Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices

Campbell, Anne, Sumner, Petroc ORCID: https://orcid.org/0000-0002-0536-0510, Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475 and Muthukumaraswamy, Suresh Daniel ORCID: https://orcid.org/0000-0001-7042-3920 2014. Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices. Neuropsychopharmacology -New York- 39 (9) , pp. 2104-2113. 10.1038/npp.2014.58

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Abstract

Alcohol is a rich drug affecting both the γ-amino butyric acid (GABA) and glutamatergic neurotransmitter systems. Recent findings from both modeling and pharmacological manipulation have indicated a link between GABAergic activity and oscillations measured in the gamma frequency range (30–80 Hz), but there are no previous reports of alcohol’s modulation of gamma-band activity measured by magnetoencephalography (MEG) or electroencephalography (EEG). In this single-blind, placebo-controlled crossover study, 16 participants completed two study days, on one day of which they consumed a dose of 0.8 g/kg alcohol, and on the other day a placebo. MEG recordings of brain activity were taken before and after beverage consumption, using visual grating and finger abduction paradigms known to induce gamma-band activity in the visual and motor cortices respectively. Time–frequency analyses of beamformer source reconstructions in the visual cortex showed that alcohol increased peak gamma amplitude and decreased peak frequency. For the motor task, alcohol increased gamma amplitude in the motor cortex. These data support the notion that gamma oscillations are dependent, in part, on the balance between excitation and inhibition. Disruption of this balance by alcohol, by increasing GABAergic inhibition at GABAA receptors and decreasing glutamatergic excitation at N-methyl-D-aspartic acid receptors, alters both the amplitude and frequency of gamma oscillations. The findings provide further insight into the neuropharmacological action of alcohol.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > R Medicine (General)
Publisher:	Nature Publishing Group
ISSN:	0893-133X
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	24 February 2014
Last Modified:	23 Nov 2024 06:45
URI:	https://orca.cardiff.ac.uk/id/eprint/59835

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