Richardson, Ciaran Joseph, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Powell, Martin B., Prince, Stuart N., Chen, Yun-Hsiang, Spiller, O. Brad and Rowe, Martin 2005. Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and αvβ5 integrin expression. Journal of General Virology 86 (6) , pp. 1669-1679. 10.1099/vir.0.80806-0 |
Abstract
Human lymphocytes are resistant to genetic modification, particularly from recombinant adenoviruses, thus hampering the analysis of gene function using adenoviral vectors. This study engineered an Epstein–Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie–adenovirus receptor and αvβ5 integrin in mediating entry of adenoviruses into these cells. The work identified a strategy for engineering B cells to become susceptible to adenovirus infection and showed that such a strategy could be useful for the introduction of genes to alter lymphoblastoid-cell gene expression.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Publisher: | Society for General Microbiology |
ISSN: | 0022-1317 |
Last Modified: | 25 Oct 2022 09:05 |
URI: | https://orca.cardiff.ac.uk/id/eprint/57192 |
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