Browse by Current Cardiff authors

Almehdi, Ahmed M., Damiati, Samar, Shehadi, Ihsan A., El‐Sadek, Mohamed, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, El‐Kabalawy, Abdalla, Lashine, Yasmina, Nayak, Yogendra, Soliman, Sameh S. M., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Hamdy, Rania 2025. Next-generation Bcl-2 inhibitors: design and evaluation of indolyl-triazole derivatives with anticancer potential. ChemMedChem , e202500265. 10.1002/cmdc.202500265 Item availability restricted.

Giancotti, Gilda, French, Rhiannon, Hayward, Olivia, Lee, Kok Yung, Robinson, Timothy, Ribeiro da Silva, Andreia M., Varnava, Athina, MacFarlane, Marion, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Brancale, Andrea 2025. The discovery of small-molecule inhibitors of cFLIP that sensitise tumour cells to TNF-related apoptosis-inducing ligand. Academia Oncology 2 (2) 10.20935/AcadOnco7680

Scott, Ashleigh T. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2024. Strategies to enhance the racial and ethnic diversity of breast cancer clinical drug trials. Academia Oncology 1 , 2. 10.20935/acadonco7480

Seaton, Gillian, Smith, Hannah, Brancale, Andrea, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Clarkson, Richard ORCID: https://orcid.org/0000-0001-7389-8673 2024. Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age. Molecular Cancer 23 (1) , 7. 10.1186/s12943-023-01922-8

Almehdi, Ahmed M., Soliman, Sameh S. M., El-Shorbagi, Abdel-Nasser A., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Hamdy, Rania 2023. Design, synthesis, and potent anticancer activity of novel indole-based Bcl-2 inhibitors. International Journal of Molecular Sciences 24 (19) , 14656. 10.3390/ijms241914656

Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Zelek, Wioleta, Lippiatt, George, Somerville, Michelle, Burnell, Stephanie, Capitani, Lorenzo, Davies, Kate, Lawton, Helen, Tozer, Thomas, Rees, Tara, Roberts, Kerry, Evans, Mererid, Jackson, Amanda, Young, Charlotte, Fairclough, Lucy, Tighe, Paddy, Wills, Mark, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2022. Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers. Immunology 165 (2) , pp. 250-259. 10.1111/imm.13433

Edwards, Deborah ORCID: https://orcid.org/0000-0003-1885-9297, Csontos, Judit ORCID: https://orcid.org/0000-0003-4597-3052, Pascoe, Michael ORCID: https://orcid.org/0000-0002-7794-8970, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Gillen, Elizabeth ORCID: https://orcid.org/0000-0002-3700-3913, Bennett, Clare ORCID: https://orcid.org/0000-0002-5144-3894, Hannigan, Mark ORCID: https://orcid.org/0000-0002-2512-6721, Carrier, Judith ORCID: https://orcid.org/0000-0002-2657-2280 and Harden, Jane ORCID: https://orcid.org/0000-0001-8158-6450 2022. A rapid scoping review of harm reduction strategies for ecstasy (MDMA) users in recreational settings. [Online]. Research Square: Research Square. Available at: https://doi.org/10.21203/rs.3.rs-2178425/v1

Hamdy, Rania, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, El-Sadek, Mohamed, Hamoda, Alshaimaa M., Shakartalla, Sarra B., AL Shareef, Zainab M., Soliman, Sameh S. M. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. New bioactive fused triazolothiadiazoles as Bcl-2-targeted anticancer agents. International Journal of Molecular Sciences 22 (22) , 12272. 10.3390/ijms222212272

Soukupova, Jitka, Bordoni, Cinzia, Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Yang, William W., Seaton, Gillian, Gruca, Aleksandra, French, Rhiannon, Lee, Kok Yung, Varnava, Athina, Piggott, Luke, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10 (5) , pp. 775-786. 10.1158/1535-7163.MCT-20-0283

Kandil, Sahar B. ORCID: https://orcid.org/0000-0003-1806-9623, Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. Synthesis, biological evaluation and X-ray analysis of bicalutamide sulfoxide analogues for the potential treatment of prostate cancer. Bioorganic and Medicinal Chemistry Letters 36 , 127817. 10.1016/j.bmcl.2021.127817

Kourti, Malamati, Cai, Jun, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. Structural modifications on CORM-3 lead to enhanced anti-angiogenic properties against triple-negative breast cancer cells. Medicinal Chemistry 17 (1) , pp. 40-59. 10.2174/1573406415666191206102452

James, Edward, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Pascoe, Michael ORCID: https://orcid.org/0000-0002-7794-8970 and Smith, Andrew ORCID: https://orcid.org/0000-0001-8805-8028 2021. Online survey into the development of a model legal framework for a cannabis market in the United Kingdom. Drug Science, Policy and Law 7 10.1177/20503245211034931

Kandil, Sahar B. ORCID: https://orcid.org/0000-0003-1806-9623, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2021. Synthesis and biological evaluation of bicalutamide analogues for the potential treatment of prostate cancer. Molecules 26 (1) , 56. 10.3390/molecules26010056

Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., El-Sadek, Mohamed, Lashin, Elsaid, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2020. Design, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2. International Journal of Molecular Sciences 21 (23) , 8980. 10.3390/ijms21238980

Kandil, Sahar B. ORCID: https://orcid.org/0000-0003-1806-9623, Jones, Samuel R., Smith, Sonia, Hiscox, Stephen E. ORCID: https://orcid.org/0000-0003-0105-2702 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2020. Structure-based virtual screening, synthesis and biological evaluation of potential FAK-FAT domain inhibitors for treatment of metastatic cancer. Molecules 25 (15) , 3488. 10.3390/molecules25153488

Cavaliere, Alessandra, Probst, Katrin C., Paisey, Stephen J. ORCID: https://orcid.org/0000-0002-2274-3708, Marshall, Christopher ORCID: https://orcid.org/0000-0002-2228-883X, Dheere, Abdul K. H., Aigbirhio, Franklin, McGuigan, Christopher and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25 (3) , 704. 10.3390/molecules25030704

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Pannecouque, Christophe, Chapman, Fiona M., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2019. Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity. Bioorganic and Medicinal Chemistry Letters 29 (24) , 126721. 10.1016/j.bmcl.2019.126721

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp. 1-14. 10.1016/j.ejmech.2019.07.001

Crusco, Alessandra, Whiteland, Helen, Baptista, Rafael, Forde-Thomas, Josephine E., Beckmann, Manfred, Mur, Luis A. J., Nash, Robert J., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Hoffmann, Karl F. 2019. Antischistosomal properties of sclareol and its heck-coupled derivatives: Design, synthesis, biological evaluation, and untargeted metabolomics. ACS Infectious Diseases 5 (7) , pp. 1188-1199. 10.1021/acsinfecdis.9b00034

Crusco, Alessandra, Baptista, Rafael, Bhowmick, Sumana, Beckmann, Manfred, Mur, Luis A. J., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Hoffmann, Karl F. 2019. The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation. Frontiers in Microbiology 10 , 1444. 10.3389/fmicb.2019.01444

Hamdy, Rania, Elseginy, Samia, Ziedan, Noha, Jones, Arwyn ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2019. New quinoline-based heterocycles as anticancer agents targeting Bcl-2. Molecules 24 (7) , p. 1274. 10.3390/molecules24071274

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Lee, Kok Yung, Davies, Laurie, Rizzo, Sebastiano A., Dart, D. Alwyn and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2019. Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists. European Journal of Medicinal Chemistry 167 , pp. 49-60. 10.1016/j.ejmech.2019.01.054

Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Ritchie, James W. A. 2019. A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology 16 , pp. 185-204. 10.1038/s41571-018-0134-8

James, Edward, Robertshaw, Thomas L and Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236 2019. Emerging from the dark side: new therapeutic applications of scheduled psychoactive substances. Future Medicinal Chemistry 11 (3) 10.4155/fmc-2018-0447

Kourti, Malamati, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Jiang, Wen ORCID: https://orcid.org/0000-0002-3283-1111 and Cai, Jun 2019. Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer. Oncotarget 10 (10) , pp. 1132-1148. 10.18632/oncotarget.26638

Fosu-Mensah, Nelly A. ORCID: https://orcid.org/0000-0003-1872-8529, Jiang, Wen ORCID: https://orcid.org/0000-0002-3283-1111, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Cai, Jun and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2019. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein-protein interaction. Medicinal Chemistry Research 28 (2) , pp. 182-202. 10.1007/s00044-018-2275-9

James, Edward, Robertshaw, Thomas, Chapman, Fiona M., Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Smith, Andrew P. ORCID: https://orcid.org/0000-0001-8805-8028 2019. Using the pharmacy retail model to examine perceptions and biases of a UK population sample towards regulation of specific psychoactive drugs. Drug Science, Policy and Law 5 10.1177/2050324519876123

Shirinzadeh, Hanif, Suzen, Sibel, Altanlar, Nurten and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2018. Antimicrobial activities of new indole derivatives containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide. The Turkish Journal of Pharmaceutical Sciences 15 (3) , pp. 291-297. 10.4274/tjps.55707

Dart, D. Alwyn, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Tommasini-Ghelfi, Serena, Almeida, Gilberto Serrano de, Bevan, Charlotte L., Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2018. Novel trifluoromethylated enobosarm analogues with potent antiandrogenic activity in vitro and tissue selectivity in vivo. Molecular Cancer Therapeutics 17 (9) , pp. 1846-1858. 10.1158/1535-7163.MCT-18-0037

Crusco, Alessandra, Bordoni, Cinzia, Chakroborty, Anand, Whatley, Kezia C.L., Whiteland, Helen, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Hoffmann, Karl F. 2018. Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues. European Journal of Medicinal Chemistry 152 , pp. 87-100. 10.1016/j.ejmech.2018.04.032

James, Edward, Robertshaw, Thomas, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Smith, Andrew ORCID: https://orcid.org/0000-0001-8805-8028 2018. Pharmacies as potential providers of harm reduction services: A preliminary online survey. Drug Science, Policy and Law 4 , pp. 1-14. 10.1177/2050324518767441

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Prencipe, Filippo, Jones, Samuel, Hiscox, Stephen ORCID: https://orcid.org/0000-0003-0105-2702 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2018. The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. Chemical Biology and Drug Design 91 (1) , pp. 314-321. 10.1111/cbdd.13083

Somasagara, R. R., Spencer, S. M., Tripathi, K., Clark, D. W., Mani, C., Madeira da Silva, L., Scalici, J., Kothayer, H., Westwell, A. D. ORCID: https://orcid.org/0000-0002-5166-9236, Rocconi, R. P. and Palle, K. 2017. RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance. Oncogene 36 , pp. 6680-6690. 10.1038/onc.2017.279

Cavaliere, Alessandra, Probst, Katrin, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190 2017. Fluorinated nucleosides as an important class of anticancer and antiviral agents. Future Medicinal Chemistry 9 (15)

Hendriks, Hans R, Govaerts, Anne-Sophie, Fichtner, Iduna, Burtles, Sally, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Peters, Godefridus J 2017. Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative. British Journal of Cancer 117 , pp. 195-202. 10.1038/bjc.2017.167

Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Giancotti, Gilda, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher 2017. Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm 8 (7) , pp. 1414-1420. 10.1039/C7MD00164A

Hamdy, Rania, Ziedan, Noha, Ali, Samina, Bordoni, Cinzia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27 (4) , pp. 1037-1040. 10.1016/j.bmcl.2016.12.061

Ziedan, Noha I, Hamdy, Rania, Cavaliere, Alessandra, Kourti, Malamati, Prencipe, Filippo, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Jones, Arwyn T ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design 10.1111/cbdd.12936

Wymant, Jennifer, Hiscox, Stephen ORCID: https://orcid.org/0000-0003-0105-2702, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Urbe, Sylvie, Clague, Michael and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7 (15) , pp. 2388-2407. 10.7150/jca.15055

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26 (23) , pp. 5618-5623. 10.1016/j.bmcl.2016.10.077

Bassetto, Marcella, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp. 230-243. 10.1016/j.ejmech.2016.04.052

Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15) , pp. 3636-3640. 10.1016/j.bmcl.2016.06.001

Haynes, Brittany, Zhang, Yanhua, Liu, Fangchao, Li, Jing, Petit, Sarah, Kothayer, Hend, Bao, Xun, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Mao, Guangzhao and Shekhar, Malathy P.V. 2016. Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization. Nanomedicine: Nanotechnology, Biology and Medicine 12 (3) , pp. 745-757. 10.1016/j.nano.2015.10.010

Kothayer, Hend, Spencer, Sebastian M., Tripathi, Kaushlendra, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Palle, Komaraiah 2016. Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2030-2034. 10.1016/j.bmcl.2016.02.085

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Wymant, Jennifer, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp. 311-325. 10.1016/j.ejmech.2015.12.037

Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236, ed. 2016. Fluorinated pharmaceuticals: advances in medicinal chemistry. Future Medicine. 10.4155/9781909453968

Shirinzadeh, Hanif, Ince, Elif, Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236, Gurer-Orhan, Hande and Suzen, Sibel 2016. Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities. Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6) , pp. 1312-1321. 10.3109/14756366.2015.1132209

Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2000-2004. 10.1016/j.bmcl.2016.02.088

Edwards, Richard, de Vries, Wilke, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Daniels, Stephen and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2015. Solid-supported iodonium salts for fluorinations. European Journal of Organic Chemistry 2015 (31) , pp. 6909-6916. 10.1002/ejoc.201500992

Cilibrasi, Vincenzo, Tsang, Kwok Ying Ingrid, Morelli, Matteo, Solfa, Francesca, Wiggins, Helen, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20) , pp. 2583-2585. 10.1016/j.tetlet.2015.03.132

Wiggins, Helen L., Wymant, Jennifer M., Solfa, Francesca, Hiscox, Stephen E. ORCID: https://orcid.org/0000-0003-0105-2702, Taylor, Kathryn M. ORCID: https://orcid.org/0000-0002-9576-9490, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93 (3) , pp. 332-342. 10.1016/j.bcp.2014.12.014

Edwards, Richard, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Daniels, Stephen and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015 (3) , pp. 625-630. 10.1002/ejoc.201403378

Fosu-Mensah, Nelly ORCID: https://orcid.org/0000-0003-1872-8529, Peris, María Sánchez, Weeks, Hoi Ping, Cai, Jun and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2015. Advances in small-molecule drug discovery for triple-negative breast cancer. Future Medicinal Chemistry 7 (15) , pp. 2019-2039. 10.4155/fmc.15.129

Meyer, Jan-Philip, Probst, Katrin C., Trist, Iuni Margaret, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2014. A novel radiochemical approach to 1-(2 '-deoxy-2 '-[F-18] fluoro-beta-D-arabinofuranosyl)cytosine (F-18-FAC). Journal of Labelled Compounds and Radiopharmaceuticals 57 (11) , pp. 637-644. 10.1002/jlcr.3233

Velanguparackel, Winnie, Hamon, Nadege, Balzarini, Jan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2014. Synthesis, anti-HIV and cytostatic evaluation of 3′-deoxy-3′-fluorothymidine (FLT) pro-nucleotides. Bioorganic and Medicinal Chemistry Letters 24 (10) , pp. 2240-2243. 10.1016/j.bmcl.2014.03.092

Meyer, Jan-Philip, Probst, Katrin C. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2014. Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging. Journal of Labelled Compounds and Radiopharmaceuticals 57 (5) , pp. 333-337. 10.1002/jlcr.3197

Kothayer, Hend, Elshanawani, Abdalla A., Abu Kull, Mansour E., El-Sabbagh, Osama I., Shekhar, Malathy P. V., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2013. Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Biorganic and Medicinal Chemistry Letters 23 (24) , pp. 6886-6889. 10.1016/j.bmcl.2013.09.087

Sanders, Matthew A., Brahemi, Ghali, Nangia-Makker, Pratima, Balan, Vitaly, Morelli, Matteo, Kothayer, Hend, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Shekhar, Malathy P. V. 2013. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: Design, synthesis, identification, and functional characterization. Molecular Cancer Therapeutics 12 (4) , pp. 373-383. 10.1158/1535-7163.MCT-12-0793

Hamdy, Rania, Ziedan, Noha, Ali, Samia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2013. Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Biorganic and Medicinal Chemistry Letters 23 (8) , pp. 2391-2394. 10.1016/j.bmcl.2013.02.029

Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Hutchings, Alun and Caldicott, D. G. E. 2013. The identification and chemical characterization of a new arylcyclohexylamine, methoxetamine, using a novel Emergency Department toxicosurveillance tool. Drug Testing and Analysis 5 (3) , pp. 203-207. 10.1002/dta.1375

Karaaslan, Cigdem, Kadri, Hachemi, Coban, Tulay, Suzen, Sibel and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2013. Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles. Biorganic and Medicinal Chemistry Letters 23 (9) , pp. 2671-2674. 10.1016/j.bmcl.2013.02.090

Weekes, Ashley Ann, Frydrych, Jan and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2013. Convenient synthesis of substituted 2-phenylbenzothiazoles using solid-supported triphenylphosphine. Synthetic Communications 43 (19) , pp. 2656-2662. 10.1080/00397911.2012.730648

Tekiner-Gulbas, Betul, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Suzen, Sibel 2013. Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer. Current Medicinal Chemistry 20 (36) , pp. 4451-4459. 10.2174/09298673113203690142

Soukupova, J., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673 2012. Inhibitors of Bcl-3 as a novel therapeutic strategy for HER2+ breast cancer. European Journal of Cancer 48 (5) , S225-S225.

Md Tohid, Siti Farah ORCID: https://orcid.org/0000-0002-4772-1062, Ziedan, Noha Ibrahim, Stefanelli, Fabio, Fogli, Stefano and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2012. Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents. European Journal of Medicinal Chemistry 56 , pp. 263-270. 10.1016/j.ejmech.2012.08.009

Cottens, Sylvain, Eaton, Mike, Fuhr, Joseph, Geary, Steward, Johnson, Douglas S., Li, Ge, Raveglia, Luca, Robertson, Graeme M. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2011. Ask the experts: future of the pharmaceutical industry. Future Medicinal Chemistry 3 (15) 10.4155/fmc.11.145

Altug, C., Burnett, Alan Kenneth, Caner, E., Dürüst, Y., Elliott, Mark Christopher ORCID: https://orcid.org/0000-0003-0132-0818, Glanville, Roger P. J., Guy, Carol and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2011. An efficient one-pot multicomponent approach to 5-amino-7-aryl-8-nitrothiazolo[3,2-a]pyridines. Tetrahedron 67 (49) , pp. 9522-9528. 10.1016/j.tet.2011.10.005

Weekes, Ashley Ann, Bagley, Mark Christopher and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2011. An efficient synthetic route to biologically relevant 2-phenylbenzothiazoles substituted on the benzothiazole ring. Tetrahedron 67 (40) , pp. 7743-7747. 10.1016/j.tet.2011.08.004

Ziedan, Noha I., Stefanelli, Fabio, Fogli, Stefano and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2010. Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. European Journal of Medicinal Chemistry 45 (10) , pp. 4523-4530. 10.1016/j.ejmech.2010.07.012

Brahemi, Ghali, Kona, Fathima R., Fiasella, Annal, Buac, Daniela, Soukupova, Jitka, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Burger, Angelika M. and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2010. Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. Journal of Medicinal Chemistry 53 (7) , pp. 2757-2765. 10.1021/jm901757t

Chew, Eng-Hui, Nagle, Amrita A., Zhang, Yaochun, Scarmagnani, Silvia, Palaniappan, Puvithira, Bradshaw, Tracey D., Holmgren, Arne and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2010. Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. Free Radical Biology & Medicine 48 (1) , pp. 98-111. 10.1016/j.freeradbiomed.2009.10.028

Weekes, Ashley Ann, Dix, Matthew C., Bagley, Mark Christopher and Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 2010. Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-Phenylbenzothiazoles. Synthetic Communications 40 (20) , pp. 3027-3032. 10.1080/00397910903353739

Brahemi, Ghali, Burger, A. M., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2010. Homology Modelling of Human E1 Ubiquitin Activating Enzyme. Letters in Drug Design & Discovery 7 (1) , pp. 57-62. 10.2174/157018010789869316

Bruyere, Helene, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2010. Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters 20 (7) , pp. 2200-2203. 10.1016/j.bmcl.2010.02.035

Daniels, Stephen, Md Tohid, Siti Farah ORCID: https://orcid.org/0000-0002-4772-1062, Velanguparackel, Winnie and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2010. The role and future potential of fluorinated biomarkers in positron emission tomography. Expert Opinion on Drug Discovery 5 (3) , pp. 291-304. 10.1517/17460441003652967

Weekes, Ashley Ann and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2009. 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery. Current Medicinal Chemistry 16 (19) , pp. 2430-2440.

Gan, F. F., Chua, Y. S., Scarmagnani, S., Palaniappan, P., Franks, M., Poobalasingam, T., Bradshaw, T. D., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Hagen, T. 2009. Structure-activity analysis of 2 '-modified cinnamaldehyde analogues as potential anticancer agents. Biochemical and Biophysical Research Communications 387 (4) , pp. 741-747. 10.1016/j.bbrc.2009.07.104

Kadri, Hachemi, Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963, Ewan, Kenneth Burnside Ramsay ORCID: https://orcid.org/0000-0001-6622-9009 and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2008. The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain [Poster Presentation/Abstract]. EJC Supplements 6 (12) , p. 137. 10.1016/S1359-6349(08)72370-X

Huber, Kelly, Patel, Poulam, Zhang, Lei, Evans, Helen, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Fischer, Peter M., Chan, Stephen and Martin, Stewart 2008. 2- [(1-methylpropyl)dithio] -1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Molecular Cancer Therapeutics 7 (1) , pp. 143-151. 10.1158/1535-7163.mct-07-0486

Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2008. Advances in Cancer Drug Discovery - A British Association for Cancer Research Meeting. IDrugs 11 (11) , pp. 783-786.

Aiello, Stefania, Wells, Geoffrey, Stone, Erica L., Kadri, Hachemi, Bazzi, Rana, Bell, David R., Stevens, Malcolm F. G., Matthews, Charles S., Bradshaw, Tracey D. and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2008. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). Journal of Medicinal Chemistry 51 (16) , pp. 5135-5139. 10.1021/jm800418z

Brahemi, Ghali, Fiasella, A., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Burger, A. 2008. Design and synthesis of BCA2 inhibitors. EJC Supplements 6 (12) , p. 44.

Callister, M.E., Pinhu, L., Catley, M.C., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Newton, R., Leaver, S.K., Quinlan, G.J., Evans, T.W., Griffiths, M. J. and Burke-Gaffney, A. 2008. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappa B-dependent proinflammatory activation of alveolar epithelial cells. British Journal of Pharmacology 155 (5) , pp. 661-672. 10.1038/bjp.2008.258

Kadri, Hachemi, Matthews, C. S., Bradshaw, T. D., Stevens, M. F. G. and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2008. Synthesis and antitumour evaluation of novel 2-phenylbenzimidazoles. Journal of Enzyme Inhibition and Medicinal Chemistry 23 (5) , pp. 641-647. 10.1080/14756360802205398

White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Brahemi, Ghali 2008. Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Reviews in Molecular Medicine 10 (e8) , pp. 1-14. 10.1017/S1462399408000641

Ziedan, Noha, Kadri, Hachemi and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2008. The development of pro-apoptotic cancer therapeutics. Mini-Reviews in Medicinal Chemistry 8 (7) , pp. 711-718.

Ziedan, Noha, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 and Fogli, S. 2008. Design and synthesis of novel indole derivatives as selective apoptosis-inducers. EJC Supplements 6 (12) , pp. 45-46.

Henriksen, G., Hauser, A. I., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Yousefi, B. H., Schwaiger, M., Drzezga, A. and Wester, H. J. 2007. Metabolically stabilized benzothiazoles for imaging of amyloid plaques. Journal of Medicinal Chemistry 50 (6) , pp. 1087-1089. 10.1021/jm061466g

Matsuura, T., Harrison, R. A., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Nakamura, H., Martynyuk, A. E. and Sumners, C. 2007. Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin. American Journal of Physiology -Cell Physiology 293 (1) , C211-C217. 10.1152/ajpcell.00615.2006

Shah, P. and Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236 2007. The role of fluorine in medicinal chemistry. Journal of Enzyme Inhibition and Medicinal Chemistry 22 (5) , pp. 527-540. 10.1080/14756360701425014

Athanasiou, A., Smith, P. A., Vakilpour, S., Kumaran, N. M., Turner, A. E., Bagiokou, D., Layfield, R., Ray, D. E., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Alexander, S. P. H., Kendall, D. A., Lobo, D. N., Watson, S. A., Lophatanon, A., Muir, K. A., Guo, D. A. and Bates, T. E. 2007. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications 354 (1) , pp. 50-55. 10.1016/j.bbrc.2006.12.179

Athanasiou, A., Clarke, A. B., Turner, A. E., Kumaran, N. M., Vakilpour, S., Smith, P. A., Bagiokou, D., Bradshaw, T. D., Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Fang, L., Lobo, D. N., Constantinescu, C. S., Calabrese, V., Loesch, A., Alexander, S. P. H., Clothier, R. H., Kendall, D. A. and Bates, T. E. 2007. Cannabinoid receptor agonists are mitochondrial inhibitors: A unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and Biophysical Research Communications 364 (1) , pp. 131-137. 10.1016/j.bbrc.2007.09.107

Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236, Mortimer, CG, Wells, G and Crochard, JP 2006. Antitumor benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry 49 (1) , pp. 179-185. 10.1021/jm050942k

Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236, Berry, JM, Bradshaw, TD and Fichtner, I 2005. Quinols as novel therapeutic agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry 48 (2) , pp. 639-644. 10.1021/jm040859h

Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236, Wells, G, Berry, JM and Bradshaw, TD 2003. 4-Substituted-4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. Journal of Medicinal Chemistry 46 (4) , pp. 532-541. 10.1021/jm020984y

Hutchinson, Ian, Chua, Mei-Sze, Browne, Helen L., Trapani, Valentina, Bradshaw, Tracey D., Westwell, Andrew D ORCID: https://orcid.org/0000-0002-5166-9236 and Stevens, Malcolm F. G. 2001. Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles. Journal of Medicinal Chemistry 44 (9) , pp. 1446-1455. 10.1021/jm001104n