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Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment

Parthimos, Dimitris, Haddock, R. E., Hill, C. E. and Griffith, Tudor Morley 2007. Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment. Biophysical Journal 93 (5) , pp. 1534-1556. 10.1529/biophysj.107.106278

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The effects of pharmacological interventions that modulate Ca2+ homeodynamics and membrane potential in rat isolated cerebral vessels during vasomotion (i.e., rhythmic fluctuations in arterial diameter) were simulated by a third-order system of nonlinear differential equations. Independent control variables employed in the model were [Ca2+] in the cytosol, [Ca2+] in intracellular stores, and smooth muscle membrane potential. Interactions between ryanodine- and inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ stores and transmembrane ion fluxes via K+ channels, Cl? channels, and voltage-operated Ca2+ channels were studied by comparing simulations of oscillatory behavior with experimental measurements of membrane potential, intracellular free [Ca2+] and vessel diameter during a range of pharmacological interventions. The main conclusion of the study is that a general model of vasomotion that predicts experimental data can be constructed by a low-order system that incorporates nonlinear interactions between dynamical control variables.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 1542-0086
Last Modified: 04 Jun 2017 01:30

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