Kashir, Junaid, Nomikos, Michail, Swann, Karl  ORCID: https://orcid.org/0000-0002-4355-1449 and Lai, Francis ORCID: https://orcid.org/0000-0003-2852-8547
2015.
PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis.
Molecular Human Reproduction
21
(5)
, pp. 383-388.
10.1093/molehr/gav009
|
Abstract
In mammals, egg activation is initiated by multiple cytosolic Ca2+ transients (Ca2+ oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing sperm. The identity of this ‘sperm factor’ thus holds much significance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheath WW domain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Oxford University Press |
| ISSN: | 1360-9947 |
| Date of Acceptance: | 23 February 2015 |
| Last Modified: | 16 Dec 2023 15:40 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/78532 |
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