Latent membrane protein 1 inhibits Epstein-Barr virus lytic cycle induction and progress via different mechanisms

Prince, S., Keating, S., Fielding, C., Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Floettmann, E. and Rowe, Martin 2003. Latent membrane protein 1 inhibits Epstein-Barr virus lytic cycle induction and progress via different mechanisms. Journal of Virology 77 (8) , pp. 5000-5007. 10.1128/JVI.77.8.5000-5007.2003

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Abstract

Epstein-Barr virus (EBV) is a potent growth-transforming agent of human B cells. It has previously been shown that viral latent membrane protein 1 (LMP1) is essential for EBV-induced transformation of normal B cells and contributes to maintenance of latency in vitro. Using the EBV-positive Burkitt's lymphoma line P3HR1-c16, which lacks LMP1 during latency and which can readily be activated into virus-productive lytic cycle, we found that LMP1 inhibits lytic cycle induction via the transcription factor NF-κB. In addition, LMP1 inhibits lytic cycle progress via two distinct NF-κB-independent mechanisms: one involving the cytosolic C-terminal activating regions and the other involving the transmembrane region of LMP1. These findings indicate that in B cells EBV self-limits its lytic cycle via three distinct LMP1-mediated mechanisms.

Item Type:	Article
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
ISSN:	0022538X
Last Modified:	25 Oct 2022 09:05
URI:	https://orca.cardiff.ac.uk/id/eprint/57196

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