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Cas proteins: dodgy scaffolding in breast cancer

Tornillo, Giusy, Defilippi, Paola and Cabodi, Sara 2014. Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Research 16 (5) , 443. 10.1186/s13058-014-0443-5

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The members of the Cas protein family (p130Cas/ BCAR1, Nedd9/HEF1, EFS and CASS4) are scaffold proteins required for the assembly of signal transduction complexes in response to several stimuli, such as growth factors, hormones and extracellular matrix components. Given their ability to integrate and coordinate multiple signalling events, Cas proteins have emerged as crucial players in the control of mammary cell proliferation, survival and differentiation. More importantly, it has been found that alterations of their expression levels result in aberrant signalling cascades, which promote initiation and progression of breast cancer. Based on the increasing data from in vitro, mouse model and clinical studies, in this review we will focus on two Cas proteins, p130Cas/BCAR1 and Nedd9, and their coupled signalling pathways, to examine their role in mammary cell transformation and in the acquirement of invasiveness and drug resistance of breast cancer cells.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: BioMed Central
ISSN: 1465-5411
Date of First Compliant Deposit: 20 February 2019
Last Modified: 20 Feb 2019 15:45

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