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Autosome search for schizophrenia susceptibility genes in multiply affected families

Rees, M. I., Fenton, I., Williams, Nigel Melville, Holmans, Peter Alan, Norton, N., Cardno, A., Asherson, P., Spurlock, G., Vallada, H., Dawson, E., Li, M. W., Collier, D. A., Powell, J. F., Nanko, S., Gill, M., McGuffin, P. and Owen, Michael John 1999. Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry 4 (4) , pp. 353-359. 10.1038/

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We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3. 6. Nevertheless three regions were suggestive of linkage.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 20 Apr 2020 13:18

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