Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J., Kähler, A., Akterin, S., Bergen, S., Collins, A., Crowley, J., Fromer, M., Kim, Y., Lee, S., Magnusson, P., Sanchez, N., Stahl, E., Williams, S., Wray, N., Xia, K., Bettella, F., Borglum, A., Bulik-Sullivan, B., Cormican, P., Craddock, Nicholas John ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Abstract
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-Analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI) |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Nature Publishing Group |
ISSN: | 1061-4036 |
Date of Acceptance: | 1 August 2013 |
Last Modified: | 16 Nov 2022 07:31 |
URI: | https://orca.cardiff.ac.uk/id/eprint/75884 |
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