Stem cells and breast cancer: A field in transit

Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 and Ashworth, Alan 2003. Stem cells and breast cancer: A field in transit. Nature Reviews Cancer 3 , pp. 832-844. 10.1038/nrc1212

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Abstract

Evidence that supports the existence of a tumour stem cell for breast cancer has given fresh impetus to the search for an adult mammary epithelial stem cell in the normal breast. Such a cell might be responsible for routine tissue renewal and the massive expansion in epithelial tissue that the breast undergoes during pregnancy, and might be the cell of origin of most, if not all, breast tumours. So, what evidence is there that an adult mammary epithelial stem cell exists, what is its possible identity and what opportunities might the identification of such a cell present for the development of novel therapeutic and prophylactic strategies for treating breast cancer?

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Nature Publishing Group
ISSN:	1474-175X
Last Modified:	27 Oct 2022 09:09
URI:	https://orca.cardiff.ac.uk/id/eprint/64556

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