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A review of stability issues associated with vitamins in parenteral nutrition

Ferguson, Thomas Ian, Emery, Sophie, Price-Davies, Rebecca and Cosslett, Allan George 2014. A review of stability issues associated with vitamins in parenteral nutrition. e-SPEN Journal 9 (2) , e49-e53. 10.1016/j.clnme.2014.01.001

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Background & aims There has been a move to increased emphasis on delivering parenteral nutrition to patients at home, which may improve patient care and reduce costs. However, safe provision of home, and indeed any, parenteral nutrition necessitates consideration of the physical and chemical stability of the parenteral nutrition and its components. Methods Medline and Embase were used to search for all English-language publications on vitamin stability. Identified publications were then analysed and summarized in the following review. Results Vitamins are one of the least stable components in PN and there are three main ways in which they have been shown to degrade: photodegradation, oxidation and through storage material interaction. Previous research on vitamins has demonstrated that significant losses can occur in the bag, which could have clinical consequences, particularly for long-term users of parenteral nutrition. These losses are most dramatic for vitamin C, which is rapidly degraded by oxygen, and vitamin A, which is rapidly degraded in the presence of sunlight. Conclusions There are a number of stability issues associated with vitamins in parenteral nutrition and further investigation is needed to assure their stability and compatibility with other parenteral nutrition constituents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Parenteral nutrition; vitamins; stability; degradation.
Publisher: Elsevier
ISSN: 2212-8263
Date of First Compliant Deposit: 30 March 2016
Last Modified: 06 Oct 2021 14:49

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