Pepper, C., Buggins, A. G.S., Jones, C. H., Walsby, E. J.  ORCID: https://orcid.org/0000-0001-8523-5017, Forconi, F., Pratt, G., Devereux, S., Stevenson, F. and Fegan, C. ORCID: https://orcid.org/0000-0001-9685-0621
2015.
Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition.
Leukemia
29
, pp. 744-747.
10.1038/leu.2014.308
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Official URL: http://dx.doi.org/10.1038/leu.2014.308
Abstract
The majority of chronic lymphocytic leukemia (CLL) patients are diagnosed with early-stage disease but the currently used prognostic tools appear to be less informative in this group of patients.1 This is especially problematic for patients with mutated immunoglobulin genes (M-CLL) as they have a more diverse clinical course when compared with patients with unmutated immunoglobulin genes (U-CLL).1, 2, 3, 4 Given the emergence of promising targeted, less toxic, therapeutics in CLL,5, 6 there is an increased need to identify patients who might benefit from early treatment with these new agents.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Additional Information: | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Publisher: | Springer Nature |
| ISSN: | 0887-6924 |
| Funders: | Leukaemia & Lymphoma Research, Leukaemia Research Appeal for Wales, NISCHR, Global CLL Research Foundation |
| Date of First Compliant Deposit: | 30 March 2016 |
| Date of Acceptance: | 20 October 2014 |
| Last Modified: | 05 Aug 2023 17:35 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/67297 |
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