Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J., Kähler, A., Akterin, S., Bergen, S., Collins, A., Crowley, J., Fromer, M., Kim, Y., Lee, S., Magnusson, P., Sanchez, N., Stahl, E., Williams, S., Wray, N., Xia, K., Bettella, F., Borglum, A., Bulik-Sullivan, B., Cormican, P., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, de Leeuw, C., Durmishi, N., Gill, M., Golimbet, V., Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Hougaard, D., Kendler, K., Lin, K., Morris, D., Mors, O., Mortensen, P., Neale, B., O'Neill, F., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Milovancevic, M., Posthuma, D., Powell, J., Richards, Alexander, Riley, B., Ruderfer, D., Rujescu, D., Sigurdsson, E., Silagadze, T., Smit, A., Stefansson, H., Steinberg, S., Suvisaari, J., Tosato, S., Verhage, M., Walters, James Tynan Rhys ORCID: https://orcid.org/0000-0002-6980-4053, Levinson, D., Gejman, P., Kendler, K., Laurent, C., Mowry, B., O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Pulver, A., Riley, B., Schwab, S., Wildenauer, D., Dudbridge, F., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Shi, J., Albus, M., Alexander, M., Campion, D., Cohen, D., Dikeos, D., Duan, J., Eichhammer, P., Godard, S., Hansen, M., Lerer, F., Liang, K., Maier, W., Mallet, J., Nertney, D., Nestadt, G., Norton, N., O'Neill, F., Papadimitriou, G., Ribble, R., Sanders, A., Silverman, J., Walsh, D., Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Wormley, B., Arranz, M., Bakker, S., Bender, S., Bramon, E., Collier, D., Crespo-Facorro, B., Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009, Iyegbe, C., Jablensky, A., Kahn, R., Kalaydjieva, L., Lawrie, S., Lewis, C., Lin, K., Linszen, D., Mata, I., McIntosh, A., Murray, R., Ophoff, R., Powell, John, Rujescu, D., Van Os, J., Walshe, M., Weisbrod, M., Wiersma, D., Donnelly, P., Barroso, I., Blackwell, J., Bramon, E., Brown, M., Casas, J., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H., Mathew, C., Palmer, C., Plomin, R., Rautanen, A., Sawcer, S., Trembath, R., Viswanathan, A., Wood, N., Spencer, C., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Su, Z., Vukcevic, D., Donnelly, P., Langford, C., Hunt, S., Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Gwilliam, R., Blackburn, H., Bumpstead, S., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O., Liddle, J., Potter, S., Ravindrarajah, R., Ricketts, M., Tashakkori-Ghanbaria, A., Waller, M., Weston, P., Widaa, S., Whittaker, P., Barroso, I., Deloukas, P., Mathew, C., Blackwell, J., Brown, M., Corvin, Aiden P, McCarthy, Mark I, Spencer, Chris C A, Bramon, Elvira, Corvin, Aiden P, O'Donovan, Michael C, Stefansson, Kari, Scolnick, Edward, Purcell, Shaun, McCarroll, Steven A, Sklar, Pamela, Hultman, Christina M and Sullivan, Patrick F 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45 (10) , pp. 1150-1159. 10.1038/ng.2742

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Abstract

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-Analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Date of Acceptance:	1 August 2013
Last Modified:	16 Nov 2022 07:31
URI:	https://orca.cardiff.ac.uk/id/eprint/75884

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