1529/biophysj.107.106278
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Abstract
The effects of pharmacological interventions that modulate Ca2+ homeodynamics and membrane potential in rat isolated cerebral vessels during vasomotion (i.e., rhythmic fluctuations in arterial diameter) were simulated by a third-order system of nonlinear differential equations. Independent control variables employed in the model were [Ca2+] in the cytosol, [Ca2+] in intracellular stores, and smooth muscle membrane potential. Interactions between ryanodine- and inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ stores and transmembrane ion fluxes via K+ channels, Cl? channels, and voltage-operated Ca2+ channels were studied by comparing simulations of oscillatory behavior with experimental measurements of membrane potential, intracellular free [Ca2+] and vessel diameter during a range of pharmacological interventions. The main conclusion of the study is that a general model of vasomotion that predicts experimental data can be constructed by a low-order system that incorporates nonlinear interactions between dynamical control variables.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| ISSN: | 1542-0086 |
| Last Modified: | 16 May 2023 03:21 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/47 |
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