No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder

Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Ashworth, Lindsay, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Guy, Carol, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, McCandless, Fiona, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2 (4) , pp. 328-331. 10.1034/j.1399-5618.2000.020406.x

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Abstract

OBJECTIVE: A recent case control study has suggested that modest enlargements of a highly polymorphic CAG repeat in exon 1 of the gene encoding potassium channel hKCa3 may be associated with bipolar disorder (BPD). We have examined this hypothesis by genotyping this locus in a family-based association study. METHOD: One hundred and twenty-eight parent offspring trios of British Caucasian origin were examined where the proband was diagnosed with the American Psychiatric Association's Diagnostic and Statistical Manual (DSM)-IV BPD I (n = 123) or II (n = 5). An improved assay was used, with redesigned polymerase chain reaction (PCR) primers, permitting quicker and higher resolution genotyping. The resultant genotypes were analysed using the extended transmission/ disequilibrium test (ETDT). RESULTS: The experimental data did not provide evidence for the preferential transmission of large alleles to bipolar cases (chi2 = 11.12, df = 10, p = 0.349). CONCLUSIONS: Our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to BPD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	bipolar disorder; hKCa3; human potassium channel gene; polymorphic CAG repeat
Publisher:	Wiley-Blackwell
ISSN:	1398-5647
Last Modified:	12 Dec 2022 08:52
URI:	https://orca.cardiff.ac.uk/id/eprint/57822

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