PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Kashir, Junaid, Nomikos, Michail, Swann, Karl ORCID: https://orcid.org/0000-0002-4355-1449 and Lai, Francis ORCID: https://orcid.org/0000-0003-2852-8547 2015. PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. Molecular Human Reproduction 21 (5) , pp. 383-388. 10.1093/molehr/gav009

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Abstract

In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing sperm. The identity of this ‘sperm factor’ thus holds much significance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheath WW domain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Oxford University Press
ISSN:	1360-9947
Date of Acceptance:	23 February 2015
Last Modified:	16 Dec 2023 15:40
URI:	https://orca.cardiff.ac.uk/id/eprint/78532

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