Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

Li, Jun, Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409, Owen, Sioned, Weeks, Hoi, Zhang, Zhongtao and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2015. Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). International Journal of Molecular Medicine 36 (6) , pp. 1451-1463. 10.3892/ijmm.2015.2390

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Abstract

The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Spandidos Publications
ISSN:	1107-3756
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	7 October 2015
Last Modified:	07 May 2023 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/81026

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