Rees, M. I., Fenton, I., Williams, Nigel Melville  ORCID: https://orcid.org/0000-0003-1177-6931, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Norton, N., Cardno, A., Asherson, P., Spurlock, G., Vallada, H., Dawson, E., Li, M. W., Collier, D. A., Powell, J. F., Nanko, S., Gill, M., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862
1999.
Autosome search for schizophrenia susceptibility genes in multiply affected families.
Molecular Psychiatry
4
(4)
, pp. 353-359.
10.1038/sj.mp.4000521
|
Abstract
We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3. 6. Nevertheless three regions were suggestive of linkage.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Publisher: | Nature Publishing Group |
| ISSN: | 1359-4184 |
| Last Modified: | 17 Nov 2022 11:57 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/81399 |
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