Lipoprotein lipase, a key role in atherosclerosis?

Mead, James R., Cryer, Anthony and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 1999. Lipoprotein lipase, a key role in atherosclerosis? FEBS Letters 462 (1-2) , pp. 1-6. 10.1016/S0014-5793(99)01495-7

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Abstract

Lipoprotein lipase (LPL) plays a central role in lipid metabolism and transport by catalysing the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the adipose tissue and muscles in the provision of non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation is well established. However, recent studies on LPL expressed by cells of the vascular wall, particularly macrophages, have identified additional actions of the enzyme that contribute to the promotion of foam cell formation and atherosclerosis. This review deals with the role of LPL in atherosclerosis, and its regulation by mediators that are known to be present in the lesion.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0014-5793
Last Modified:	28 Oct 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/76952

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