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Rheumatoid arthritis association at 6q23

Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David, Worthington, Jane, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian Lindsay, Holmans, Peter Alan, Jones, Ian Richard, Kirov, George, Escott-Price, Valentina, Nikolov, Ivan, O'Donovan, Michael Conlon, Owen, Michael John and Craddock, Nicholas John 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39 (12) , pp. 1431-1433. 10.1038/ng.2007.32

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The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: Christine Fraser, Elaine Green, Detelina Grozeva, Marian Hamshere, Peter Holmans, Ian Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael O'Donovan, Michael Owen and Nick Craddock are collaborators on this article.
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 15 Jul 2021 01:23

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