Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging

Meyer, Jan-Philip, Probst, Katrin C. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2014. Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging. Journal of Labelled Compounds and Radiopharmaceuticals 57 (5) , pp. 333-337. 10.1002/jlcr.3197

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Abstract

This review article considers 2′‐labelled and 3′‐labelled nucleosides, which are of great importance as positron emission tomography (PET) probes in clinical diagnostics and PET research. Although the radiochemical preparation of several [18F]‐labelled nucleosides such as [18F]fluorothymidine or [18F](fluoroarabinofuranosyl)cytosine has been accomplished within the last two decades, a number of potentially interesting nucleoside‐based biomarkers are not yet available for automated good manufacturing practice production due to the lack of fast and efficient synthetic methods for late‐stage [18F]‐introduction. In order to meet recent demands for new PET‐based biomarkers in various clinical applications, appropriate precursors that can easily be fluorinated and deprotected need to be developed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	Q Science > QC Physics R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	nucleoside analogues; late stage precursor; [18F]-incorporation; radiosynthesis
Additional Information:	Online publication date: 1 April 2014.
Publisher:	Wiley-Blackwell
ISSN:	0362-4803
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	23 February 2014
Last Modified:	07 Nov 2023 18:02
URI:	https://orca.cardiff.ac.uk/id/eprint/59163

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