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Integrins and signal transduction

Cabodi, Sara, Di Stefano, Paola, Leal, Maria del Pilar Camacho, Tinnirello, Agata, Bisaro, Brigitte, Morello, Virginia, Damiano, Laura, Aramu, Simona, Repetto, Daniele, Tornillo, Giusy and Defilippi, Paola 2010. Integrins and signal transduction. In: Becchetti, Andrea and Arcangeli, Annarosa eds. Integrins and ion channels: Molecular complexes and signaling, Vol. 674. New York, NY: Landes Bioscience and Springer Science, pp. 43-54.

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Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Landes Bioscience and Springer Science
ISBN: 9781441960658
Last Modified: 04 Jun 2017 06:55

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