IL-6 as a keystone cytokine in health and disease

Hunter, Christopher A. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2015. IL-6 as a keystone cytokine in health and disease. Nature Immunology 16 (5) , pp. 448-457. 10.1038/ni.3153

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Abstract

Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not of the immune system and often displays hormone-like characteristics that affect homeostatic processes. IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. However, the signaling cassette that controls the activity of IL-6 is complicated, and distinct intervention strategies can inhibit this pathway. Clinical experience with antagonists of IL-6 has raised new questions about how and when to block this cytokine to improve disease outcome and patient wellbeing. Here we discuss the effect of IL-6 on innate and adaptive immunity and the possible advantages of various antagonists of IL-6 and consider how the immunobiology of IL-6 may inform clinical decisions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General)
Publisher:	Nature Publishing Group
ISSN:	1529-2908
Funders:	Arthritis Research UK
Date of Acceptance:	19 March 2015
Last Modified:	28 Oct 2022 10:32
URI:	https://orca.cardiff.ac.uk/id/eprint/78713

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