MutYH (MYH) and colorectal cancer

Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348, Jones, Sian, Dolwani, Sunil ORCID: https://orcid.org/0000-0002-3113-5472 and Cheadle, Jeremy Peter ORCID: https://orcid.org/0000-0001-9453-8458 2005. MutYH (MYH) and colorectal cancer. Biochemical Society Transactions 33 (4) , pp. 679-683. 10.1042/BST0330679

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Abstract

MAP (MutYH-associated polyposis) is a recently described colorectal adenoma and carcinoma predisposition syndrome that is associated with biallelic-inherited mutations of the human MutY homologue gene, MutYH. MutYH is often also termed MYH. MAP tumours display a mutational signature of somatic guanine-to-thymine transversion mutations in the adenomatous polyposis coli and K-ras genes, reflecting the normal role of MutYH in the base excision repair of adenines misincorporated opposite 7,8-dihydro-8-oxoguanine, a prevalent and stable product of oxidative damage to DNA. However, the full genetic pathway of MAP tumorigenesis has not been elucidated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	adenomatous polyposis coli (APC), colorectal cancer, familial adenomatous polyposis (FAP), MutYH (MYH), MutYH-associated polyposis (MAP)
Publisher:	Portland Press
ISSN:	0300-5127
Last Modified:	25 Oct 2022 09:46
URI:	https://orca.cardiff.ac.uk/id/eprint/59928

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