Mortlock, Katharine Eirlys  ORCID: https://orcid.org/0000-0003-4745-7297, Chiti, Zohreh, Drasdo, Neville, Owens, David Raymond and North, Rachel Valerie ORCID: https://orcid.org/0000-0002-6657-5099
2005.
Silent substitution S-cone electroretinogram in subjects with diabetes mellitus.
Ophthalmic and physiological optics
25
(5)
, pp. 392-399.
10.1111/j.1475-1313.2005.00299.x
|
Abstract
A defect in the blue sensitive mechanism has been reported in certain ocular and systemic diseases. For example, tritanopic colour vision defects and changes to the S-cone electroretinogram (ERG) have been demonstrated in glaucoma and diabetes mellitus. Electrophysiological methods of eliciting the S-cone ERG, however, often result in considerable L- and M-cone intrusion. We report the findings of a study employing the silent substitution S-cone ERG technique, which is thought to represent an almost pure S-cone signal, and the L'Anthony desaturated D15 colour vision test in subjects with Type 1 or 2 diabetes mellitus with no or minimal background retinopathy. The results of this study show a significantly increased S-cone ERG b-wave implicit time and significantly worse colour vision in those with background retinopathy compared with those with no diabetic retinopathy. This suggests that S-cone pathway dysfunction may be responsible for the deterioration in colour vision found in diabetes mellitus.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Schools > Optometry and Vision Sciences |
| ISSN: | 02755408 |
| Last Modified: | 17 Oct 2022 08:41 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/805 |
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