Decoding advances in psychiatric genetics: a focus on neural circuits in rodent models

Heckenast, Julia R., Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124 and Jones, Matthew W. 2015. Decoding advances in psychiatric genetics: a focus on neural circuits in rodent models. Advances in Genetics 92 , pp. 75-106. 10.1016/bs.adgen.2015.09.001

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Abstract

Appropriately powered genome-wide association studies combined with deep-sequencing technologies offer the prospect of real progress in revealing the complex biological underpinnings of schizophrenia and other psychiatric disorders. Meanwhile, recent developments in genome engineering, including CRISPR, constitute better tools to move forward with investigating these genetic leads. This review aims to assess how these advances can inform the development of animal models for psychiatric disease, with a focus on schizophrenia and in vivo electrophysiological circuit-level measures with high potential as disease biomarkers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Publisher:	Elsevier
ISSN:	0065-2660
Last Modified:	31 Oct 2022 10:33
URI:	https://orca.cardiff.ac.uk/id/eprint/85299

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