Opposite effects of extracellular sodium removal on the uptake of tryptophan into rat cortical slices and synaptosomes

Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124 and Collard, Keith J. 1984. Opposite effects of extracellular sodium removal on the uptake of tryptophan into rat cortical slices and synaptosomes. Journal of Neuroscience 43 (1) , pp. 274-275. 10.1111/j.1471-4159.1984.tb06708.x

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Abstract

Abstract: The removal of extracellular sodium decreased L-tryptophan (L-TRP) uptake into brain slices but in-creased uptake into synaptosomes. The uptake of 5-hy-droxytryptamine (5-HT) was inhibited in both preparations under these conditions. It is suggested that the dif-ferent effects on L-TRP uptake may be due to differencesin cellular composition between the two preparationsrather than to any differences in sample handling.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Uptake;Synaptosomes;Slices;Tryptophan;5-Hydroxytryptamine
Publisher:	Society for Neuroscience
ISSN:	0022-3042
Last Modified:	31 Oct 2022 10:36
URI:	https://orca.cardiff.ac.uk/id/eprint/85463

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