Magnetically controllable polymer nanotubes from a cyclized crosslinker for site-specific delivery of doxorubicin

Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604, Leupelt, Daniel, Zheng, Yu, Thomas, Laurent S. V., Werner, Carsten, Steinhart, Martin and Wang, Wenxin 2015. Magnetically controllable polymer nanotubes from a cyclized crosslinker for site-specific delivery of doxorubicin. Scientific Reports 5 , 17478. 10.1038/srep17478

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Abstract

Externally controlled site specific drug delivery could potentially provide a means of reducing drug related side effects whilst maintaining, or perhaps increasing therapeutic efficiency. The aim of this work was to develop a nanoscale drug carrier, which could be loaded with an anti-cancer drug and be directed by an external magnetic field. Using a single, commercially available monomer and a simple one-pot reaction process, a polymer was synthesized and crosslinked within the pores of an anodized aluminum oxide template. These polymer nanotubes (PNT) could be functionalized with iron oxide nanoparticles for magnetic manipulation, without affecting the large internal pore, or inherent low toxicity. Using an external magnetic field the nanotubes could be regionally concentrated, leaving areas devoid of nanotubes. Lastly, doxorubicin could be loaded to the PNTs, causing increased toxicity towards neuroblastoma cells, rendering a platform technology now ready for adaptation with different nanoparticles, degradable pre-polymers, and various therapeutics.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Biosciences Psychology
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General)
Additional Information:	This work is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	29 October 2015
Last Modified:	05 May 2023 11:04
URI:	https://orca.cardiff.ac.uk/id/eprint/83650

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