Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Plant, Darren, Gibbons, Laura J, Wilson, Anthony G, Bax, Deborah E, Morgan, Ann W, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Worthington, Jane, Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Fraser, Christine, Green, Elaine, Grozeva, Detelina, Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Nikolov, Ivan, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40 (10) , pp. 1156-1159. 10.1038/ng.218

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Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Nick Craddock, Christine Fraser, Elaine Green, Detelina Grozeva, Marian Hamshere, Peter Holmans, Ian Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael O'Donovan and Michael Owen are collaborators on this article
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Last Modified:	17 Nov 2022 12:28
URI:	https://orca.cardiff.ac.uk/id/eprint/81967

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