Wnt signaling and mammary tumorigenesis

Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 and Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2001. Wnt signaling and mammary tumorigenesis. Journal of Mammary Gland Biology and Neoplasia 6 (1) , pp. 37-52.

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Abstract

Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt signaling pathway is a major feature of several human neoplasias and appears to lead to the cytosolic stabilization of a transcriptional co-factor, beta-catenin. This co-activator can then regulate transcription from a number of target genes including the cellular oncogenes cyclin D1 and c-myc. This review will summarize the current state of knowledge of Wnt signal transduction in a range of model systems and will then address the role of Wnts and Wnt signaling in mammary development and cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Uncontrolled Keywords:	APC; Beta-catenin; frizzled; mammary; tumor; Wnt
Publisher:	Springer
ISSN:	1083-3021
Last Modified:	22 Jun 2023 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/61755

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