Epidemiology and outcome of community-acquired acute kidney injury

Talabani, Bnar, Zouwail, Soha, Pyart, Rhodri, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Riley, Stephen and Phillips, Aled ORCID: https://orcid.org/0000-0001-9744-7113 2014. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology 19 (5) , pp. 282-287. 10.1111/nep.12221

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Abstract

Aims: Very little data exist regarding community-acquired acute renal injury (CA-AKI). We have identified and characterized a patient cohort with CA-AKI, and documented its impact on renal function and patient mortality. Methods: Using the database of the Medical Biochemistry Department of the Cardiff and Vale University Health Board we identified all patients with CA-AKI over a 1 month period in 2009. Follow-up biochemical and clinical data were used to determine short-term (3 months) and long-term (3 years) outcomes. Comparisons were made to a random and an age/sex matched group. Results: Patients with CA-AKI were older than a non-AKI cohort (70.3 vs 57.1 years; P < 0.0001), with a 61% male predominance. 38% had pre-existing chronic kidney disease (CKD) compared with 25% in the age- and sex-matched non-CA-AKI cohort (P = 0.007). 54% of CA-AKI were admitted for inpatient care. Admission was associated with a higher incidence of complete recovery of renal function. Mortality at 3 months was 16.5%, and was related to the severity of AKI. Over the 3 years of follow-up 71% of patients with CA-AKI developed progressive CKD which was more likely following incomplete/no recovery of renal function and in the context of pre-existing CKD. Three year mortality was 45%, which was higher than that of the age/sex matched control cohort (15.7%; P < 0.0001), but was not related to the development of progressive CKD. Conclusions: CA-AKI carries significant implications in terms of both development of progressive renal disease and high long-term patient mortality.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	1320-5358
Date of Acceptance:	17 February 2014
Last Modified:	16 Dec 2023 15:40
URI:	https://orca.cardiff.ac.uk/id/eprint/78543

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