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The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice.
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Rees, Daniel, Beynon, Amy L., Lelos, Mariah J. ORCID: https://orcid.org/0000-0001-7102-055X, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Roberts, Luke D., Phelps, Lyndsey, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578, Morgan, Alwena H., Brown, Rowan M., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Davies, Jefrey S.
2023.
Acyl-ghrelin attenuates neurochemical and motor deficits in the 6-OHDA model of Parkinson’s Disease.
Cellular and Molecular Neurobiology
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Hornsby, Amanda K.E., Buntwal, Luke, Carisi, Maria Carla, Santos, Vanessa V., Johnston, Fionnuala, Roberts, Luke D., Sassi, Martina, Mequinion, Mathieu, Stark, Romana, Reichenbach, Alex, Lockie, Sarah H., Siervo, Mario, Howell, Owain, Morgan, Alwena H., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Andrews, Zane B., Burn, David J. and Davies, Jeffrey S.
2020.
Unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is altered in Parkinson's dementia in humans.
Cell Reports Medicine
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10.1016/j.xcrm.2020.100120
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Tilston, Thomas W, Brown, Richard D, Wateridge, Matthew J, Arms-Williams, Bradley, Walker, Jamie J, Sun, Yuxiang and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2019.
A novel automated system yields reproducible temporal feeding patterns in laboratory rodents.
Journal of Nutrition
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Braxton, Thomas M., Sarpong, Dionne Ea, Dovey, Janine L, Guillou, Anne, Evans, Ba ORCID: https://orcid.org/0000-0003-3664-2569, Castellano, Juan M., Keenan, Bethany E. ORCID: https://orcid.org/0000-0001-7787-2892, Baraghithy, Saja, Evans, Sam L. ORCID: https://orcid.org/0000-0003-3664-2569, Tena-Sempere, Manuel, Mollard, Patrice, Tam, Joseph and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2019.
Thermoneutrality improves skeletal impairment in adult Prader-Willi syndrome mice.
Journal of Endocrinology
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10.1530/JOE-19-0279
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Ratcliff, Michael, Rees, Daniel, McGrady, Scott, Buntwal, Luke, Hornsby, Amanda K. E., Bayliss, Jaqueline, Kent, Brianne A., Bussey, Timothy, Saksida, Lisa, Beynon, Amy L., Howell, Owain W., Morgan, Alwena H., Sun, Yuxiang, Andrews, Zane B., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Davies, Jeffrey S.
2019.
Calorie restriction activates new adult born olfactory-bulb neurones in a ghrelin-dependent manner but acyl-ghrelin does not enhance subventricular zone neurogenesis.
Journal of Neuroendocrinology
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10.1111/jne.12755
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Welden, Justin R., Zhang, Zhaiyi, Duncan, Marilyn J., Falaleeva, Marina, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Stamm, Stefan
2018.
The posterior pituitary expresses the serotonin receptor 2C.
Neuroscience Letters
684
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10.1016/j.neulet.2018.06.051
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Hopkins, Anna L., Nelson, Timothy A. S., Guschina, Irina A., Parsons, Lydia C., Lewis, Charlotte L., Brown, Richard C., Christian, Helen C., Davies, Jeffrey S. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2017.
Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target-cell-induced acylation.
Scientific Reports
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Golding, David M., Rees, Daniel J., Davies, Jennifer R., Relkovic, Dinko, Furby, Hannah V. ORCID: https://orcid.org/0000-0002-7279-1812, Guschina, Irina A., Hopkins, Anna L., Davies, Jeffrey S., Resnick, James L., Isles, Anthony R. ORCID: https://orcid.org/0000-0002-7587-5712 and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2017.
Paradoxical leanness in the imprinting-centre deletion mouse model for Prader–Willi syndrome.
Journal of Endocrinology
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10.1530/JOE-16-0367
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Navein, Alice E., Cooke, Esther J., Davies, Jennifer R., Smith, Terence G., Wells, Lois H. M. ORCID: https://orcid.org/0000-0003-3618-0595, Ohazama, Atsushi, Healy, Christopher, Sharpe, Paul T., Evans, Sam L. ORCID: https://orcid.org/0000-0003-3664-2569, Evans, Bronwen A. J. ORCID: https://orcid.org/0000-0003-3664-2569, Votruba, Marcela ORCID: https://orcid.org/0000-0002-7680-9135 and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2016.
Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.
Human Molecular Genetics
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10.1093/hmg/ddw107
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Hornsby, Amanda K. E., Redhead, Yushi T., Rees, Daniel J., Ratcliff, Michael S. G., Reichenbach, Alex, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Francis, Lewis, Amstalden, Katia, Andrews, Zane B. and Davies, Jeffrey S.
2016.
Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner.
Psychoneuroendocrinology
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Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, James, T. W., James, K., Cox, A., Farr, L., Paisey, Stephen James ORCID: https://orcid.org/0000-0002-2274-3708, Dempster, D. W., Stone, M. D., Griffiths, P. A., Hugtenburg, R. P., Brady, Sir M. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2014.
Preclinical assessment of a new magnetic resonance-based technique for determining bone quality by characterization of trabecular microarchitecture.
Calcified Tissue International
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10.1007/s00223-014-9922-z
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Man, Pui-Sin, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
2014.
Cellular distribution of Egr1 transcription in the male rat pituitary gland.
Journal of Molecular Endocrinology
53
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10.1530/JME-14-0158
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El-Kasti, Muna Mustafa, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
2012.
A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes.
Human Molecular Genetics
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10.1093/hmg/dds389
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Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Davies, Jennifer Rhian, Guschina, Irina, Ball, Daniel, Davies, Jeffrey Stephens, Davies, Vanessa J., Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008 and Votruba, Marcela ORCID: https://orcid.org/0000-0002-7680-9135
2012.
Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome.
Human Molecular Genetics
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10.1093/hmg/dds315
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Glad, C., Kitchen, E., Russ, G., Harris, S., Davies, J., Gevers, E., Gabrielsson, B. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2011.
Reverse feeding suppresses the activity of the GH axis in rats and induces a preobesogenic state.
Endocrinology
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10.1210/en.2010-0713
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Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Bullen, Melanie Jean, Kench, Rebecca Carol, Fox, Rebecca E., Morgan, Liam David ORCID: https://orcid.org/0000-0002-7571-6025, Stevenson, Amy Elizabeth, Gevers, Evelien F., Perry, Mark J. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2011.
The influence of leptin on trabecular architecture and marrow adiposity in GH-deficient rats.
Journal of Endocrinology
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10.1677/JOE-10-0178
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Carter, David Allan, Rough, Kirsty and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2011.
Transcription mapping of embryonic rat brain reveals EGR-1 induction in SOX2+ neural progenitor cells.
Frontiers in Molecular Neuroscience
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10.3389/fnmol.2011.00006
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Davies, Jeffrey Stephens, Kotokorpi, Pia, Eccles, Sinan R., Barnes, Sarah K., Tokarczuk, Pawel Franciszek, Allen, Sophie Katharine, Whitworth, Hilary S., Guschina, Irina, Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Mode, Agneta, Zigman, Jeffrey M. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2009.
Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention.
Molecular Endocrinology
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10.1210/me.2008-0432
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Stevenson, A. E., Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Gevers, E. F., Elford, Carole, McLeod, Robert William J., Perry, M. J., El-Kasti, M. M., Coschigano, K. T., Kopchick, J. J., Evans, Samuel Lewin ORCID: https://orcid.org/0000-0003-3664-2569 and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2009.
Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency?
American Journal of Physiology - Endocrinology and Metabolism
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10.1152/ajpendo.90689.2008
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Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2009.
Ghrelin - Defender of fat.
Progress in Lipid Research
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El-Kasti, Muna Mustafa, Christian, H. C., Huerta-Ocampo, I., Stolbrink, M., Gill, S., Houston, P. A., Davies, J. S., Chilcott, J., Hill, N., Matthews, D. R., Carter, David Allan and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2008.
The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin.
Journal of Neuroendocrinology
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10.1111/j.1365-2826.2008.01650.x
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Davies, J. S., Kotokorpi, P., Lindahl, U., Oscarsson, J., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Mode, A.
2008.
Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats.
Endocrine
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Mansergh, Fiona Catherine, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Elford, Carole, Evans, Samuel Lewin ORCID: https://orcid.org/0000-0003-3664-2569, Evans, Martin John, Perry, Mark J. and Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008
2007.
Osteopenia in Sparc (osteonectin) deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression.
Physiological genomics
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Man, Pui Sin, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
2007.
Egr-1-d2EGFP transgenic rats identify transient populations of neurons and glial cells during postnatal brain development.
Gene Expression Patterns
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Davies, Jeffrey Stephens, Gevers, Evelien F., Stevenson, Amy Elizabeth, Coschigano, Karen T., El-Kasti, Muna Mustafa, Bull, Melanie J., Elford, Carole., Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Kopchick, John J. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2007.
Adiposity profile in the dwarf (dw/dw) rat: an unusually lean model of profound growth hormone deficiency.
American Journal of Physiology - Endocrinology and Metabolism
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10.1152/ajpendo.00417.2006
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Humphries, Ann L., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Baler, Ruben, Klein, David C. and Carter, David Allan
2007.
Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland.
Molecular and Cellular Endocrinology
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10.1016/j.mce.2007.02.003
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Holter, J. L., Davies, J. S., Man, P. S., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
2007.
Transgenic delivery and detection of GFP in neuropeptide neurons.
Neuropeptide Techniques,
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Springer,
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Martini, A. C., Fernández-Fernández, R., Tovar, S., Navarro, V. M., Vigo, E., Vazquez, Marisol, Davies, J. S., Thompson, N. M., Aguilar, E., Pinilla, L., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Dieguez, C and Tena-Sempere, M.
2006.
Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats.
Endocrinology
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10.1210/en.2005-1422
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Davies, Jeffrey S., Thompson, N. M., Christian, H. C., Pinilla, L., Ebling, F. J. P., Tena-Sempere, M. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2006.
Hypothalamic expression of human growth hormone induces post-pubertal hypergonadotrophism in male transgenic growth retarded rats.
Journal of Neuroendocrinology
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Davies, Jeffrey S., Carter, David Allan and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2004.
Photic stimulation inhibits growth hormone secretion in rats: A hypothalamic mechanism for transient entrainment.
Endocrinology
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Davies, Jeffrey Stephens, Holter, J. L., Knight, D., Beaucourt, S. M., Murphy, D., Carter, David A. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2004.
Manipulating sorting signals to generate co-expression of somatostatin and eGFP in the regulated secretory pathway from a monocistronic construct.
Journal of Molecular Endocrinology
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10.1677/jme.1.01578
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Evans, Bronwen A. J. ORCID: https://orcid.org/0000-0002-3082-1008, Warner, Justin T., Elford, Carole, Evans, Samuel Lewin ORCID: https://orcid.org/0000-0003-3664-2569, Laib, L., Bains, R. K., Gregory, John Welbourn ORCID: https://orcid.org/0000-0001-5189-3812 and Wells, Tim ORCID: https://orcid.org/0000-0003-3618-0595
2003.
Morphological determinants of femoral strength in growth hormone-deficient transgenic growth-retarded (Tgr) rats.
Journal of Bone and Mineral Research
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10.1359/jbmr.2003.18.7.1308
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Thompson, Nichola M., Davies, Jeffrey Stephens, Mode, Agneta, Houston, Pamela A. and Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595
2003.
Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats.
Endocrinology
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10.1210/en.2003-0423
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Slade, J. P., Man, Pui Sin, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
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Stimulus-specific induction of an Egr-I transgene in a rat brain.
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Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Houston, P. A.
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Skeletal growth acceleration with growth hormone secretagogues in transgenic growth retarded rats: pattern-dependent effects and mechanisms of desensitization.
Journal of Neuroendocrinology
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Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Carter, David Allan
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Genetic engineering of neural function in transgenic rodents: towards a comprehensive strategy?
Journal of Neuroscience Methods
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10.1016/S0165-0270(01)00391-0
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Smith, Martyn, Burke, Zoe, Humphries, Ann, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Klein, David, Carter, David Allan and Baler, Ruben
2001.
Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2.
Molecular and Cellular Biology
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10.1128/MCB.21.11.3704-3713.2001
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Warner, Justin T., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Elford, Carole, Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008, Evans, Samuel Lewin ORCID: https://orcid.org/0000-0003-3664-2569 and Gregory, John Welbourn ORCID: https://orcid.org/0000-0001-5189-3812
2000.
Undermineralisation and reduced bone strength in growth hormone (GH) deficient transgenic (Tgr) rats.
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