Linkage studies of bipolar disorder with chromosome 18 markers

Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Gill, M., Spurlock, Gillian, Vallada, H. P., Murray, R. M., McGuffin, P., Collier, D. A., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 1999. Linkage studies of bipolar disorder with chromosome 18 markers. American Journal of Medical Genetics 15 (88) , pp. 503-509. 10.1002/(SICI)1096-8628(19991015)88:5<503::AID-AJMG13>3.0.CO;2-U

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Abstract

Evidence consistent with the existence of genetic linkage between bipolar disorder and three regions on chromosome 18, the pericentromeric region, 18q21, and 18q22-q23 have been reported. Some analyses indicated greater evidence for linkage in pedigrees in which paternal transmission of disease occurs. We have undertaken linkage analyses using 12 highly polymorphic markers spanning these three regions of interest in a sample of 48 U.K. bipolar pedigrees. The sample comprises predominantly nuclear families and includes 118 subjects with Diagnostic and Statistical Manual of Mental Disorders (DSM IV) bipolar I disorder and 147 subjects with broadly defined phenotype. Our data do not provide support for linkage using either parametric or nonparametric analyses. Evidence for linkage was not significantly increased by analyses that allowed for heterogeneity nor by analysing the subset of pedigrees consistent with paternal transmission.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Liss
ISSN:	0148-7299
Last Modified:	12 Dec 2022 08:54
URI:	https://orca.cardiff.ac.uk/id/eprint/57939

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