Browse by Current Cardiff authors

2023. Relationship between 233 colorectal cancer risk loci and survival in 1,926 patients with advanced disease. BJC Reports 1 , 2. 10.1038/s44276-023-00003-z

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy

, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard and Peters, Ulrike 2023. Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nature Genetics 55 , 519–520. 10.1038/s41588-023-01334-w

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martin-Sanchez, Vicente, Moratalla-Navarro, Ferran, Hwan Oh, Jae, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy

, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Bohm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann and Slattery, Martha 2022. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries. Nature Genetics 10.1038/s41588-022-01222-9

Watts, Katie, Wills, Christopher, Madi, Ayman, Palles, Claire, Maughan, Timothy S., Kaplan, Richard, Al-Tassan, Nada A., Kerr, Rachel, Kerr, David J., Houlston, Richard S., Escott-Price, Valentina

2022. Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome. International Journal of Cancer 151 (6) , pp. 957-966. 10.1002/ijc.34046

Wills, Christopher, He, Yazhou, Summers, Matthew G., Lin, Yi, Phipps, Amanda I., Watts, Katie, Law, Philip J., Al-Tassan, Nada A., Maughan, Timothy S., Kaplan, Richard, Houlston, Richard S., Peters, Ulrike, Newcomb, Polly A., Chan, Andrew T., Buchanan, Daniel D., Gallinger, Steve, Marchand, Loic L., Pai, Rish K., Shi, Qian, Alberts, Steven R., Gray, Victoria, West, Hannah D.

, Escott-Price, Valentina

, Dunlop, Malcolm G. and Cheadle, Jeremy

2021. Genome-wide search for determinants of survival in 1,926 patients with advanced colorectal cancer with follow-up in over 22,000 patients. European Journal Of Cancer 159 , pp. 247-258. 10.1016/j.ejca.2021.09.047
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Watts, Katie, Wills, Christopher, Madi, Ayman, Palles, Claire, Maughan, Timothy S., Kaplan, Richard, Al-Tassan, Nada A., Kerr, Rachel, Kerr, David, Gray, Victoria, West, Hannah

, Houlston, Richard S., Escott-Price, Valentina

2021. Genome-wide association studies of toxicity to oxaliplatin and fluoropyrimidine chemotherapy with or without cetuximab in 1800 patients with advanced colorectal cancer. International Journal of Cancer 149 (9) , pp. 1713-1722. 10.1002/ijc.33739

Culliford, Richard, Cornish, Alex J., Law, Philip J., Farrington, Susan M., Palin, Kimmo, Jenkins, Mark A., Casey, Graham, Hoffmeister, Michael, Brenner, Hermann, Chang-Claude, Jenny, Kirac, Iva, Maughan, Tim, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P.

, Aaltonen, Lauri A., Dunlop, Malcom G. and Soulston, Richard S. 2021. Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: A Mendelian randomisation analysis. British Journal of Cancer 124 , pp. 1169-1174. 10.1038/s41416-020-01211-x

Cornish, Alex J., Law, Philip J., Timofeeva, Maria, Palin, Kimmo, Farrington, Susan M., Palles, Claire, Jenkins, Mark A., Casey, Graham, Brenner, Hermann, Chang-Claude, Jenny, Hoffmeister, Michael, Kirac, Iva, Maughan, Tim, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P.

, Aaltonen, Lauri A., Tomlinson, Ian, Dunlop, Malcolm G. and Houlston, Richard S. 2020. Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. Lancet Gastroenterology and Hepatology 5 (1) , pp. 55-62. 10.1016/S2468-1253(19)30294-8

Summers, Matthew G.

, Maughan, Timothy S., Kaplan, Richard, Law, Philip J., Houlston, Richard S., Escott-Price, Valentina

2020. Comprehensive analysis of colorectal cancer-risk loci and survival outcome: a prognostic role for CDH1 variants. European Journal Of Cancer 124 , pp. 56-63. 10.1016/j.ejca.2019.09.024

Gray, Victoria, Briggs, Sarah, Palles, Claire, Jaegar, Emma, Iveson, Timothy, Kerr, Rachel, Saunders, Mark P., Paul, James, Harkin, Andrea, McQueen, John, Summers, Matthew G., Johnstone, Elaine, Wang, Haitao, Gatcombe, Laura, Maughan, Timothy S., Kaplan, Richard, Escott-Price, Valentina

, Al-Tassan, Nada A., Meyer, Brian F., Wakil, Salma M., Houlston, Richard S., Cheadle, Jeremy P.

, Tomlinson, Ian and Church, David N. 2019. Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer. JNCI: Journal of the National Cancer Institute 111 (8) , pp. 828-836. 10.1093/jnci/djy215

Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J., Starr, John, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D., Win, Aung-Ko, Hopper, John, Jenkins, Mark E., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Easton, Douglas F., Pharoah, Paul D. P., Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matošević, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P.

, Aaltonen, Lauri A., Tomlinson, Ian, Houlston, Richard S. and Dunlop, Malcolm G. 2019. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications 10 , 2154. 10.1038/s41467-019-09775-w

West, Hannah

, Coffey, Michelle, Wagner, Michael J., McLeod, Howard L., Colley, James P., Adams, Richard A.

, Fleck, Oliver, Maughan, Timothy S., Fisher, David, Kaplan, Richard S., Harris, Rebecca and Cheadle, Jeremy P.

2018. Role for nucleotide excision repair gene variants in oxaliplatin-induced peripheral neuropathy. JCO Precision Oncology 2 , pp. 1-18. 10.1200/PO.18.00090

Madi, A., Fisher, D., Maughan, T. S., Colley, J. P., Meade, A. M., Maynard, J., Humphreys, V., Wasan, H., Adams, R. A.

, Idziaszczyk, S., Harris, R., Kaplan, R. S. and Cheadle, J. P.

2018. Common and rare DPYD variants are predictive for 5FU/capecitabine (5FU) toxicity: The MRC COIN and COIN-B trials. Presented at: 43rd ESMO Congress 2018, Munich, Germany, 19-23 October 2018. Annals of Oncology. , vol.29 (Supple) Oxford University Press, VIII22. 10.1093/annonc/mdy269.072

Madi, Ayman, Fisher, David, Maughan, Timothy S., Colley, James P., Meade, Angela M., Maynard, Julie, Humphreys, Vikki, Wasan, Harpreet, Adams, Richard A.

, Idziaszczyk, Shelley, Harris, Rebecca, Kaplan, Richard S. and Cheadle, Jeremy P.

2018. Pharmacogenetic analyses of 2,183 patients with advanced colorectal cancer; Potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy. European Journal of Cancer 102 , pp. 31-39. 10.1016/j.ejca.2018.07.009

Tanskanen, Tomas, van den Berg, Linda, Välimäki, Niko, Aavikko, Mervi, Ness-Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Bexe Lindskog, Elinor, Tõnisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hänninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti-Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P.

, Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo and Aaltonen, Lauri A. 2018. Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. International Journal of Cancer 142 (3) , pp. 540-546. 10.1002/ijc.31076

May-Wilson, Sebastian, Sud, Amit, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Fisher, David, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy P.

, Tomlinson, Ian P., Dunlop, Malcolm G. and Houlston, Richard S. 2017. Pro-inflammatory fatty acid profile and colorectal cancer risk: a Mendelian randomisation analysis. European Journal of Cancer 84 , pp. 228-238. 10.1016/j.ejca.2017.07.034

Summers, Matthew

, Smith, Chris, Maughan, Timothy, Kaplan, Rick, Escott-Price, Valentina

2017. BRAF and NRAS locus-specific variants have different outcomes on survival to colorectal cancer. Clinical Cancer Research 23 (11) , pp. 2742-2749. 10.1158/1078-0432.CCR-16-1541

Rodriguez-Broadbent, Henry, Law, Philip J., Sud, Amit, Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Ripatti, Samuli, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy Peter

, Tomlinson, Ian P., Dunlop, Malcolm G. and Houlston, Richard S. 2017. Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. International Journal of Cancer 140 (12) , pp. 2701-2708. 10.1002/ijc.30709

Madi, Ayman, Fisher, David, Maughan, Timothy S., Colley, James P., Meade, Angela M., Tejpar, Sabine, Vam den Bosch, Ben, Maynard, Julie, Humphreys, Vikki, Wasan, Harpreet, Adams, Richard A.

, Idziaszczyk, Shelley, Harris, Rebecca, Kaplan, Richard S. and Cheadle, Jeremy P.

2017. Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab. Journal of Medical Genetics 54 (8) , pp. 567-571. 10.1136/jmedgenet-2016-104317

Seligmann, J.F., Fisher, D., Smith, C. G., Richman, S.D., Elliott, F., Brown, S., Adams, Richard

, Maughan, T., Quirke, P., Cheadle, Jeremy

, Seymour, M. and Middleton, G. 2017. Investigating the poor outcomes of BRAF-mutant advanced colorectal cancer: Analysis from 2530 patients in randomised clinical trials. Annals of Oncology 28 (3) , pp. 562-568. 10.1093/annonc/mdw645

Jarvis, David, Mitchell, Jonathan S., Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Jarvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M., Mimofeeva, Maria N., Meyer, Brian ., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy, Kaplan, Richard, Kerr, Rachel, Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Aaltonen, Lauri A., Cheadle, Jeremy

, Dunlop, Malcolm G., Tomlinson, Ian P. and Houlston, Richard S. 2016. Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer. British Journal of Cancer 115 , pp. 266-272. 10.1038/bjc.2016.188

Orlando, Giulia, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan, Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy Stanley, Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Ko Win, Aung, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Cheadle, Jeremy Peter

, Dunlop, Malcolm G., Tomlinson, Ian P., Aaltonen, Lauri A. and Houlston, Richard S. 2016. Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease. Human Molecular Genetics 25 (11) , pp. 2349-2359. 10.1093/hmg/ddw087

Phipps, Amanda I., Passarelli, Michael N., Chan, Andrew T., Harrison, Tabitha A., Jeon, Jihyoun, Hutter, Carolyn M., Berndt, Sonja I., Brenner, Hermann, Caan, Bette J., Campbell, Peter T., Chang-Claude, Jenny, Chanock, Stephen J., Cheadle, Jeremy Peter

, Curtis, Keith R., Duggan, David, Fisher, David, Fuchs, Charles S., Gala, Manish, Giovannucci, Edward L., Hayes, Richard B., Hoffmeister, Michael, Hsu, Li, Jacobs, Eric J., Jansen, Lina, Kaplan, Richard, Kap, Elisabeth J., Maughan, Timothy S., Potter, John D., Schoen, Robert E., Seminara, Daniela, Slattery, Martha L., West, Hannah, White, Emily, Peters, Ulrike and Newcomb, Polly A. 2016. Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis. Carcinogenesis 37 (1) , pp. 87-95. 10.1093/carcin/bgv161

Cheng, Timothy H. T., Thompson, Deborah, Painter, Jodie, O?Mara, Tracy, Gorman, Maggie, Martin, Lynn, Palles, Claire, Jones, Angela, Buchanan, Daniel D., Ko Win, Aung, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Giles, Graham G, Pharoah, Paul, Peto, Julian, Cox, Angela, Swerdlow, Anthony, Couch, Fergus, Cunningham, Julie M., Goode, Ellen L., Winham, Stacey J., Lambrechts, Diether, Fasching, Peter, Burwinkel, Barbara, Brenner, Hermann, Brauch, Hiltrud, Chang-Claude, Jenny, Salvesen, Helga B., Kristensen, Vessela, Darabi, Hatef, Li, Jingmei, Liu, Tao, Lindblom, Annika, Hall, Per, de Polanco, Magdalena Echeverry, Sans, Monica, Carracedo, Angel, Castellvi-Bel, Sergi, Rojas-Martinez, Augusto, Aguiar Jnr, Samuel, Teixeira, Manuel R., Dunning, Alison M., Dennis, Joe, Otton, Geoffrey, Proietto, Tony, Holliday, Elizabeth, Attia, John, Ashton, Katie, Scott, Rodney J., McEvoy, Mark, Dowdy, Sean C., Fridley, Brooke L., Werner, Henrica M. J., Trovik, Jone, Njolstad, Tormund S., Tham, Emma, Mints, Miriam, Runnebaum, Ingo, Hillemanns, Peter, Dörk, Thilo, Amant, Frederic, Schrauwen, Stefanie, Hein, Alexander, Beckmann, Matthias W., Ekici, Arif, Czene, Kamila, Meindl, Alfons, Bolla, Manjeet K., Michailidou, Kyriaki, Tyrer, Jonathan P., Wang, Qin, Ahmed, Shahana, Healey, Catherine S., Shah, Mitul, Annibali, Daniela, Depreeuw, Jeroen, Al-Tassan, Nada A., Harris, Rebecca, Meyer, Brian F., Whiffin, Nicola, Hosking, Fay J, Kinnersley, Ben, Farrington, Susan M., Timofeeva, Maria, Tenesa, Albert, Campbell, Harry, Haile, Robert W., Hodgson, Shirley, Carvajal-Carmona, Luis, Cheadle, Jeremy Peter

, Easton, Douglas, Dunlop, Malcolm, Houlston, Richard, Spurdle, Amanda and Tomlinson, Ian 2015. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Scientific Reports 5 , 17369. 10.1038/srep17369

Smith, Christopher G., Fisher, David, Harris, Rebecca, Maughan, Timothy S., Phipps, Amanda I., Richman, Susan, Seymour, Matthew, Tomlinson, Ian, Rosmarin, Dan, Kerr, David, Chan, Andrew T., Peters, Ulrike, Newcombe, Polly A., Idziaszczyk, Shelley, West, Hannah, Meade, Angela, Kaplan, Richard and Cheadle, Jeremy P.

2015. Analyses of 7,635 patients with colorectal cancer using independent training and validation cohorts show that rs9929218 in CDH1 is a prognostic marker of survival. Clinical Cancer Research 21 (15) , pp. 3453-3461. 10.1158/1078-0432.CCR-14-3136

Al-Tassan, Nada A., Whiffin, Nicola, Hosking, Fay J., Palles, Claire, Farrington, Susan M., Dobbins, Sara E., Harris, Rebecca, Gorman, Maggie, Tenesa, Albert, Meyer, Brian F., Wakil, Salma M., Kinnersley, Ben, Campbell, Harry, Martin, Lynn, Smith, Christopher G., Idziaszczyk, Shelley Alexis, Barclay, Ella, Maughan, Timothy Stanley, Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchannan, Daniel D., Ko Win, Aung, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Dunlop, Malcolm G., Tomlinson, Ian P., Cheadle, Jeremy Peter

and Houlston, Richard S. 2015. A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Scientific Reports 5 , 10442. 10.1038/srep10442

Venderbosch, Sabine, Nagtegaal, Iris D., Maughan, Tim S., Smith, Christopher G., Cheadle, Jeremy P.

, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T., Richman, Susan D., Meijer, Gerrit A., Ylstra, Bauke, Heideman, Danielle A. M., de Haan, Anton F. J., Punt, Cornelius J. A. and Koopman, Miriam 2014. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clinical Cancer Research 20 (20) , pp. 5322-5330. 10.1158/1078-0432.CCR-14-0332

Smith, Christopher G., West, Hannah, Harris, Rebecca, Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Richman, Susan, Quirke, Philip, Seymour, Matthew, Escott-Price, Valentina

, Steinke, Verena, Propping, Peter, Hes, Frederik J., Wijnen, Juul and Cheadle, Jeremy

2014. Response. Journal of the National Cancer Institute 106 (5) , dju087. 10.1093/jnci/dju087

Smith, Chris, Fisher, D., Claes, B., Maughan, T. S., Idziaszczyk, Shelley, Peuteman, G., Harris, Rebecca, James, Michelle D., Meade, A., Jasani, Bharat, Adams, Richard A.

, Kenny, S., Kaplan, R., Lambrechts, D. and Cheadle, Jeremy P.

2013. Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab. Clinical Cancer Research 19 (15) , pp. 4104-4113. 10.1158/1078-0432.CCR-12-2581

Smith, Chris, West, Hannah, Harris, Rebecca, Idziaszczyk, Shelley Alexis, Maughan, Timothy Stanley, Kaplan, Richard, Richman, Susan, Quirke, Philip, Seymour, Matthew, Escott-Price, Valentina

, Steinke, Verena, Propping, Peter, Hes, Frederik J., Wijnen, Juul and Cheadle, Jeremy P.

2013. Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis. Journal of the National Cancer Institute 105 (16) , pp. 1249-1253. 10.1093/jnci/djt183

Smith, Chris, Naven, Marc

, Harris, Rebecca, Colley, James, West, Hannah, Li, Ning, Liu, Yuan, Adams, Richard

, Maughan, Timothy S., Nichols, Laura, Kaplan, Richard, Wagner, Michael J., McLeod, Howard L. and Cheadle, Jeremy P.

2013. Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer. Human Mutation 34 (7) , pp. 1026-1034. 10.1002/humu.22333

Dunlop, Malcolm G., Dobbins, Sara E., Farrington, Susan Mary, Jones, Angela M., Palles, Claire, Whiffin, Nicola, Tenesa, Albert, Spain, Sarah, Broderick, Peter, Ooi, Li-Yin, Domingo, Enric, Smillie, Claire, Henrion, Marc, Frampton, Matthew, Martin, Lynn, Grimes, Graeme, Gorman, Maggie, Semple, Colin, Ma, Yusanne P., Barclay, Ella, Prendergast, James, Cazier, Jean-Baptiste, Olver, Bianca, Penegar, Steven, Lubbe, Steven, Chander, Ian, Carvajal-Carmona, Luis G., Ballereau, Stephane, Lloyd, Amy, Vijayakrishnan, Jayaram, Zgaga, Lina, Rudan, Igor, Theodoratou, Evropi, Thomas, Huw, Maher, Eamonn, Evans, Gareth, Walker, Lisa, Halliday, Dorothy, Lucassen, Anneke, Paterson, Joan, Hodgson, Shirley, Homfray, Tessa, Side, Lucy, Izatt, Louise, Donaldson, Alan, Tomkins, Susan, Morrison, Patrick, Brewer, Carole, Henderson, Alex, Davidson, Rosemarie, Murday, Victoria, Cook, Jaqueline, Haites, Neva, Bishop, Timothy, Sheridan, Eamonn, Green, Andrew, Marks, Christopher, Carpenter, Sue, Broughton, Mary, Greenhalge, Lynn, Suri, Mohnish, Starr, John M., Deary, Ian, Kirac, Iva, Kovacevi, Dujo, Aaltonen, Lauri A., Renkonen-Sinisalo, Laura, Mecklin, Jukka-Pekka, Matsuda, Koichi, Nakamura, Yusuke, Okada, Yukinori, Gallinger, Steven, Duggan, David J., Conti, David, Newcomb, Polly, Hopper, John, Jenkins, Mark A., Schumacher, Fredrick, Casey, Graham, Easton, Douglas, Shah, Mitul, Pharoah, Paul, Lindblom, Annika, Liu, Tao, Edler, David, Lenander, Claes, Dalén, Johan, Hjern, Fredrik, Lundqvist, Nils, Lindforss, Ulrik, Påhlman, Lars, Smedh, Kennet, Törnqvist, Anders, Holm, Jörn, Janson, Martin, Andersson, Magnus, Ekelund, Susanne, Olsson, Louise, Smith, Chris, West, Hannah, Cheadle, Jeremy Peter

, MacDonald, Graham, Samuel, Leslie M., Ahmad, Athar, Corrie, Philippa, Jodrell, Duncan, Palmer, Cheryl, Wilson, Charles, O'Hagan, Julie, Smith, David, McDermott, Ray, Walshe, Janice, Cassidy, James, McDonald, Alec, Mohammed, Nazia, White, Jeff, Yosef, Hosney, Breathnach, Oscar, Grogan, Liam, Thomas, Robert, Eatock, Martin, Henry, Paul, Houston, Russell, Johnston, Patrick, Wilson, Richard, Geh, Ian, Danwata, Falalu, Hindley, Andrew, Susnerwala, Shabbir, Bradley, Chris, Conn, Andrew, Raine, Anne, Twelves, Chris, Falk, Stephen, Hopkins, Kirstin, Tahir, Saad, Dhadda, Amandeep, Maraveyas, Anthony, Sgouros, Joseph, Teo, Mark, Ahmad, Rizvana, Cleator, Susan, Creak, Antonia, Lowdell, Charles, Riddle, Philippa, Benstead, Kim, Farrugia, David, Reed, Nicholas, Shepherd, Stephen, Levine, Edward, Mullamitha, Saifee, Saunders, Mark, Valle, Juan, Wilson, Gregory, Jones, Adam, Weaver, Andrew, Clark, Peter I., Haylock, Brain, Iqbal, Mussawar I., Myint, Arthur S., Smith, David, Beesley, Sharon, Sevitt, Timothy, Nicoll, Jonathan, Daniel, Francis, Ford, Victoria, Talbot, Toby, Butt, Mohammad, Hamid, Abdel, Mack, Paul, Roy, Raj, Osborne, Richard, McKinna, Fiona, Alsab, Heidar, Basu, Devyanee, Murray, Phillip, Sizer, Bruce, Azam, Faisal A., Neupane, Rekha, Waterston, Ashita, Glaholm, John, Blesing, Claire, Lowndes, Sarah, Medisetti, Aruna, Gaya, Andrew, Leslie, Martin, Maisey, Nicholas, Ross, Paul, Dunn, Grainne, Al-Salihi, Omar, Wasan, Harpreet S., Palmer, Cheryl, Tan, Li Tee, Dent, Jo, Hofmann, Uschi, Joffe, Johnathan K., Sherwin, Elizabeth, Soomal, Rabinder, Chakrabarti, Amitabha, Joseph, Shibu, Van der Voet, Johannes, Wadd, Nicholas J., Wilson, David, Anjarwalia, Salim, Hall, Julia, Hughes, Rob, Polychronis, Andrew, Scarffe, John H., Hill, Mark, James, Rodger D., Shah, Riyaz, Summers, Jeffrey, Hartley, Andrew, Carney, Desmond, McCaffrey, John, Bystricky, Brano, O'Reilly, Seamus, Gupta, Rajnish, Al-Mishlab, Talib, Gidden, Fiona, O'Hara, Richard, Stewart, Jill, Ashford, Richard, Glynne-Jones, Robert, Harrison, Mark, Mawdsley, Suzannah, Barlow, Hilary, Tighe, Mary, Walther, Julie, Neal, Janet, Rees, Charlotte, Bridgewater, John, Karp, Stephen, McGovern, Ursula, Atherton, Philip J., El-deeb, Hany, Macmillan, Craig, Patel, Kinnari, Bessell, Eric Michael, Dickinson, Peter D., Potter, Vanessa, Jephcott, Catherine, McAdam, Karen, Wrigley, Jessica, Osborne, Richard, Muthuramalingam, Sethupathi, O'Callaghan, Anne, Bridgewater, John, Melcher, Lucinda, Braconi, Chiara, Geh, Ju Ian, Palmer, Dan, Narayana, Priya, Steven, Neil, Gaya, Andres, Maisey, Nicholas, Rudman, Sarah, Chakraborti, Prabir, Kelly, Kay, Macgregor, Carol, Whillis, David, Freebairn, Alice, Gildersleve, James, Sharif, Sahid, Astras, George, Hickish, Tamas, Beech, Darren, Ellis, Richard, Kulkarni, Rajendra, Shankland, K., Begent, Richard, Mayer, Astrid, Meyer, Timothy, Strauss, Sandra, Hall, Viriginia, Raj, Sanjay, Chau, Ian, Cunningham, David, Birtle, Alison, Biswas, Ashoke, Susnerwala, Shabbir, Wise, Marcus, Cummins, Sebastian, Essapen, Sharadah, Middleton, Gary, Topham, Claire, Langley, Ruth, McKinna, Fiona, Webb, Andrew, Wilkins, Marie, Iveson, Timothy John, Dhadda, Amandeep, Hamid, Abdel, Askill, Colin, Wagstaff, John, Azzabi, Ashraf, Bateman, Adrian, Prejbisz, Jan, Tsang, David, Ali, Nasim, Jones, Amanda, O'Neill, Paul, Cottrill, Christopher, Propper, David, Lofts, Fiona Jane, Kennedy, James, Anthoney, David A., Cooper, Rachel, Crellin, Adrian, Melcher, Alan, Seymour, Matthew, Baughan, Christopher, Alexander, Emma, Cleator, Susan, Crown, John, Fennelly, David, Adab, Fawzi, Giridharan, Selvaraj, Pedley, Ian, Wright, Kathryn, Bliss, Peter, Cogill, Geoffrey, Lo, Nangi, Toy, Elizabeth, Bridgewater, John, Hochhauser, Daniel, Ledermann, Jonathan, Brewster, A. E., Maughan, Timothy Stanley, Mort, Diana, Mukherjee, Somnath, Dobrowsky, Werner, Calvert, Paula, Leonard, Gregory, Ahmad, Rizvana, Ford, Hugo, Moody, Anne Margeret, Goriah, Sonia, Wilkins, Margeret, Clive, Sally, Dawson, Lesley, McLean, Catriona, Phillips, Hamish Andrew, Gopi, Kakumudi, Tomlinson, Marjorie, Clenton, Susan, Furniss, Debra, Hornbuckle, Joanne, Pledge, Simon, Wadsley, Jonathan, Abbas, Mohammed, Marshall, Ernest, Harper-Wynne, Catherine, Barnes, Anne, Kumar, Satish, Vigneswaran, Vallipuram, Farrugia, David, Webb, Andrew, Gollins, Simon, Falk, Stephen, Genton, M., Sparrow, Geoff, Bale, Catherine, Fuller, C., Mullard, Anna, Stuart, Nicholas, Williams, Rachel, Keane, Maccon, Maughan, Tim, Seymour, Matthew, Wilson, Richard, Wasan, Harpreet, Adams, Richard Alexander

, Madi, Ayman, Cassidy, James, Kennedy, James, Hodgkinson, Elizabeth, Rogers, Penny, Pope, Malcolm, Kaplan, Rick, Meade, Angela, Parmar, Mahesh, Kenny, Sarah, Fisher, David, Harper, Lynda, Mitchell, Jena, Nichols, Laura, Sydes, Benjamin, Clement, Louise, Kay, Edward, Courtney, Cheryl, Gallagher, Madalena, Murphy, Claire, Thompson, Lindsay, Beall, Sarah, Hassan, Sharma, Gracie, Richard, Griffiths, Gareth O., Mason, Malcolm David

, Parker, Chris, Rudd, Robin, Johnson, Patrick, Whelan, Jeremy, Northover, John, Brown, Julia, Aapro, Matti, Stout, Ronald, Midgley, Rachel, Kerr, David J., Campbell, Harry, Tomlinson, Ian P. and Houlston, Richard S. 2012. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk [Letter]. Nature Genetics 44 (7) , pp. 770-776. 10.1038/ng.2293

Houlston, Richard S., Cheadle, Jeremy Peter

and Maughan, Timothy Stanley 2012. COGENT (COlorectal cancer GENeTics) revisited. Mutagenesis 27 (2) , pp. 143-151. 10.1093/mutage/ger059

Maughan, Timothyn S., Adams, Richard A.

, Smith, Chris, Meade, Angela M., Seymour, Matthew T., Wilson, Richard H., Idziaszczyk, Shelley A., Harris, Rebecca, Fisher, David, Kenny, Sarah L., Kay, Edward, Mitchell, Jenna K., Madi, Ayman, Jasani, Bharat, James, Michelle D., Bridgewater, John, Kennedy, M. John, Claes, Bart, Lambrechts, Diether, Kaplan, Richard and Cheadle, Jeremy P.

2011. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. The Lancet 377 (9783) , pp. 2103-2114. 10.1016/S0140-6736(11)60613-2

Spain, Sarah L., Carvajal-Carmona, Luis G., Howarth, Kimberley M., Jones, Angela M., Su, Zhan, Cazier, Jean-Baptiste, Williams, Jennet, Aaltonen, Lauri A., Pharoah, Paul, Kerr, David J., Cheadle, Jeremy Peter

, Li, Li, Casey, Graham, Vodicka, Pavel, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Morreau, Hans, van Wezel, Tom, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellvi-Bel, Sergi, Dunlop, Malcolm, Houlston, Richard S. and Tomlinson, Ian P. M. 2011. Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13. Human Molecular Genetics 21 (4) , pp. 934-946. 10.1093/hmg/ddr523

Tomlinson, Ian P. M., Carvajal-Carmona, Luis G., Dobbins, Sara E., Tenesa, Albert, Jones, Angela M., Howarth, Kimberley, Palles, Claire, Broderick, Peter, Jaeger, Emma E. M., Farrington, Susan, Lewis, Annabelle, Prendergast, James G. D., Pittman, Alan M., Theodoratou, Evropi, Olver, Bianca, Walker, Marion, Penegar, Steven, Barclay, Ella, Whiffin, Nicola, Martin, Lynn, Ballereau, Stephane, Lloyd, Amy, Gorman, Maggie, Lubbe, Steven, Howie, Bryan, Marchini, Jonathan, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Castells, Antoni, Carracedo, Angel, Castellvi-Bel, Sergi, Duggan, David, Conti, David, Cazier, Jean-Baptiste, Campbell, Harry, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Gallinger, Steven, Newcomb, Polly, Hopper, John, Jenkins, Mark A., Aaltonen, Lauri A., Kerr, David J., Cheadle, Jeremy Peter

, Pharoah, Paul, Casey, Graham, Houlston, Richard S. and Dunlop, Malcolm G. 2011. Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genetics 7 (6) , e1002105. 10.1371/journal.pgen.1002105

Houlston, Richard S, Cheadle, Jeremy Peter

, Dobbins, Sara E., Tenesa, Albert, Jones, Angela M., Howarth, Kimberley, Spain, Sarah L., Broderick, Peter, Domingo, Enric, Farrington, Susan, Prendergast, James G. D., Pittman, Alan M., Theodoratou, Evi, Smith, Chris, Olver, Bianca, Walther, Axel, Barnetson, Rebecca A., Churchman, Michael, Jaeger, Emma E. M., Penegar, Steven, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Mager, Rachel, Johnstone, Elaine, Midgley, Rachel, Niittymäki, Iina, Tuupanen, Sari, Colley, James, Idziaszczyk, Shelley Alexis, Thomas, Huw J. W., Lucassen, Anneke M., Evans, D. Gareth R., Maher, Eamonn R., Maughan, Timothy Stanley, Dimas, Antigone, Dermitzakis, Emmanouil, Cazier, Jean-Baptiste, Aaltonen, Lauri A., Pharoah, Paul, Kerr, David J., Carvajal-Carmona, Luis G., Campbell, Harry, Dunlop, Malcolm G. and Tomlinson, Ian P. M. 2010. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 [Letter]. Nature Genetics 42 (11) , pp. 973-977. 10.1038/ng.670

Idziaszczyk, Shelley Alexis, Wilson, C. H., Smith, Chris, Adams, D. J. and Cheadle, Jeremy Peter

2010. Analysis of the frequency of GNAS codon 201 mutations in advanced colorectal cancer [Letter]. Cancer Genetics and Cytogenetics 202 (1) , pp. 67-69. 10.1016/j.cancergencyto.2010.04.023

Cheadle, Jeremy Peter

2010. MUTYH-associated polyposis. Rodriguez-Bigas, Miguel A., Cutait, Raul, Lynch, Patrick M., Tomlinson, Ian and Vasen, Hans F. A., eds. Hereditary Colorectal Cancer, M.D. Anderson Solid Tumor Oncology Series, vol. 5. New York: Springer, pp. 133-146.

Dallosso, Anthony Richard, Jones, Siân, Azzopardi, Duncan, Escott-Price, Valentina

, Al-Tassan, Nada A., Williams, Geraint Trefor

, Idziaszczyk, Shelley Alexis, Davies, D. Rhodri, Milewski, Peter, Williams, Sally, Beynon, John, Sampson, Julian Roy

2009. The APC Variant p.Glu1317Gln predisposes to colorectal adenomas by a novel mechanism of relaxing the target for tumorigenic somatic APC mutations. Human Mutation 30 (10) , pp. 1412-1418. 10.1002/humu.21089

Bonnet, Cleo, Aldred, Mark, Von Ruhland, Christopher John, Harris, Rebecca, Sandford, Richard and Cheadle, Jeremy Peter

2009. Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis. Human Molecular Genetics 18 (12) , pp. 2166-2176. 10.1093/hmg/ddp149

Cheadle, Jeremy Peter

2009. MUTYH-associated colorectal polyposis and cancer. Schwab, Manfred, ed. Encyclopedia of Cancer. 2nd ed, Springer,

Tee, Andrew

2009. Tuberous sclerosis complex. Schwab, Manfred, ed. Encyclopedia of Cancer. 2nd ed, Springer,

University of Wales 2008. Screening methods and sequences relating thereto. US7393940B2. [Patent].

Azzopardi, Duncan, Dallosso, Anthony Richard, Eliason, Kristilyn, Hendrickson, Brant C., Jones, Natalie, Rawstorne, Edward Charles, Colley, James, Escott-Price, Valentina

, Frye, Cynthia, Sampson, Julian Roy

, Wenstrup, Richard, Scholl, Thomas and Cheadle, Jeremy Peter

2008. Multiple rare nonsynonymous variants in the 'adenomatous polyposis coli' gene predispose to colorectal adenomas. Cancer Research 68 (2) , pp. 358-363. 10.1158/0008-5472.CAN-07-5733

Dallosso, Anthony Richard, Dolwani, Sunil

, Jones, N., Jones, Sian, Colley, James, Maynard, Julie Helen, Idziaszczyk, Shelley Alexis, Humphreys, Vikki, Arnold, J., Donaldson, A., Eccles, D., Ellis, A., Evans, D. G., Frayling, Ian, Hes, F. J., Houlston, R S, Maher, E R, Nielsen, M, Parry, S, Tyler, E, Escott-Price, Valentina

, Cheadle, Jeremy Peter

2008. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. Gut 57 (9) , pp. 1252-1255. 10.1136/gut.2007.145748

Payne, Y., Williams, M., Cheadle, Jeremy Peter

, Stott, N. C. H., Rowlands, M., Shickle, D., West, G., Meredith, Linda, Goodchild, M., Harper, Peter Stanley and Clarke, Angus John

2008. Carrier screening for cystic fibrosis in primary care: evaluation of a project in South Wales The South Wales Cystic Fibrosis Carrier Screening Research Team. Clinical Genetics 51 (3) , pp. 153-163. 10.1111/j.1399-0004.1997.tb02445.x

Goorden, Susanna M. I., van Woerden, Geeske M., van der Weerd, Louise, Cheadle, Jeremy Peter

and Elgersma, Ype 2007. Cognitive deficits inTsc1+/-mice in the absence of cerebral lesions and seizures. Annals of Neurology 62 (6) , pp. 648-655. 10.1002/ana.21317

Cheadle, Jeremy Peter

2007. MUTYH-associated polyposis - From defect in base excision repair to clinical genetic testing. DNA Repair 6 (3) , pp. 274-279. 10.1016/j.dnarep.2006.11.001

Dolwani, Sunil

, Williams, Geraint Trefor

, West, K.P., Newman, J., Stock, D., Williams, A.P., Best, J., Cheadle, Jeremy Peter

2007. Analysis of inherited MYH (MUTYH) mutations in British Asian patients with colorectal cancer [Letter]. Gut 56 (4) , p. 593. 10.1136/gut.2006.094532

Wilson, Catherine Helen, Bonnet, Cleo, Guy, Carol, Idziaszczyk, Shelley Alexis, Colley, James, Humphreys, Vikki, Maynard, Julie Helen, Sampson, Julian Roy

2006. Tsc1 Haploinsufficiency without Mammalian Target of Rapamycin Activation Is Sufficient for Renal Cyst Formation in Tsc1+/- Mice. Cancer Research 66 (16) , pp. 7934-8. 10.1158/0008-5472.CAN-06-1740

Wilson, Catherine Helen, Idziaszczyk, Shelley Alexis, Colley, James, Humphreys, Vikki, Guy, Carol, Maynard, Julie Helen, Sampson, Julian Roy

2005. Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background. Cancer Research 65 (22) , pp. 10179-10182. 10.1158/0008-5472.CAN-05-2688

Colley, James, Jones, Sian, Dallosso, Anthony R., Maynard, Julie Helen, Humphreys, Vikki, Dolwani, Sunil

2005. Rapid recognition of aberrant dHPLC elution profiles using the Transgenomic NavigatorTM software. Human Mutation 26 (2) , p. 165. 10.1002/humu.9354

Wilson, Catherine Helen, Idziaszczyk, Shelley Alexis, Parry, Lee

, Guy, Carol, Griffiths, David Francis Rees, Lazda, Edgar Janis, Bayne, Rosemary A. L., Smith, Andrew J. H., Sampson, Julian Roy

2005. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human Molecular Genetics 14 (13) , pp. 1839-1850. 10.1093/hmg/ddi190

Sampson, Julian Roy

, Jones, Sian, Dolwani, Sunil

2005. MutYH (MYH) and colorectal cancer. Biochemical Society Transactions 33 (4) , pp. 679-683. 10.1042/BST0330679

Bai, Haibo, Jones, Sian, Guan, Xin, Wilson, Teresa M., Sampson, Julian Roy

, Cheadle, Jeremy Peter

and Lu, A-Lien 2005. Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis. Nucleic Acids Research 33 (2) , pp. 597-604. 10.1093/nar/gki209

Fleischmann, Christina, Peto, Julian, Cheadle, Jeremy Peter

, Shah, Bindiya, Sampson, Julian Roy

and Houlston, Richard S. 2004. Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer. International Journal of Cancer 109 (4) , pp. 554-558. 10.1002/ijc.20020

Jones, Sian, Lambert, S., Williams, Geraint Trevor

, Best, J. M., Sampson, Julian Roy

2004. Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas. British Journal of Cancer 90 (8) , pp. 1591-1593. 10.1038/sj.bjc.6601747

Al-Tassan, Nada, Eisen, Tim, Maynard, Julie Helen, Bridle, Helen, Shah, Bindiya, Fleischmann, Christina, Sampson, Julian Roy

, Cheadle, Jeremy Peter

and Houlston, Richard S. 2004. Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma. Human Genetics 114 (2) , pp. 207-210. 10.1007/s00439-003-1033-2

Kwiatkowski, D.J., Reeve, M. P., Cheadle, Jeremy Peter

2003. Molecular genetics. Curatolo, Paolo, ed. Tuberous Sclerosis Complex: From Basic Science to Clinical Phenotypes, International Review of Child Neurology (Mac Keith Press), Cambridge: Cambridge University Press, pp. 228-263.

Cheadle, Jeremy Peter

2003. Exposing the MYtH about base excision repair and human inherited disease. Human Molecular Genetics 12 (s2) , R159-R165. 10.1093/hmg/ddg259

Sampson, Julian Roy

, Dolwani, Sunil

, Jones, Sian, Eccles, Diana, Ellis, Anthony, Evans, D. Gareth, Frayling, Ian Martin, Jordan, Sheila, Maher, Eamonn R., Mak, Tony, Maynard, Julie Helen, Pigatto, Francesca, Shaw, Joan and Cheadle, Jeremy Peter

2003. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. The Lancet 362 (9377) , pp. 39-41. 10.1016/S0140-6736(03)13805-6

Gill, Hefin, Cheadle, Jeremy Peter

, Maynard, Julie Helen, Fleming, Nick, Whatley, Sharon D., Cranston, T, Thompson, E M, Leonard, H, Davis, M, Christodoulou, J, Skjeldal, O, Hanefeld, F, Kerr, A, Tandy, A, Ravine, D. and Clarke, Angus John

2003. Mutation analysis in the MECP2 gene and genetic counselling for Rett syndrome. Journal of Medical Genetics 40 (5) , pp. 380-384. 10.1136/jmg.40.5.380

Cheadle, Jeremy Peter

, Dolwani, Sunil

2003. Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma [Letter]. Carcinogenesis 24 (7) , pp. 1281-1282. 10.1093/carcin/bgg068

Emmerson, Paul, Maynard, Julie Helen, Jones, Sian, Butler, Rachel, Sampson, Julian Roy

2003. Characterizing mutations in samples with low-level mosaicism by collection and analysis of DHPLC fractionated heteroduplexes. Human Mutation 21 (2) , pp. 112-115. 10.1002/humu.10159

Cheadle, Jeremy Peter

and Sampson, J. 2003. Tuberous sclerosis: genetics. Cooper, David Neil, ed. Encyclopedia of the Human Genome, London: Nature Publishing Group, pp. 650-656.

Jones, Sian, Emmerson, Paul, Maynard, Julie Helen, Best, Jacqueline M., Jordan, Sheila, Williams, Geraint Trefor

2002. Biallelic germline mutations in MYH predispose to multiple colorectal ademona and somatic G:C to T:A mutations. Human Molecular Genetics 11 (23) , pp. 2961-2967. 10.1093/hmg/11.23.2961

Al-Tassan, Nada

, Chmiel, Nikolas H., Maynard, Julie Helen, Fleming, Nick, Livingston, Alison L., Williams, Geraint Trefor

, Hodges, Angela Kaye, Davies, D.Rhodri, David, Sheila S., Sampson, Julian Roy

2002. Inherited variants of MYH associated with somatic G:C to T:A mutations in colorectal tumors. Nature Genetics 30 (2) , pp. 227-32. 10.1038/ng828

Cheadle, Jeremy Peter

, Krawczak, Michael, Thomas, Meinir W, Hodges, Angela Kaye, Al-Tassan, Nada, Fleming, Nick and Sampson, Julian Roy

2002. Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours. Cancer Research 62 , pp. 363-366.

Cheadle, Jeremy Peter

, Krawczak, Michael, Thomas, Meinir W., Hodges, Angela Kaye, Al-Tassan, Nada, Fleming, Nick and Sampson, Julian Roy

2002. Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours. Cancer Research 62 (2) , pp. 363-366.

Antonarakis, Emmanuel S., Sampson, Julian Roy

2002. Temperature modulation of DHPLC analysis for detection of coexisting constitutional and mosaic sequence variants in TSC2. Journal of Biochemical and Biophysical Methods 51 (2) , pp. 161-164. 10.1016/S0165-022X(02)00011-8

Hodges, Angela K., Li, Shaowei, Maynard, Julie Helen, Parry, Lee

, Braverman, Richard, DeClue, Jeffrey E., Cheadle, Jeremy Peter

2001. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Human Molecular Genetics 10 (25) , pp. 2899-9205. 10.1093/hmg/10.25.2899

Parry, Lee

, Maynard, Julie Helen, Patel, A., Clifford, S. C., Morrissey, C., Maher, E. R., Cheadle, Jeremy Peter

2001. Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. British Journal of Cancer 85 , pp. 1226-1230. 10.1054/bjoc.2001.2072

Soucek, Thomas, Rosner, Margit, Miloloza, Angelina, Kubista, Marion, Cheadle, Jeremy Peter

and Hengstschläger, Markus 2001. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene 20 (35) , pp. 4904-4909.

Jones, Alistair C., Sampson, Julian Roy

2001. Low level mosaicism detectable by DHPLC but not by direct sequencing. Human Mutation 17 (3) , pp. 233-234. 10.1002/humu.8

Fleming, Nick, Maynard, Julie H., Tzitzis, Loukas, Sampson, Julian Roy

2001. LD-PCR coupled to long-read direct sequencing: an approach for mutation detection in genes with compact genomic structures. Journal of Biochemical and Biophysical Methods 47 (1-2) , pp. 131-136. 10.1016/S0165-022X(00)00159-7

Benvenuto, Giovanna, Li, Shaowei, Brown, Samantha J., Braverman, Richard, Vass, William C., Cheadle, Jeremy Peter

, Halley, Dicky J. J., Sampson, Julian Roy

, Wienecke, Ralf and DeClue, Jeffrey E. 2000. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19 (54) , pp. 6306-6316. 10.1038/sj.onc.1204009

Cheadle, Jeremy Peter

, Dobbie, Lorraine, Idziaszczyk, Shelley, Hodges, Angela Kaye, Smith, Andrew J.H., Sampson, Julian Roy

and Young, Janet 2000. Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus. Mammalian Genome 11 (12) , pp. 1135-1138. 10.1007/s003350010203

Lamlum, Hanan, Al-Tassan, Nada A., Jaeger, Emma, Frayling, Ian Martin, Sieber, Oliver, Bin Reza, Faisal, Eckert, Maria, Rowan, Andrew, Barclay, Ella, Atkin, Wendy, Williams, Christopher, Gilbert, John, Cheadle, Jeremy Peter

, Bell, Jennie, Houlston, Richard, Bodmer, Walter, Sampson, Julian Roy

and Tomlinson, Ian 2000. Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q. Human Molecular Genetics 9 (15) , pp. 2215-2221.

Cheadle, Jeremy Peter

, Reeve, Mary Pat, Sampson, Julian Roy

and Kwiatkowski, David J. 2000. Molecular genetic advances in tuberous sclerosis. Human Genetics 107 (2) , pp. 97-114. 10.1007/s004390000348

Jones, Alistair C., Sampson, Julian Roy

, Hoogendoorn, Bastiaan

, Cohen, David and Cheadle, Jeremy Peter

2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106 (6) , pp. 663-668. 10.1007/s004390000316

Parry, Lee

, Maynard, Julie Helen, Patel, Amit, Hodges, Angela, von Deimling, Andreas, Sampson, Julian Roy

2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Human Genetics 107 (4) , pp. 350-356. 10.1007/s004390000390

Cheadle, Jeremy Peter

, Gill, Harinder, Fleming, Nick, Maynard, Julie Helen, Kerr, Alison, Leonard, Helen, Krawczak, Michael, Cooper, David Neil

, Lynch, Sally, Thomas, Nicholas Stuart Tudor, Hughes, Helen, Hulten, Maj, Ravine, David, Sampson, Julian Roy

and Clarke, Angus John

2000. Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location. Human Molecular Genetics 9 (7) , pp. 1119-1129. 10.1093/hmg/9.7.1119

Jones, Alistair C., Austin, Jehannine, Hansen, Nancy, Hoogendoorn, Bastiaan

, Oefner, Peter J., Cheadle, Jeremy Peter

and O'Donovan, Michael Conlon

1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45 (8) , pp. 1133-1140.

Jones, Alistair C., Shyamsundar, Magitha M., Thomas, Meinir W., Maynard, Julie Helen, Idziaszczyk, Shelley, Tomkins, Susan, Sampson, Julian Roy

1999. Comprehensive mutation analysis of TSC1 and TSC2 - and phenotypic correlations in 150 families with tuberous sclerosis. American Journal of Human Genetics 64 (5) , pp. 1305-1315. 10.1086/302381

van Slegtenhorst, M., Nellist, M., Nagelkerken, B., Cheadle, Jeremy Peter

, Snell, Russell, van den Ouweland, Ans, Reuser, Arnold, Sampson, Julian Roy

, Halley, D. and van der Sluijs, Peter 1998. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Human Molecular Genetics 7 (6) , pp. 1053-1057. 10.1093/hmg/7.6.1053

Jones, Alistair C., Daniells, Claire E., Snell, Russell G., Tachataki, Maria, Idziaszczyk, Shelley Alexis, Krawczak, Michael, Sampson, Julian Roy

1997. Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Human Molecular Genetics 6 (12) , pp. 2155-2161. 10.1093/hmg/6.12.2155

Sampson, Julian R.

, Maheshwar, Magitha M., Aspinwall, Richard, Thompson, Peter, Cheadle, Jeremy P

, Ravine, David, Roy, Sushmita, Haan, Eric, Bernstein, Jay and Harris, Peter C. 1997. Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene. American Journal of Human Genetics 61 (4) , pp. 843-851. 10.1086/514888

Maheshwar, Magitha M., Cheadle, Jeremy Peter

, Jones, Alistair C., Myring, Jenny, Fryer, Alan E., Harris, Peter C. and Sampson, Julian Roy

1997. The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis. Human Molecular Genetics 6 (11) , pp. 1991-1996. 10.1093/hmg/6.11.1991

Kobayashi, Toshiyuki, Urakami, Shinji, Cheadle, Jeremy Peter

, Aspinwall, Richard, Harris, Peter, Sampson, Julian Roy

and Hino, Okio 1997. Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog. Mammalian Genome 8 (8) , pp. 554-558. 10.1007/s003359900502

van Slegtenhorst, Marjon, de Hoogt, Ronald, Hermans, Caroline, Nellist, Mark, Janssen, Bart, Verhoef, Senno, Lindhout, Dick, van den Ouwenland, Ans, Halley, Dicky, Young, Janet, Burley, Mariwyn, Jeremiah, Steve, Woodward, Karen, Nahmias, Joseph, Fox, Margaret, Ekong, Rosemary, Osborne, John, Wolfe, Jonathan, Povey, Sue, Snell, Russell G., Cheadle, Jeremy Peter

, Jones, Alistair C., Tachataki, Maria, Ravine, David, Sampson, Julian Roy

, Reeve, Mary Pat, Richardson, Paul, Wilmer, Friederike, Munro, Cheryl, Hawkins, Trevor L., Sepp, Tiina, Ali, Johari B. M., Ward, Susannah, Green, Andrew J., Yates, John R. W., Kwiatkowska, Jolanta, Henske, Elizabeth P., Short, M. Priscilla, Haines, Jonathan H., Jowziak, Sergiusz and Kwiatkowski, David J. 1997. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277 (5327) , pp. 805-808. 10.1126/science.277.5327.805

Aspinwall, Richard, Rothwell, Dominic G., Roldan- Arjona, Teresa, Anselmino, Catherine, Ward, Christopher J., Cheadle, Jeremy Peter