Stimulus-specific induction of an Egr-I transgene in a rat brain

Slade, J. P., Man, Pui Sin, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan 2002. Stimulus-specific induction of an Egr-I transgene in a rat brain. Neuroreport -Oxford- 13 (5) , pp. 671-674.

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Abstract

Regulated expression of Egr-1 (Zif268/NGFIA) in a variety of brain networks suggests a diversity of roles in neuronal plasticity. Here, we aimed to determine whether an egr-1 transgene would mediate transcriptional responses to different pharmacological and physiological stimuli in the brain of transgenic rats. Constitutive transgene expression was observed in the cortex, CA1 hippocampal area and pituitary, recapitulating expression of egr-1. Transgene induction was stimulus-specific. Metrazole induced widespread expression in the dentate gyrus, CA2 and CA3 areas, amygdala, and ventromedial nucleus. In contrast, induction following a light stimulus was restricted to the hypothalamic suprachiasmatic and periventricular nuclei. Our studies have provided novel insights into the differential regulation of egr-1, and facilitated approaches to the genetic manipulation of Egr-1-regulated neuronal systems.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	27 Oct 2022 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/63055

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