Silent substitution S-cone electroretinogram in subjects with diabetes mellitus

Mortlock, Katharine Eirlys ORCID: https://orcid.org/0000-0003-4745-7297, Chiti, Zohreh, Drasdo, Neville, Owens, David Raymond and North, Rachel Valerie ORCID: https://orcid.org/0000-0002-6657-5099 2005. Silent substitution S-cone electroretinogram in subjects with diabetes mellitus. Ophthalmic and physiological optics 25 (5) , pp. 392-399. 10.1111/j.1475-1313.2005.00299.x

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Abstract

A defect in the blue sensitive mechanism has been reported in certain ocular and systemic diseases. For example, tritanopic colour vision defects and changes to the S-cone electroretinogram (ERG) have been demonstrated in glaucoma and diabetes mellitus. Electrophysiological methods of eliciting the S-cone ERG, however, often result in considerable L- and M-cone intrusion. We report the findings of a study employing the silent substitution S-cone ERG technique, which is thought to represent an almost pure S-cone signal, and the L'Anthony desaturated D15 colour vision test in subjects with Type 1 or 2 diabetes mellitus with no or minimal background retinopathy. The results of this study show a significantly increased S-cone ERG b-wave implicit time and significantly worse colour vision in those with background retinopathy compared with those with no diabetic retinopathy. This suggests that S-cone pathway dysfunction may be responsible for the deterioration in colour vision found in diabetes mellitus.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Optometry and Vision Sciences
ISSN:	02755408
Last Modified:	17 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/805

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