CD1d-lipid antigen recognition by the γδTCR

Uldrich, A., Le Nours, J., Pellicci, D., Gherardin, N., McPherson, K., Lim, R., Patel, O., Beddoe, T., Gras, S., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Godfrey, D. 2013. CD1d-lipid antigen recognition by the γδTCR. Nature Immunology 14 (11) , pp. 1137-1145. 10.1038/ni.2713

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Abstract

The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for γδ TCRs. We describe a population of human V δ 1 + γδ T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a γδ TCR binds CD1d-α- galactosylceramide (α-GalCer). The γδ TCR docked orthogonally, over the A′ pocket of CD1d, in which the V δ 1-chain, and in particular the germ line-encoded CDR1δ loop, dominated interactions with CD1d. The TCR γ-chain sat peripherally to the interface, with the CDR3γ loop representing the principal determinant for α-GalCer specificity. Accordingly, we provide insight into how a γδ TCR binds specifically to a lipid-loaded antigen-presenting molecule.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Amino Acid Sequence; Antigens, CD1d; Binding Sites; Databases, Protein; Galactosylceramides; Humans; Molecular Docking Simulation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets
Publisher:	Nature Publishing Group
ISSN:	1529-2908
Date of Acceptance:	19 August 2013
Last Modified:	28 Oct 2022 09:52
URI:	https://orca.cardiff.ac.uk/id/eprint/75958

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